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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2019
Cash flows from operating activities      
Net income (loss) $ (87,435) $ 1,262  
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities      
Loss (gain) from Continuation Advances 52,000 (34,000) $ (18,000)
Depreciation 1,606 1,657  
Amortization of operating lease right-of-use assets 790 709  
Amortization of debt discount and financing costs 74 129  
Stock-based compensation 10,165 4,032  
Amortization (accretion) from investment premium (discount) 565 (83)  
Changes in assets and liabilities      
Accounts receivable 3,931 7,909  
Inventory (2,556) (3,374)  
Prepaid expenses and other assets (675) (58)  
Accounts payable 153 (4,129)  
Accrued expenses (2,680) 4,721  
Deferred revenue 5,004 (970)  
Operating lease liabilities (1,066) (931)  
Other liabilities (2,980) 489  
Deferred gain from Reverse Termination fee   98,000  
Net cash provided by (used in) operating activities (23,104) 75,363  
Cash flows from investing activities      
Purchase of property and equipment (401) (117)  
Purchase of investments (64,426) (72,960)  
Sales of investments 4,597    
Maturities of investments 68,400 18,750  
Net cash provided by (used in) investing activities 8,170 (54,327)  
Cash flows from financing activities      
Continuation Advances (52,000) 34,000  
Notes payable principal payoff   (16,000)  
Proceeds from issuance of Convertible Senior Notes, net of issuance costs 895,624    
Issuance costs paid for underwritten public equity offering (246)    
Proceeds from issuance of common stock from equity plans 22,343 199  
Net cash provided by financing activities 865,721 18,199  
Net increase in cash and cash equivalents and restricted cash 850,787 39,235  
Cash and cash equivalents and restricted cash at beginning of period 85,947 33,627  
Cash and cash equivalents and restricted cash at end of period 936,734 72,862 $ 33,627
Cash and cash equivalents at end of period 932,398 68,862  
Restricted cash at end of period $ 4,336 $ 4,000