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Income Taxes (Reconciliation of Deferred Tax Assets and Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 212,424 | $ 194,440
Research and development credits | 42,635 | 39,145
Accruals and reserves | 19,356 | 14,480
Deferred rent | 3,315 | 3,360
Total deferred tax assets | 277,730 | 251,425
Less: Valuation allowance | (275,540) | (249,202)
Total deferred tax assets: | 2,190 | 2,223
Fixed assets | (2,190) | (2,223)
Total deferred tax liabilities | (2,190) | (2,223)
Net deferred tax assets |  |

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