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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
At the Market Offering [Member]
Common Stock [Member]
At the Market Offering [Member]
Additional Paid-in Capital [Member]
At the Market Offering [Member]
Underwritten Public Equity Offering [Member]
Common Stock [Member]
Underwritten Public Equity Offering [Member]
Additional Paid-in Capital [Member]
Underwritten Public Equity Offering [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2015             $ 80 $ 786,636 $ (7) $ (713,169) $ 73,540
Balance, shares at Dec. 31, 2015             79,983        
Net loss                   (74,375) (74,375)
Other comprehensive loss                 12   12
Issuance of common stock in conjunction with equity plans             $ 2 7,727     7,729
Issuance of common stock in conjunction with equity plans, shares             2,004        
Issuance of common stock in conjunction with offering, net of issuance costs $ 7 $ 58,193 $ 58,200                
Issuance of common stock in conjunction with offering, net of issuance costs, shares 6,526                    
Issuance of common stock from exercise of warrant             $ 4 (4)      
Issuance of common stock from exercise of warrant, shares             4,164        
Stock-based compensation expense               19,562     19,562
Balance at Dec. 31, 2016             $ 93 872,114 5 (787,544) 84,668
Balance, shares at Dec. 31, 2016             92,677        
Net loss                   (92,189) (92,189)
Other comprehensive loss                 (37)   (37)
Issuance of common stock in conjunction with equity plans             $ 2 8,912     8,914
Issuance of common stock in conjunction with equity plans, shares             2,697        
Issuance of common stock in conjunction with offering, net of issuance costs $ 3 $ 11,862 $ 11,865 $ 18 $ 52,512 $ 52,530          
Issuance of common stock in conjunction with offering, net of issuance costs, shares 3,171   3,200 17,732              
Stock-based compensation expense               20,352     20,352
Balance at Dec. 31, 2017             $ 116 965,752 (32) (879,733) $ 86,103
Balance, shares at Dec. 31, 2017             116,277       116,277
Net loss                   (102,562) $ (102,562)
Other comprehensive loss                 (4)   (4)
ASC606 adoption effect                   189 189
Issuance of common stock in conjunction with equity plans             $ 4 9,648     9,652
Issuance of common stock in conjunction with equity plans, shares             3,357        
Issuance of common stock in conjunction with offering, net of issuance costs       $ 30 $ 97,500 $ 97,530          
Issuance of common stock in conjunction with offering, net of issuance costs, shares       30,610   30,600          
Stock-based compensation expense               23,153     23,153
Balance at Dec. 31, 2018             $ 150 $ 1,096,053 $ (36) $ (982,106) $ 114,061
Balance, shares at Dec. 31, 2018             150,244       150,244