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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Summary of Significant Accounting Policies [Abstract]

Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis



	December 31, 2018												December 31, 2017
(in thousands)	Level 1			Level 2			Level 3			Total			Level 1			Level 2			Level 3			Total
Assets
Cash and cash equivalents:
Cash and money market funds	$	18,844		$	—		$	—		$	18,844		$	14,858		$	—		$	—		$	14,858
Commercial paper		—			—			—			—			—			1,649			—			1,649
Total cash and cash equivalents		18,844			—			—			18,844			14,858			1,649			—			16,507
Investments:
Commercial paper		—			53,469			—			53,469			—			20,394			—			20,394
Corporate debt securities		—			10,214			—			10,214			—			9,034			—			9,034
US government & agency securities		—			19,827			—			19,827			—			16,937			—			16,937
Total investments		—			83,510			—			83,510			—			46,365			—			46,365
Long-term restricted cash:
Cash		4,500			—			—			4,500			4,500			—			—			4,500
Total assets measured at fair value	$	23,344		$	83,510		$	—		$	106,854		$	19,358		$	48,014		$	—		$	67,372

Liabilities
Financing derivative	$	—		$	—		$	16		$	16		$	—		$	—		$	183		$	183
Total liabilities measured at fair value	$	—		$	—		$	16		$	16		$	—		$	—		$	183		$	183




Changes in Fair Value of Financing Derivative



Financing Derivative		Amount
Balance as of December 31, 2016		$	356
Loss on change in fair value of Financing Derivative			653
Change in fair value due to partial exercise of derivative associated with $4.5 million principal payoff			(826)
Balance as of December 31, 2017			183
Gain on change in fair value of Financing Derivative			(167)
Balance as of December 31, 2018		$	16




Estimated Fair Value and Carrying Value of Notes



	December 31, 2018						December 31, 2017
	Fair Value			Carrying Value			Fair Value			Carrying Value
Long-term notes payable	$	15,915		$	14,659		$	15,664		$	13,635



Anti-dilutive Shares Excluded from Computation of Diluted Net Loss per Share



	Years Ended December 31,
(in thousands)	2018		2017		2016
Options to purchase common stock	25,176		25,404		22,501
RSUs with time-based vesting	371		—		—
RSUs with performance-based vesting	586		—		—



Schedule of Cumulative Effect on Consolidated Balance Sheet for Adoption of ASC 606


Balance Sheet	Balance at December 31, 2017			Adjustments Due to ASC606			Balance at January 1, 2018
Assets
Prepaid expenses and other current assets	$	2,249		$	189		$	2,438
Liabilities and Stockholders' Equity
Accumulated deficit		(879,733)			189			(879,544)



Schedule of Impact of Revenue Standards Adoption on Financial Statements


	Year Ended December 31, 2018
Statement of Operations and Comprehensive Loss	As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)
Operating Expense:
Sales, general and administrative	$	63,489		$	63,547		$	(58)








	As of December 31, 2018
Balance Sheet	As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)
Assets
Prepaid expenses and other current assets	$	2,832		$	2,585		$	247
Liabilities and Stockholders' Equity
Accumulated deficit	$	(982,106)		$	(981,859)		$	247






	Year Ended December 31, 2018
Statement of Cash Flows	As Reported			Balances Without Adoption of ASC606			Effect of Change Higher/(Lower)
Cash Flows from Operating Activities
Net loss	$	(102,562)		$	(102,620)		$	58
Adjustments to reconcile net loss to net cash used in operating activities
Prepaid expenses and other current assets	$	(290)		$	(348)		$	58



Summary of Revenue by Category




	Year Ended December 31,
(in thousands)	2018			2017 (1)			2016 (1)
Instrument revenue	$	28,492		$	38,626		$	40,956
Consumable revenue		37,863			41,404			23,653
Product revenue		66,355			80,030			64,609
Service and other revenue		12,271			13,438			13,971
Collaboration revenue		—			—			12,134
Total revenue	$	78,626		$	93,468		$	90,714





(1) As noted above, prior period amounts have not been adjusted under the modified retrospective method of ASC 606.

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