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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Summary of Significant Accounting Policies [Abstract] |
Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis |
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﻿ | December 31, 2018 |  | December 31, 2017 |
﻿(in thousands) | Level 1 |  | Level 2 |  | Level 3 |  | Total |  | Level 1 |  | Level 2 |  | Level 3 |  | Total |
﻿Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
﻿Cash and cash equivalents: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
﻿Cash and money market funds | $ | 18,844 |  | $ | — |  | $ | — |  | $ | 18,844 |  | $ | 14,858 |  | $ | — |  | $ | — |  | $ | 14,858 |
﻿Commercial paper |  | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | 1,649 |  |  | — |  |  | 1,649 |
﻿Total cash and cash equivalents |  | 18,844 |  |  | — |  |  | — |  |  | 18,844 |  |  | 14,858 |  |  | 1,649 |  |  | — |  |  | 16,507 |
﻿Investments: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
﻿Commercial paper |  | — |  |  | 53,469 |  |  | — |  |  | 53,469 |  |  | — |  |  | 20,394 |  |  | — |  |  | 20,394 |
﻿Corporate debt securities |  | — |  |  | 10,214 |  |  | — |  |  | 10,214 |  |  | — |  |  | 9,034 |  |  | — |  |  | 9,034 |
﻿US government & agency securities |  | — |  |  | 19,827 |  |  | — |  |  | 19,827 |  |  | — |  |  | 16,937 |  |  | — |  |  | 16,937 |
﻿Total investments |  | — |  |  | 83,510 |  |  | — |  |  | 83,510 |  |  | — |  |  | 46,365 |  |  | — |  |  | 46,365 |
﻿Long-term restricted cash: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
﻿Cash |  | 4,500 |  |  | — |  |  | — |  |  | 4,500 |  |  | 4,500 |  |  | — |  |  | — |  |  | 4,500 |
﻿Total assets measured at fair value | $ | 23,344 |  | $ | 83,510 |  | $ | — |  | $ | 106,854 |  | $ | 19,358 |  | $ | 48,014 |  | $ | — |  | $ | 67,372 |
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﻿Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
﻿Financing derivative | $ | — |  | $ | — |  | $ | 16 |  | $ | 16 |  | $ | — |  | $ | — |  | $ | 183 |  | $ | 183 |
﻿Total liabilities measured at fair value | $ | — |  | $ | — |  | $ | 16 |  | $ | 16 |  | $ | — |  | $ | — |  | $ | 183 |  | $ | 183 |
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﻿
Changes in Fair Value of Financing Derivative |
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﻿ |  |  |
﻿Financing Derivative |  | Amount
﻿Balance as of December 31, 2016 |  | $ | 356
﻿Loss on change in fair value of Financing Derivative |  |  | 653
﻿Change in fair value due to partial exercise of derivative associated with $4.5 million principal payoff |  |  | (826)
﻿Balance as of December 31, 2017 |  |  | 183
﻿Gain on change in fair value of Financing Derivative |  |  | (167)
﻿Balance as of December 31, 2018 |  | $ | 16
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﻿
Estimated Fair Value and Carrying Value of Notes |
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﻿ | December 31, 2018 |  | December 31, 2017 |
﻿ | Fair Value |  | Carrying Value |  | Fair Value |  | Carrying Value |
﻿Long-term notes payable | $ | 15,915 |  | $ | 14,659 |  | $ | 15,664 |  | $ | 13,635 |
﻿
Anti-dilutive Shares Excluded from Computation of Diluted Net Loss per Share |
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﻿ |  |  |  |  |
﻿ | Years Ended December 31,
﻿(in thousands) | 2018 |  | 2017 |  | 2016
﻿Options to purchase common stock | 25,176 |  | 25,404 |  | 22,501
﻿RSUs with time-based vesting | 371 |  | — |  | —
﻿RSUs with performance-based vesting | 586 |  | — |  | —
﻿
Schedule of Cumulative Effect on Consolidated Balance Sheet for Adoption of ASC 606 |
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﻿Balance Sheet | Balance at December 31, 2017 |  | Adjustments Due to ASC606 |  | Balance at January 1, 2018
﻿Assets |  |  |  |  |  |  |  |
﻿Prepaid expenses and other current assets | $ | 2,249 |  | $ | 189 |  | $ | 2,438
﻿Liabilities and Stockholders' Equity |  |  |  |  |  |  |  |
﻿Accumulated deficit |  | (879,733) |  |  | 189 |  |  | (879,544)
﻿
Schedule of Impact of Revenue Standards Adoption on Financial Statements |
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﻿ | Year Ended December 31, 2018
﻿Statement of Operations and Comprehensive Loss | As Reported |  | Balances Without Adoption of ASC606 |  | Effect of Change Higher/(Lower)
﻿Operating Expense: |  |  |  |  |  |  |  |
﻿Sales, general and administrative | $ | 63,489 |  | $ | 63,547 |  | $ | (58)
﻿ ﻿ ﻿
﻿ |  |  |  |  |  |  |  |
﻿ | As of December 31, 2018
﻿Balance Sheet | As Reported |  | Balances Without Adoption of ASC606 |  | Effect of Change Higher/(Lower)
﻿Assets |  |  |  |  |  |  |  |
﻿Prepaid expenses and other current assets | $ | 2,832 |  | $ | 2,585 |  | $ | 247
﻿Liabilities and Stockholders' Equity |  |  |  |  |  |  |  |
﻿Accumulated deficit | $ | (982,106) |  | $ | (981,859) |  | $ | 247
﻿ ﻿
﻿ |  |  |  |  |  |  |  |
﻿ | Year Ended December 31, 2018
﻿Statement of Cash Flows | As Reported |  | Balances Without Adoption of ASC606 |  | Effect of Change Higher/(Lower)
﻿Cash Flows from Operating Activities |  |  |  |  |  |  |  |
﻿Net loss | $ | (102,562) |  | $ | (102,620) |  | $ | 58
﻿Adjustments to reconcile net loss to net cash used in operating activities |  |  |  |  |  |  |  |
﻿Prepaid expenses and other current assets | $ | (290) |  | $ | (348) |  | $ | 58
﻿
Summary of Revenue by Category | ﻿
﻿ |  |  |  |  |  |  |  |
﻿ | Year Ended December 31,
﻿(in thousands) | 2018 |  | 2017 (1) |  | 2016 (1)
﻿Instrument revenue | $ | 28,492 |  | $ | 38,626 |  | $ | 40,956
﻿Consumable revenue |  | 37,863 |  |  | 41,404 |  |  | 23,653
﻿Product revenue |  | 66,355 |  |  | 80,030 |  |  | 64,609
﻿Service and other revenue |  | 12,271 |  |  | 13,438 |  |  | 13,971
﻿Collaboration revenue |  | — |  |  | — |  |  | 12,134
﻿Total revenue | $ | 78,626 |  | $ | 93,468 |  | $ | 90,714
﻿ ﻿
| (1) |  | As noted above, prior period amounts have not been adjusted under the modified retrospective method of ASC 606.

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- Definition Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19279-110258 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2C -URI http://asc.fasb.org/extlink&oid=99377789&loc=SL7498348-110258 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19190-110258 Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bb) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 + Details
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