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Consolidated Statements of Cash Flows
$ in Thousands
 12 Months Ended
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Cash flows from operating activities      
Net loss $ (84,134) $ (102,562) $ (92,189)
Adjustments to reconcile net loss to net cash used in operating activities      
Gain from Continuation Advances from Illumina (18,000)    
Depreciation 7,265 7,215 8,442
Amortization of right-of-use assets 2,683    
Amortization of debt discount and financing costs 1,212 1,024 1,203
Stock-based compensation 16,401 23,153 20,352
(Gain) loss from derivative (16) (167) 653
Amortization and accretion for investment premium (discount) (913) (758) (32)
Loss on disposition of equipment 194   11
Loss on return of building under capital lease 68
Changes in assets and liabilities      
Accounts receivable (6,671) 4,838 (2,012)
Inventory 3,915 3,623 (8,442)
Prepaid expenses and other assets (523) (290) 7,803
Accounts payable 1,713 (2,239) 764
Accrued expenses 419 205 (3,986)
Deferred revenue 2,134 33 (1,033)
Operating lease liabilities (3,428)    
Other liabilities (563) (505) 880
Net cash used in operating activities (78,312) (66,430) (67,518)
Cash flows from investing activities      
Purchase of property and equipment (2,836) (1,854) (10,433)
Proceeds from disposal of property and equipment     41
Purchase of investments (57,727) (122,183) (86,339)
Sales of investments 1,500 2,442 7,111
Maturities of investments 121,110 83,180 88,071
Net cash provided by (used in) investing activities 62,047 (38,415) (1,549)
Cash flows from financing activities      
Continuation Advances from Illumina 18,000    
Proceeds from issuance of common stock from equity plans 8,548 9,652 8,914
Notes payable principal payoff     (4,500)
Net cash provided by financing activities 26,548 107,182 68,809
Net increase (decrease) in cash and cash equivalents and restricted cash 10,283 2,337 (258)
Cash and cash equivalents and restricted cash at beginning of period 23,344 21,007 21,265
Cash and cash equivalents and restricted cash at end of period 33,627 23,344 21,007
Cash and cash equivalents at end of period 29,627 18,844 16,507
Restricted cash at end of period 4,000 4,500 4,500
Supplemental disclosure of cash flow information      
Interest paid 1,400 1,400 1,687
Supplemental disclosure of non-cash investing and financing activities      
Inventory transferred to property and equipment 2,062 1,871 1,267
Property and equipment transfered to inventory $ (1,536) (343) (261)
Property and equipment paid for by landlord     12,600
Changes in deposits for property and equipment paid in prior period     9,694
Property and equipment returned to landlord     1,854
At the Market Offering [Member]      
Cash flows from financing activities      
Proceeds from issuance of common stock from offering, net of issuance costs     11,865
Underwritten Public Equity Offering [Member]      
Cash flows from financing activities      
Proceeds from issuance of common stock from offering, net of issuance costs   $ 97,530 $ 52,530