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v3.19.3.a.u2

Consolidated Statements of Cash Flows $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Cash flows from operating activities |  |  |
Net loss | $ (84,134) | $ (102,562) | $ (92,189)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Gain from Continuation Advances from Illumina | (18,000) |  |
Depreciation | 7,265 | 7,215 | 8,442
Amortization of right-of-use assets | 2,683 |  |
Amortization of debt discount and financing costs | 1,212 | 1,024 | 1,203
Stock-based compensation | 16,401 | 23,153 | 20,352
(Gain) loss from derivative | (16) | (167) | 653
Amortization and accretion for investment premium (discount) | (913) | (758) | (32)
Loss on disposition of equipment | 194 |  | 11
Loss on return of building under capital lease |  |  | 68
Changes in assets and liabilities |  |  |
Accounts receivable | (6,671) | 4,838 | (2,012)
Inventory | 3,915 | 3,623 | (8,442)
Prepaid expenses and other assets | (523) | (290) | 7,803
Accounts payable | 1,713 | (2,239) | 764
Accrued expenses | 419 | 205 | (3,986)
Deferred revenue | 2,134 | 33 | (1,033)
Operating lease liabilities | (3,428) |  |
Other liabilities | (563) | (505) | 880
Net cash used in operating activities | (78,312) | (66,430) | (67,518)
Cash flows from investing activities |  |  |
Purchase of property and equipment | (2,836) | (1,854) | (10,433)
Proceeds from disposal of property and equipment |  |  | 41
Purchase of investments | (57,727) | (122,183) | (86,339)
Sales of investments | 1,500 | 2,442 | 7,111
Maturities of investments | 121,110 | 83,180 | 88,071
Net cash provided by (used in) investing activities | 62,047 | (38,415) | (1,549)
Cash flows from financing activities |  |  |
Continuation Advances from Illumina | 18,000 |  |
Proceeds from issuance of common stock from equity plans | 8,548 | 9,652 | 8,914
Notes payable principal payoff |  |  | (4,500)
Net cash provided by financing activities | 26,548 | 107,182 | 68,809
Net increase (decrease) in cash and cash equivalents and restricted cash | 10,283 | 2,337 | (258)
Cash and cash equivalents and restricted cash at beginning of period | 23,344 | 21,007 | 21,265
Cash and cash equivalents and restricted cash at end of period | 33,627 | 23,344 | 21,007
Cash and cash equivalents at end of period | 29,627 | 18,844 | 16,507
Restricted cash at end of period | 4,000 | 4,500 | 4,500
Supplemental disclosure of cash flow information |  |  |
Interest paid | 1,400 | 1,400 | 1,687
Supplemental disclosure of non-cash investing and financing activities |  |  |
Inventory transferred to property and equipment | 2,062 | 1,871 | 1,267
Property and equipment transfered to inventory | $ (1,536) | (343) | (261)
Property and equipment paid for by landlord |  |  | 12,600
Changes in deposits for property and equipment paid in prior period |  |  | 9,694
Property and equipment returned to landlord |  |  | 1,854
At the Market Offering [Member] |  |  |
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock from offering, net of issuance costs |  |  | 11,865
Underwritten Public Equity Offering [Member] |  |  |
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock from offering, net of issuance costs |  | $ 97,530 | $ 52,530

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