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Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2018

Summary of Significant Accounting Policies [Abstract]

Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis



	September 30, 2018												December 31, 2017
(in thousands)	Level 1			Level 2			Level 3			Total			Level 1			Level 2			Level 3			Total
Assets
Cash and cash equivalents:
Cash and money market funds	$	27,386		$	—		$	—		$	27,386		$	14,858		$	—		$	—		$	14,858
Commercial paper		—			10,677			—			10,677			—			1,649			—			1,649
Total cash and cash equivalents		27,386			10,677			—			38,063			14,858			1,649			—			16,507
Investments:
Commercial paper		—			51,633			—			51,633			—			20,394			—			20,394
Corporate debt securities		—			9,068			—			9,068			—			9,034			—			9,034
US government & agency securities		—			16,983			—			16,983			—			16,937			—			16,937
Total investments		—			77,684			—			77,684			—			46,365			—			46,365
Long-term restricted cash:
Cash		4,500			—			—			4,500			4,500			—			—			4,500
Total assets measured at fair value	$	31,886		$	88,361		$	—		$	120,247		$	19,358		$	48,014		$	—		$	67,372

Liabilities
Financing derivative	$	—		$	—		$	28		$	28		$	—		$	—		$	183		$	183
Total liabilities measured at fair value	$	—		$	—		$	28		$	28		$	—		$	—		$	183		$	183




Estimated Fair Value and Carrying Value of Notes



	September 30, 2018						December 31, 2017
	Fair Value			Carrying Value			Fair Value			Carrying Value
Notes payable	$	15,973		$	14,384		$	15,664		$	13,635



Anti-dilutive Shares Excluded from Computation of Diluted Net Loss per Share



		Nine Months Ended September 30,
(in thousands)		2018		2017
Options to purchase common stock		27,397		25,133
RSUs with time-based vesting		349		—
RSUs with performance-based vesting		634		—



Schedule of Cumulative Effect on Consolidated Balance Sheet for Adoption of ASC 606


Balance Sheet	Balance at December 31, 2017			Adjustments Due to ASC 606			Balance at January 1, 2018
Assets
Prepaid expenses and other current assets	$	2,249		$	189		$	2,438
Liabilities and Stockholders' Equity
Accumulated deficit		(879,733)			189			(879,544)



Schedule of Impact of Revenue Standards Adoption on Financial Statements






	Three Months Ended September 30, 2018									Nine Months Ended September 30, 2018
Statement of Operations and Comprehensive Loss	As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)			As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)
Operating Expense:
Sales, general and administrative	$	13,506		$	13,518		$	(12)		$	43,383		$	43,430		$	(47)










	As of September 30, 2018
Balance Sheet	As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)
Assets
Prepaid expenses and other current assets	$	2,028		$	1,792		$	236
Liabilities and Stockholders' Equity
Accumulated deficit	$	(951,307)		$	(951,071)		$	236








	Nine Months Ended September 30, 2018
Statement of Cash Flows	As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)
Cash Flows from Operating Activities
Net loss	$	(71,763)		$	(71,810)		$	47
Adjustments to reconcile net loss to net cash used in operating activities
Prepaid expenses and other current assets	$	537		$	490		$	47



Summary of Revenue by Category










	Three Months Ended September 30,						Nine Months Ended September 30,
(in thousands)	2018			2017 (1)			2018			2017 (1)
Instrument revenue	$	6,296		$	9,716		$	21,965		$	29,468
Consumable revenue		8,854			10,627			27,952			28,717
Product revenue		15,150			20,343			49,917			58,185
Service and other revenue		3,010			3,202			9,183			10,348
Total revenue	$	18,160		$	23,545		$	59,100		$	68,533




(1) As noted above, prior period amounts have not been adjusted under the modified retrospective method.

Schedule of Revenue by Geographic Location






	Three Months Ended September 30,						Nine Months Ended September 30,
	2018			2017 (1)			2018			2017 (1)
North America	$	8,960		$	9,115		$	25,974		$	30,127
Europe (including the Middle East and Africa)		2,914			3,197			10,614			10,430
Asia Pacific		6,286			11,233			22,512			27,976
Total	$	18,160		$	23,545		$	59,100		$	68,533









(1) As noted above, prior period amounts have not been adjusted under the modified retrospective method.

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