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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Taxes [Abstract]

Reconciliation of Federal Income Tax Rate



	Years ended December 31,
	2018			2017			2016
Statutory tax rate	21.0	%		35.0	%		35.0	%
State tax rate, net of federal benefit	3.5			8.6			5.4
Stock-based compensation	(1.6)			(1.9)			(1.6)
Tax credits	2.0			3.6			5.0
Remeasurement of deferred taxes due to tax reform	-			(123.3)			-
Other	(0.1)			0.3			(0.9)
Change in valuation allowance	(24.8)			77.7			(42.9)
Total	-	%		-	%		-	%



Reconciliation of Deferred Tax Assets and Liabilities



	December 31,
Deferred tax assets:	2018			2017
Net operating loss carryforwards	$	212,424		$	194,440
Research and development credits		42,635			39,145
Accruals and reserves		19,356			14,480
Deferred rent		3,315			3,360
Total deferred tax assets		277,730			251,425
Less: Valuation allowance		(275,540)			(249,202)
Total deferred tax assets:		2,190			2,223
Fixed assets		(2,190)			(2,223)
Total deferred tax liabilities		(2,190)			(2,223)
Net deferred tax assets	$	—		$	—



Reconciliation of Unrecognized Tax Benefit Accounts



Decrease in balance related to tax positions taken in prior year	$	(44)
Increase in balance related to tax positions taken during current year		1,827
Balance as of December 31, 2015		18,735
Increase in balance related to tax positions taken in prior year		1,942
Decrease in balance related to tax positions taken in current year		(3,892)
Balance as of December 31, 2016		16,785
Decrease in balance related to tax positions taken in prior year		—
Increase in balance related to tax positions taken during current year		2,001
Balance as of December 31, 2017		18,786
Decrease in balance related to tax positions taken in prior year		—
Increase in balance related to tax positions taken during current year		1,661
Balance as of December 31, 2018	$	20,447



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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of the change in unrecognized tax benefits.

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