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Income Taxes (Reconciliation of Deferred Tax Assets and Liabilities) (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Deferred tax assets:
Net operating loss carryforwards	$ 212,424	$ 194,440
Research and development credits	42,635	39,145
Accruals and reserves	19,356	14,480
Deferred rent	3,315	3,360
Total deferred tax assets	277,730	251,425
Less: Valuation allowance	(275,540)	(249,202)
Total deferred tax assets:	2,190	2,223
Fixed assets	(2,190)	(2,223)
Total deferred tax liabilities	(2,190)	(2,223)
Net deferred tax assets

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