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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Cash flows from operating activities      
Net income (loss) $ 29,403 $ (84,134) $ (102,562)
Adjustments to reconcile net loss to net cash used in operating activities      
Gain from Continuation Advances from Illumina (34,000) (18,000)  
Depreciation 6,428 7,265 7,215
Amortization of right-of-use assets 2,876 2,683  
Amortization of debt discount and financing costs 129 1,212 1,024
Stock-based compensation 17,533 16,401 23,153
Gain (loss) from derivative   (16) (167)
Amortization and accretion for investment premium (discount) (107) (913) (758)
Loss on disposition of equipment   194  
Changes in assets and liabilities      
Accounts receivable (1,603) (6,671) 4,838
Inventory (1,096) 3,915 3,623
Prepaid expenses and other assets (1,063) (523) (290)
Accounts payable (5,072) 1,713 (2,239)
Accrued expenses 4,102 2,333 183
Deferred revenue 729 2,134 33
Operating lease liabilities (3,802) (3,428)  
Other liabilities 5,046 (2,477) (483)
Net cash provided by (used in) operating activities 19,503 (78,312) (66,430)
Cash flows from investing activities      
Purchase of property and equipment (1,039) (2,836) (1,854)
Purchase of investments (373,283) (57,727) (122,183)
Sales of investments 1,400 1,500 2,442
Maturities of investments 153,600 121,110 83,180
Net cash provided by (used in) investing activities (219,322) 62,047 (38,415)
Cash flows from financing activities      
Continuation Advances from Illumina 34,000 18,000  
Proceeds from issuance of common stock from equity plans 46,360 8,548 9,652
Notes payable principal payoff (16,000)    
Proceeds from issuance of common stock from underwritten public equity offerings, net of issuance costs 187,479   97,530
Net cash provided by (used in) in investing activities 251,839 26,548 107,182
Net increase in cash and cash equivalents and restricted cash 52,020 10,283 2,337
Cash and cash equivalents and restricted cash at beginning of period 33,927 23,644 21,307
Cash and cash equivalents and restricted cash at end of period 85,947 33,927 23,644
Cash and cash equivalents at end of period 81,611 29,627 18,844
Restricted cash at end of period 4,336 4,300 4,800
Supplemental disclosure of cash flow information      
Interest paid 491 1,400 1,400
Supplemental disclosure of non-cash investing and financing activities      
Inventory transferred to property and equipment 1,097 2,062 1,871
Property and equipment transferred to inventory $ (919) $ (1,536) $ (343)