<SEC-DOCUMENT>0001085146-19-000743.txt : 20190214
<SEC-HEADER>0001085146-19-000743.hdr.sgml : 20190214
<ACCEPTANCE-DATETIME>20190214074654
ACCESSION NUMBER:		0001085146-19-000743
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20190214
DATE AS OF CHANGE:		20190214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-85738
		FILM NUMBER:		19600777

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Consonance Capital Management LP
		CENTRAL INDEX KEY:			0001544773
		IRS NUMBER:				260294313
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1370 AVENUE OF THE AMERICAS
		STREET 2:		SUITE 3301
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		212.660-8062

	MAIL ADDRESS:	
		STREET 1:		1370 AVENUE OF THE AMERICAS
		STREET 2:		SUITE 3301
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>pacba3_21419.htm
<DESCRIPTION>CONSONANCE CAPITAL MANAGEMENT LP
<TEXT>

<html>
<head>
    <title>pacba3_21419.htm</title>
</head>
<body>

    <div style="font-family: Georgia,'Times New Roman',Times,serif; font-size: 10pt; width: 8.2in;">
        <div>
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">
                <div style="margin: auto;">UNITED STATES</div>
                <div style="margin: auto;">SECURITIES AND EXCHANGE COMMISSION</div>
                <div style="font-size: 11pt;">Washington, D.C. 20549</div>
                <div style="padding: 1em 0;">SCHEDULE 13G</div>
                <div style="padding: 1em 0; font-size: 11pt;">
                    <div>Under the Securities Exchange Act of 1934</div>

                    <div>(Amendment No. 3)*</div>

                </div>
                <div style="padding: 1em 0;">
                    <div style="text-decoration: underline;">Pacific Biosciences of California, Inc.</div>
                    <div style="font-weight: normal; font-size: 11pt;">(Name of Issuer)</div>
                </div>
                <div style="padding: 1em 0;">
                    <div style="text-decoration: underline;">Common Stock, par value $0.001 per share</div>
                    <div style="font-weight: normal; font-size: 11pt;">(Title of Class of Securities)</div>
                </div>
                <div style="padding: 1em 0;">
                    <div style="text-decoration: underline;">69404D108</div>
                    <div style="font-weight: normal; font-size: 11pt;">(CUSIP Number)</div>
                </div>
                <div style="padding: 1em 0;">
                    <div style="text-decoration: underline;">December 31, 2018</div>
                    <div style="font-weight: normal; font-size: 11pt;">(Date of Event which Requires Filing of this Statement)</div>
                </div>
            </div>
            <div style="padding: 1em 0;">
                Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
            </div>
            <div style="padding: 1em 0; text-align: center;">
                <div style="display: inline-block; text-align: left; margin: 0 auto;">
                    <div>[X] Rule 13d-1(b)</div>
                    <div>[&nbsp;&nbsp;&nbsp;] Rule 13d-1(c)</div>
                    <div>[&nbsp;&nbsp;&nbsp;] Rule 13d-1(d)</div>
                </div>
            </div>
            <div style="padding: 1em 0;">
                * The remainder of this cover page shall be filled out for a reporting person's initial filing on
				this form with respect to the subject class of securities, and for any subsequent amendment
				containing information which would alter the disclosures provided in a prior cover page.
            </div>
            <div style="padding: 1em 0;">
                The information required in the remainder of this cover page shall not be deemed to be "filed"
				for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject
				to the liabilities of that section of the Act but shall be subject	to all other provisions of the
				Act (however, see Instructions).
            </div>
        </div>

                <div style="page-break-before: always; margin-top: 4em;">
                    <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
                    <table border="0" cellpadding="5" style="font-size: 10pt; width: 100%; border-collapse: collapse;">
                        <tr>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 10%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 80%;">&nbsp;</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">1</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="margin-bottom: 1em;">
                                    <div style="font-weight: bold;">NAME OF REPORTING PERSON</div>
                                    <div>Consonance Capital Management LP </div>
                                </div>
                                <div>
                                    <div style="font-weight: bold;">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</div>
                                    <div></div>
                                </div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">2</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                                <div>(a)  [&nbsp;&nbsp;&nbsp;]</div>
                                <div>(b)  [&nbsp;&nbsp;&nbsp;]</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">3</td>
                            <td colspan="3" style="font-weight: bold;">SEC USE ONLY</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">4</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                                <div>Delaware, USA</div>
                            </td>
                        </tr>
                        <tr>
                            <td rowspan="4" colspan="2" style="width: 10%; text-align: center; border: solid 1px; font-weight: bold;">NUMBER OF SHARES BENEFICIALLY OWNED	BY EACH REPORTING PERSON WITH</td>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">5</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE VOTING POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">6</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED VOTING POWER</div>
                                <div>2,392,074</div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">7</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE DISPOSITIVE POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">8</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED DISPOSITIVE POWER</div>
                                <div>2,392,074</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">9</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                                <div>2,392,074</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">10</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
                                [&nbsp;&nbsp;&nbsp;]
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">11</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
                                <div>1.64% Based on 148,901,892 shares of common stock outstanding as of October 31, 2018
as reported in the Issuer&#8217;s Form 10-Q filed with the SEC on November 5, 2018.</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">12</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">TYPE OF REPORTING PERSON</div>
                                <div>IA, PN </div>
                            </td>
                        </tr>
                    </table>
                </div>

                <div style="page-break-before: always; margin-top: 4em;">
                    <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
                    <table border="0" cellpadding="5" style="font-size: 10pt; width: 100%; border-collapse: collapse;">
                        <tr>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 10%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 80%;">&nbsp;</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">1</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="margin-bottom: 1em;">
                                    <div style="font-weight: bold;">NAME OF REPORTING PERSON</div>
                                    <div>Consonance Capital Opportunity Fund Management LP</div>
                                </div>
                                <div>
                                    <div style="font-weight: bold;">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</div>
                                    <div></div>
                                </div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">2</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                                <div>(a)  [&nbsp;&nbsp;&nbsp;]</div>
                                <div>(b)  [&nbsp;&nbsp;&nbsp;]</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">3</td>
                            <td colspan="3" style="font-weight: bold;">SEC USE ONLY</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">4</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                                <div>Delaware, USA</div>
                            </td>
                        </tr>
                        <tr>
                            <td rowspan="4" colspan="2" style="width: 10%; text-align: center; border: solid 1px; font-weight: bold;">NUMBER OF SHARES BENEFICIALLY OWNED	BY EACH REPORTING PERSON WITH</td>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">5</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE VOTING POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">6</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED VOTING POWER</div>
                                <div>63,040</div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">7</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE DISPOSITIVE POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">8</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED DISPOSITIVE POWER</div>
                                <div>63,040</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">9</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                                <div>63,040</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">10</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
                                [&nbsp;&nbsp;&nbsp;]
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">11</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
                                <div>0.04% Based on 148,901,892 shares of common stock outstanding as of October 31, 2018
as reported in the Issuer&#8217;s Form 10-Q filed with the SEC on November 5, 2018.</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">12</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">TYPE OF REPORTING PERSON</div>
                                <div>IA, PN</div>
                            </td>
                        </tr>
                    </table>
                </div>

                <div style="page-break-before: always; margin-top: 4em;">
                    <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
                    <table border="0" cellpadding="5" style="font-size: 10pt; width: 100%; border-collapse: collapse;">
                        <tr>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 10%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 80%;">&nbsp;</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">1</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="margin-bottom: 1em;">
                                    <div style="font-weight: bold;">NAME OF REPORTING PERSON</div>
                                    <div>Mitchell Blutt</div>
                                </div>
                                <div>
                                    <div style="font-weight: bold;">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</div>
                                    <div></div>
                                </div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">2</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                                <div>(a)  [&nbsp;&nbsp;&nbsp;]</div>
                                <div>(b)  [&nbsp;&nbsp;&nbsp;]</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">3</td>
                            <td colspan="3" style="font-weight: bold;">SEC USE ONLY</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">4</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                                <div>USA</div>
                            </td>
                        </tr>
                        <tr>
                            <td rowspan="4" colspan="2" style="width: 10%; text-align: center; border: solid 1px; font-weight: bold;">NUMBER OF SHARES BENEFICIALLY OWNED	BY EACH REPORTING PERSON WITH</td>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">5</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE VOTING POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">6</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED VOTING POWER</div>
                                <div>2,455,114</div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">7</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE DISPOSITIVE POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">8</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED DISPOSITIVE POWER</div>
                                <div>2,455,114</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">9</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                                <div>2,455,114</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">10</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
                                [&nbsp;&nbsp;&nbsp;]
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">11</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
                                <div>1.65% Based on 148,901,892 shares of common stock outstanding as of October 31, 2018
as reported in the Issuer&#8217;s Form 10-Q filed with the SEC on November 5, 2018.</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">12</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">TYPE OF REPORTING PERSON</div>
                                <div>HC, IN</div>
                            </td>
                        </tr>
                    </table>
                </div>

                <div style="page-break-before: always; margin-top: 4em;">
                    <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
                    <table border="0" cellpadding="5" style="font-size: 10pt; width: 100%; border-collapse: collapse;">
                        <tr>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 10%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 5%;">&nbsp;</td>
                            <td style="line-height: 1px; width: 80%;">&nbsp;</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">1</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="margin-bottom: 1em;">
                                    <div style="font-weight: bold;">NAME OF REPORTING PERSON</div>
                                    <div>Consonance Capman GP LLC</div>
                                </div>
                                <div>
                                    <div style="font-weight: bold;">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</div>
                                    <div></div>
                                </div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">2</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                                <div>(a)  [&nbsp;&nbsp;&nbsp;]</div>
                                <div>(b)  [&nbsp;&nbsp;&nbsp;]</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">3</td>
                            <td colspan="3" style="font-weight: bold;">SEC USE ONLY</td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">4</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                                <div>Delaware USA</div>
                            </td>
                        </tr>
                        <tr>
                            <td rowspan="4" colspan="2" style="width: 10%; text-align: center; border: solid 1px; font-weight: bold;">NUMBER OF SHARES BENEFICIALLY OWNED	BY EACH REPORTING PERSON WITH</td>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">5</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE VOTING POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">6</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED VOTING POWER</div>
                                <div>2,455,114</div>
                            </td>
                        </tr>
                        <tr style="border: solid 1px black;">
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">7</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SOLE DISPOSITIVE POWER</div>
                                <div></div>
                            </td>
                        </tr>
                        <tr>
                            <td style="text-align: center; border: solid 1px; vertical-align: top;">8</td>
                            <td style="border: solid 1px black;">
                                <div style="font-weight: bold;">SHARED DISPOSITIVE POWER</div>
                                <div>2,455,114</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">9</td>
                            <td colspan="3" style="border: solid 1px black;">
                                <div style="font-weight: bold;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                                <div>2,455,114</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">10</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
                                [&nbsp;&nbsp;&nbsp;]
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">11</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
                                <div>1.65% Based on 148,901,892 shares of common stock outstanding as of October 31, 2018
as reported in the Issuer&#8217;s Form 10-Q filed with the SEC on November 5, 2018.</div>
                            </td>
                        </tr>
                        <tr>
                            <td style="border: solid 1px; text-align: center; vertical-align: top;">12</td>
                            <td colspan="3" style="border: solid 1px;">
                                <div style="font-weight: bold;">TYPE OF REPORTING PERSON</div>
                                <div>HC, OO</div>
                            </td>
                        </tr>
                    </table>
                </div>

        <div style="page-break-before: always; margin-top: 4em;">
            <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
            <table cellpadding="5" cellspacing="0" border="0" style="font-size: 10pt; width: 100%; margin: 2em auto; border: 0; border-collapse: collapse;">
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 1(a).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>NAME OF ISSUER:</strong>
                        <div style="padding: 1ex 0;">
                            Pacific Biosciences of California, Inc.
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 1(b).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:</strong>
                        <div style="padding: 1ex 0;">
                            1380 Willow Road<br>Menlo Park, CA 94025
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 2(a).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>NAME OF PERSON FILING:</strong>
                        <div style="padding: 1ex 0;">
                            Consonance Capital Management LP <br>Consonance Capital Opportunity Fund Management LP<br>Mitchell Blutt<br>Consonance Capman GP LLC
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 2(b).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:</strong>
                        <div style="padding: 1ex 0;">
                            1370 Avenue of the Americas<br>Floor 33<br>New York, NY 10019
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 2(c).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>CITIZENSHIP:</strong>
                        <div style="padding: 1ex 0;">
                            Delaware, USA<br>Delaware, USA<br>USA<br>Delaware USA
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 2(d).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>TITLE OF CLASS OF SECURITIES:</strong>
                        <div style="padding: 1ex 0;">
                            Common Stock, par value $0.001 per share
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 2(e).</strong></td>
                    <td colspan="2" valign="top">
                        <strong>CUSIP NUMBER:</strong>
                        <div style="padding: 1ex 0;">
                            69404D108
                        </div>
                    </td>
                </tr>
                <tr>
                    <td rowspan="13" valign="top" style="white-space: nowrap;"><strong>ITEM 3.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>IF THIS STATEMENT IS FILED PURSUANT TO SECTION 240.13d-1(b), or 13d-2(b) or (c)	CHECK WHETHER THE PERSON FILING IS A:</strong>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap; width: 11%;">
                        <div style="width: 30px; display: inline-block;">(a)</div>
                        [ ]</td>
                    <td valign="top">Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78c);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(b)</div>
                        [ ]</td>
                    <td valign="top">Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(c)</div>
                        [ ]</td>
                    <td valign="top">Insurance company as defined in Section 3(a)(19) of the Act (15 U.S.C. 78c);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(d)</div>
                        [ ]</td>
                    <td valign="top">Investment company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(e)</div>
                        [X]</td>
                    <td valign="top">An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(f)</div>
                        [ ]</td>
                    <td valign="top">An employee benefit plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(g)</div>
                        [X]</td>
                    <td valign="top">A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(h)</div>
                        [ ]</td>
                    <td valign="top">A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(i)</div>
                        [ ]</td>
                    <td valign="top">A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(j)</div>
                        [ ]</td>
                    <td valign="top">A non-U.S. institution in accordance with 240.13d-1(b)(1)(ii)(J);</td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;">
                        <div style="width: 30px; display: inline-block;">(k)</div>
                        [ ]</td>
                    <td valign="top">Group, in accordance with 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with 240.13d1(b)(1)(ii)(J), please specify the type of institution:
						<div></div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" colspan="2">
						<div style="margin-bottom:1em;"></div>
                    </td>
                </tr>
                <tr>
                    <td rowspan="14" valign="top" style="white-space: nowrap;"><strong>ITEM 4.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>OWNERSHIP</strong>
                    </td>
                </tr>
                <tr>
                    <td colspan="2" valign="top"><strong>(a) Amount beneficially owned:</strong></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top">Consonance Capital Management LP	 2,392,074 <br>Consonance Capital Opportunity Fund Management LP	 63,040 <br>Mitchell Blutt	 2,455,114 <br>Consonance Capman GP LLC	 2,455,114 <br></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top"><strong>(b) Percent of class:</strong></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top">Consonance Capital Management LP	1.61%<br>Consonance Capital Opportunity Fund Management LP	0.04%<br>Mitchell Blutt	1.65%<br>Consonance Capman GP LLC	1.65%<br><br> </td>
                </tr>
                <tr>
                    <td colspan="2" valign="top"><strong>(c) Number of shares as to which the person has:</strong></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;">(i) sole power to vote or to direct the vote:</td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;"></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;">(ii) shared power to vote or to direct the vote:</td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;">Consonance Capital Management LP	 2,392,074 <br>Consonance Capital Opportunity Fund Management LP	 63,040 <br>Mitchell Blutt	 2,455,114 <br>Consonance Capman GP LLC	 2,455,114 <br></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;">(iii) sole power to dispose or direct the disposition of:</td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;"></td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;">(iv) shared power to dispose or to direct the disposition of:</td>
                </tr>
                <tr>
                    <td colspan="2" valign="top" style="padding-left: 28px;">Consonance Capital Management LP	 2,392,074 <br>Consonance Capital Opportunity Fund Management LP	 63,040 <br>Mitchell Blutt	 2,455,114 <br>Consonance Capman GP LLC	 2,455,114 <br></td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 5.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:</strong>
                        <div style="padding: 1ex 0;">
                            If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following
						    [X].
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 6.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:</strong>
                        <div style="padding: 1ex 0;">

                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 7.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:</strong>
                        <div style="padding: 1ex 0;">
                            Not applicable.
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 8.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:</strong>
                        <div style="padding: 1ex 0;">
                            Not applicable.
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 9.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>NOTICE OF DISSOLUTION OF GROUP:</strong>
                        <div style="padding: 1ex 0;">
                            Not applicable.
                        </div>
                    </td>
                </tr>
                <tr>
                    <td valign="top" style="white-space: nowrap;"><strong>ITEM 10.</strong></td>
                    <td colspan="2" valign="top">
                        <strong>CERTIFICATION:</strong>
                        <div style="padding: 1ex 0;">
                            By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
                        </div>
                    </td>
                </tr>
            </table>
        </div>
        <div style="page-break-before: always; margin-top: 4em;">
            <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
            <div style="padding: 1em 0; text-align: center; font-size: 12pt; font-weight: bold;">SIGNATURE</div>
            <div style="padding: 1em 0 2em 0; font-size: 8pt; text-align: center;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>

                    <div style="page-break-inside: avoid; padding-bottom: 1em">
                        <table style="width: 100%; border: 0; font-size: 9pt;" border="0" cellpadding="0" cellspacing="0">
                            <tr>
                                <td valign="top" style="width: 30%;">February 14 2019</td>
                                <td valign="top" style="width: 80%;">
                                    <div style="width: 70%; margin-bottom: 1ex;">Consonance Capital Management LP </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">By:</div>
                                        <div style="display: inline-block; width: 86%; border-bottom: solid 2px black;">/s/ Consonance Capman GP LLC /s/ Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Name:</div>
                                        <div style="display: inline-block; width: 86%;">Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Title:</div>
                                        <div style="display: inline-block; width: 86%;">Manager &amp; Member</div>
                                    </div>
                                </td>
                            </tr>
                        </table>
                    </div>

                    <div style="page-break-inside: avoid; padding-bottom: 1em">
                        <table style="width: 100%; border: 0; font-size: 9pt;" border="0" cellpadding="0" cellspacing="0">
                            <tr>
                                <td valign="top" style="width: 30%;">February 14 2019</td>
                                <td valign="top" style="width: 80%;">
                                    <div style="width: 70%; margin-bottom: 1ex;">Consonance Capital Opportunity Fund Management LP</div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">By:</div>
                                        <div style="display: inline-block; width: 86%; border-bottom: solid 2px black;">/s/ Consonance Capman GP LLC /s/Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Name:</div>
                                        <div style="display: inline-block; width: 86%;">Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Title:</div>
                                        <div style="display: inline-block; width: 86%;">Manager &amp; Member</div>
                                    </div>
                                </td>
                            </tr>
                        </table>
                    </div>

                    <div style="page-break-inside: avoid; padding-bottom: 1em">
                        <table style="width: 100%; border: 0; font-size: 9pt;" border="0" cellpadding="0" cellspacing="0">
                            <tr>
                                <td valign="top" style="width: 30%;">February 14 2019</td>
                                <td valign="top" style="width: 80%;">
                                    <div style="width: 70%; margin-bottom: 1ex;">Mitchell Blutt</div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">By:</div>
                                        <div style="display: inline-block; width: 86%; border-bottom: solid 2px black;">/s/ Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Name:</div>
                                        <div style="display: inline-block; width: 86%;">Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Title:</div>
                                        <div style="display: inline-block; width: 86%;">Manager &amp; Member</div>
                                    </div>
                                </td>
                            </tr>
                        </table>
                    </div>

                    <div style="page-break-inside: avoid; padding-bottom: 1em">
                        <table style="width: 100%; border: 0; font-size: 9pt;" border="0" cellpadding="0" cellspacing="0">
                            <tr>
                                <td valign="top" style="width: 30%;">February 14 2019</td>
                                <td valign="top" style="width: 80%;">
                                    <div style="width: 70%; margin-bottom: 1ex;">Consonance Capman GP LLC</div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">By:</div>
                                        <div style="display: inline-block; width: 86%; border-bottom: solid 2px black;">/s/ Consonance Capman GP LLC /s/ Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Name:</div>
                                        <div style="display: inline-block; width: 86%;">Mitchell Blutt</div>
                                    </div>
                                    <div style="width: 70%; margin-bottom: 1ex;">
                                        <div style="display: inline-block; width: 12%;">Title:</div>
                                        <div style="display: inline-block; width: 86%;">Manager &amp; Member</div>
                                    </div>
                                </td>
                            </tr>
                        </table>
                    </div>

            <div style="padding-top: 1em; font-size: 9pt;">Attention &mdash; Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001).</div>

        </div>
        <div id="ExCorrDiv">

                    <div style="page-break-before: always; margin-top: 4em;">
                        <div style="font-weight: bold; border: solid 1px black; margin: 1ex 0; padding: 1ex 2em; width: 14em;">CUSIP No.: 69404D108</div>
                        <div style="margin: 1em 0;">
                            Item 4. Ownership:<br>Consonance Capital Master Account LP (&#8220;Consonance Master&#8221;) directly holds 2,392,074 shares of the Issuer&#8217;s Common Stock (the &#8220;Master Account Shares&#8221;).  Consonance Capital Management LP (the &#8220;Adviser&#8221;) is the investment adviser of Consonance Master, and pursuant to an investment advisory agreement (the &#8220;Advisory Agreement&#8221;), the Adviser exercises voting and investment power over the Master Account Shares held by Consonance Master.  Consonance Capman GP LLC (&#8220;Capman&#8221;) is the general partner of the Adviser and Mitchell Blutt, as the Manager &amp; Member of Capman and Chief Executive Officer of the Adviser, may be deemed to control Capman and the Adviser.  Each of the Adviser, Capman and Mr. Blutt may be deeded to beneficially own the Master Account Shares, but neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that any of the Adviser, Capman or Mr. Blutt is the beneficial owner of the Master Account Shares for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose.  <br><br>A managed account managed by Consonance Capital Opportunity Fund Management LP (&#8220;Consonance Opportunity&#8221;) directly holds 63,040 shares of the Issuer&#8217;s Common Stock (the &#8220;Managed Account Shares&#8221;).  Capman is the general partner of Consonance Opportunity and Mitchell Blutt, as the Manager &amp; Member of Capman, may be deemed to control Capman and Consonance Opportunity.  Each of Consonance Opportunity, Capman and Mr. Blutt may be deemed to beneficially own the Managed Account Shares, but neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that any of Consonance Opportunity, Capman or Mr. Blutt is the beneficial owner of the Managed Account Shares for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose.   <br><br><br>EXHIBIT 99.1	<br>JOINT FILING AGREEMENT<br>In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13G dated February 14, 2019 (including amendments thereto) with respect to the Common Stock, par value $0.001 per share, of Pacific Biosciences of California, Inc.  This Joint Filing Agreement shall be filed as an Exhibit to such Statement.  The undersigned acknowledge that each shall be responsible for the timely filing of any amendments to such joint filing and for the completeness and accuracy of the information concerning him or it contained herein and therein, but shall not be responsible for the completeness and accuracy of the information concerning the others.<br><br><br>CONSONANCE CAPITAL MANAGEMENT LP<br>By: Consonance Capman GP LLC<br>By: /s/ Mitchell Blutt<br>Name: Mitchell Blutt<br>Title: Manager &amp; Member<br><br>CONSONANCE CAPITAL OPPORTUNITY FUND MANAGEMENT LP<br>By: Consonance Capman GP LLC<br>By: /s/ Mitchell Blutt<br>Name: Mitchell Blutt<br>Title: Manager &amp; Member<br><br>CONSONANCE CAPMAN GP LLC<br>By: /s/ Mitchell Blutt<br>Name: Mitchell Blutt<br>Title: Manager &amp; Member<br><br>/s/ Mitchell Blutt<br>MITCHELL BLUTT
                        </div>
                    </div>


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</DOCUMENT>
</SEC-DOCUMENT>
