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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2018
Income Taxes [Abstract] |
Reconciliation of Federal Income Tax Rate |
﻿ |  |  |  |  |  |  |  |
﻿ |  |  |  |  |  |  |  |
﻿ | Years ended December 31,
﻿ | 2018 |  |  | 2017 |  |  | 2016 |
﻿Statutory tax rate | 21.0 | % |  | 35.0 | % |  | 35.0 | %
﻿State tax rate, net of federal benefit | 3.5 |  |  | 8.6 |  |  | 5.4 |
﻿Stock-based compensation | (1.6) |  |  | (1.9) |  |  | (1.6) |
﻿Tax credits | 2.0 |  |  | 3.6 |  |  | 5.0 |
﻿Remeasurement of deferred taxes due to tax reform | - |  |  | (123.3) |  |  | - |
﻿Other | (0.1) |  |  | 0.3 |  |  | (0.9) |
﻿Change in valuation allowance | (24.8) |  |  | 77.7 |  |  | (42.9) |
﻿Total | - | % |  | - | % |  | - | %
﻿
Reconciliation of Deferred Tax Assets and Liabilities |
﻿ |  |  |  |  |
﻿ |  |  |  |  |
﻿ | December 31,
﻿Deferred tax assets: | 2018 |  | 2017
﻿Net operating loss carryforwards | $ | 212,424 |  | $ | 194,440
﻿Research and development credits |  | 42,635 |  |  | 39,145
﻿Accruals and reserves |  | 19,356 |  |  | 14,480
﻿Deferred rent |  | 3,315 |  |  | 3,360
﻿Total deferred tax assets |  | 277,730 |  |  | 251,425
﻿Less: Valuation allowance |  | (275,540) |  |  | (249,202)
﻿Total deferred tax assets: |  | 2,190 |  |  | 2,223
﻿Fixed assets |  | (2,190) |  |  | (2,223)
﻿Total deferred tax liabilities |  | (2,190) |  |  | (2,223)
﻿Net deferred tax assets | $ | — |  | $ | —
﻿
Reconciliation of Unrecognized Tax Benefit Accounts |
﻿ |  |
﻿ |  |
﻿Decrease in balance related to tax positions taken in prior year | $ | (44)
﻿Increase in balance related to tax positions taken during current year |  | 1,827
﻿Balance as of December 31, 2015 |  | 18,735
﻿Increase in balance related to tax positions taken in prior year |  | 1,942
﻿Decrease in balance related to tax positions taken in current year |  | (3,892)
﻿Balance as of December 31, 2016 |  | 16,785
﻿Decrease in balance related to tax positions taken in prior year |  | —
﻿Increase in balance related to tax positions taken during current year |  | 2,001
﻿Balance as of December 31, 2017 |  | 18,786
﻿Decrease in balance related to tax positions taken in prior year |  | —
﻿Increase in balance related to tax positions taken during current year |  | 1,661
﻿Balance as of December 31, 2018 | $ | 20,447
﻿

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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