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Commitments and Contingencies (Narrative) (Details)
 12 Months Ended
Jun. 22, 2020
item
Jul. 22, 2015
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
May 01, 2020
USD ($)
May 01, 2019
USD ($)
Oct. 31, 2015
USD ($)
Jul. 31, 2015
Commitments and Contingencies [Line Items]                
Long-term restricted cash     $ 3,500,000 $ 4,000,000 $ 3,500,000 $ 4,000,000.0 $ 4,500,000  
Rent payments     7,200,000 7,000,000.0        
Operating lease cost     6,200,000 $ 6,200,000        
Additional liability associated with indemnification obligations     $ 0          
1305 O’Brien Drive, Menlo Park, California [Member]                
Commitments and Contingencies [Line Items]                
Renewal term     5 years          
Weighted average remaining lease term     6 years 9 months 18 days          
Weighted average discount rate     7.90%          
PacBio IPR Petitions [Member]                
Commitments and Contingencies [Line Items]                
Number of petitions | item 2              
O’Brien Lease Agreement [Member]                
Commitments and Contingencies [Line Items]                
Lease term               132 months
Rent expense first twelve months   $ 540,000            
Rent expense last twelve months   $ 711,000            
Period in which payment must be received without incurring late charge   5 days            
Late charge, percent   5.00%            
Amount not paid after written notice, bear interest from date due until date paid, period   10 days            
O’Brien Lease Agreement [Member] | Prime Rate [Member]                
Commitments and Contingencies [Line Items]                
Basis spread on variable rate   2.00%