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Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenue:      
Total revenue $ 78,893 $ 90,891 $ 78,626
Cost of Revenue:      
Total cost of revenue 46,327 56,315 53,530
Gross profit 32,566 34,576 25,096
Operating Expense:      
Research and development 64,152 59,630 62,594
Sales, general and administrative 72,799 75,491 63,489
Total operating expense 136,951 135,121 126,083
Operating loss (104,385) (100,545) (100,987)
Gain from Reverse Termination Fee from Illumina 98,000    
Gain from Continuation Advances from Illumina 34,000 18,000  
Interest expense (267) (2,611) (2,423)
Other income, net 2,055 1,022 848
Net income (loss) 29,403 (84,134) (102,562)
Other comprehensive income (loss):      
Unrealized gain (loss) on investments 80 41 (4)
Comprehensive income (loss) $ 29,483 $ (84,093) $ (102,566)
Net income (loss) per share:      
Basic $ 0.18 $ (0.55) $ (0.76)
Diluted $ 0.17 $ (0.55) $ (0.76)
Weighted average shares outstanding used in calculating net income (loss) per share      
Basic 165,187 152,527 135,094
Diluted 174,970 152,527 135,094
Product [Member]      
Revenue:      
Total revenue $ 65,424 $ 77,742 $ 66,355
Cost of Revenue:      
Total cost of revenue 35,424 44,771 42,053
Service and Other [Member]      
Revenue:      
Total revenue 13,469 13,149 12,271
Cost of Revenue:      
Total cost of revenue $ 10,903 $ 11,544 $ 11,477