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Commitments and Contingencies (Narrative) (Details)
 3 Months Ended
Jun. 22, 2020
item
Jul. 22, 2015
USD ($)
Mar. 31, 2021
USD ($)
Mar. 31, 2020
USD ($)
Dec. 31, 2020
USD ($)
May 01, 2020
USD ($)
May 01, 2019
USD ($)
Mar. 31, 2019
USD ($)
Oct. 31, 2015
USD ($)
Commitments and Contingencies [Line Items]                  
Long-term restricted cash     $ 3,500,000   $ 3,500,000 $ 3,500,000 $ 4,000,000.0 $ 4,500,000 $ 4,500,000
Rent payments     1,800,000            
Operating lease cost     1,600,000 $ 1,600,000          
Additional liability associated with indemnification obligations     $ 0            
1305 O’Brien Drive, Menlo Park, California [Member]                  
Commitments and Contingencies [Line Items]                  
Renewal term     5 years            
Weighted average remaining lease term     6 years 7 months 6 days            
Weighted average discount rate     7.90%            
PacBio IPR Petitions [Member]                  
Commitments and Contingencies [Line Items]                  
Number of petitions | item 2                
O’Brien Lease Agreement [Member]                  
Commitments and Contingencies [Line Items]                  
Lease term   132 months              
Rent expense first twelve months   $ 540,000              
Rent expense last twelve months   $ 711,000              
Period in which payment must be received without incurring late charge   5 days              
Late charge, percent   5.00%              
Amount not paid after written notice, bear interest from date due until date paid, period   10 days              
O’Brien Lease Agreement [Member] | Prime Rate [Member]                  
Commitments and Contingencies [Line Items]                  
Basis spread on variable rate   2.00%