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Income Taxes (Narrative) (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Taxes [Line Items]        
Income before taxes from U.S. operations $ (103,100) $ (92,700) $ (74,000)  
Income before taxes from foreign operations $ 800 $ 1,000 $ 300  
Statutory tax rate 21.00% 35.00% 35.00%  
Net operating loss carryforwards $ 212,400      
Research and development credit carryforward 42,600      
Deferred tax assets 277,730 $ 251,425    
Valuation allowance 275,540 249,202    
Total unrecognized tax benefit 20,447 18,786 $ 16,785 $ 18,735
Accrued interest or penalties 0 $ 0    
Federal [Member]        
Income Taxes [Line Items]        
Net operating loss carryforwards $ 832,000      
Net operating loss carryforward, expiration 2024      
Research and development credit carryforward $ 33,700      
Research and developmen tax credit carryforward, expiration 2024      
State [Member]        
Income Taxes [Line Items]        
Net operating loss carryforwards $ 566,600      
Net operating loss carryforward, expiration 2018      
Research and development credit carryforward $ 34,400