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Consolidated Statements of Cash Flows $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Cash flows from operating activities |  |  |
Net loss | $ (102,562) | $ (92,189) | $ (74,375)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Depreciation and amortization | 7,215 | 8,442 | 3,875
Amortization of debt discount and financing costs | 1,024 | 1,203 | 1,158
Stock-based compensation | 23,153 | 20,352 | 19,562
Non-cash portion of gain on lease amendments |  |  |
(Gain) loss from derivative | (167) | 653 | (244)
Amortization and accretion for investment premium (discount) | (758) | 47 | 97
Changes in assets and liabilities |  |  |
Accounts receivable | 4,838 | (2,012) | (6,176)
Inventory | 3,623 | (8,442) | (6,151)
Prepaid expenses and other assets | (290) | 7,803 | (202)
Accounts payable | (2,239) | 764 | 3,402
Accrued expenses | 205 | (3,986) | 1,053
Deferred service revenue | 33 | (1,033) | 469
Deferred contractual revenue |  |  | (12,134)
Other liabilities | (505) | 880 | 1,737
Net cash used in operating activities | (66,430) | (67,518) | (67,929)
Cash flows from investing activities |  |  |
Purchase of property and equipment | (1,854) | (10,433) | (8,207)
Proceeds from disposal of property and equipment |  | 41 | 10
Purchase of investments | (122,183) | (86,339) | (95,848)
Sales of investments | 2,442 | 7,111 | 23,285
Maturities of investments | 83,180 | 88,071 | 65,896
Net cash used in investing activities | (38,415) | (1,549) | (14,864)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock from equity plans | 9,652 | 8,914 | 7,729
Notes payable principal payoff |  | (4,500) |
Net cash provided by financing activities | 107,182 | 68,809 | 65,929
Net decrease in cash and cash equivalents and restricted cash | 2,337 | (258) | (16,864)
Cash and cash equivalents and restricted cash at beginning of period | 21,007 | 21,265 | 38,129
Cash and cash equivalents and restricted cash at end of period | 23,344 | 21,007 | 21,265
Cash and cash equivalents at end of period | 18,844 | 16,507 | 16,765
Restricted cash at end of period | 4,500 | 4,500 | 4,500
Supplemental disclosure of cash flow information |  |  |
Interest paid | 1,400 | 1,687 | 1,799
Supplemental disclosure of non-cash investing and financing activities |  |  |
Inventory transferred to property and equipment | 1,871 | 1,267 | 1,282
Property and equipment paid by landlord |  | 12,600 |
Changes in deposits for property and equipment paid in prior period |  | 9,694 |
Property and equipment returned to landlord |  | 1,854 |
At the Market Offering [Member] |  |  |
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock from equity offerings, net of issuance costs |  | 11,865 | $ 58,200
Underwritten Public Equity Offering [Member] |  |  |
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock from equity offerings, net of issuance costs | $ 97,530 | $ 52,530 |

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- Definition Amount of cash inflow from maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3151-108585 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash outflow for a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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- Definition Amount of cash and cash equivalents restricted as to withdrawal or usage. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(2)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(1)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=98513485&loc=SL98516268-108586 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(1)(a)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3044-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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