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Business Acquisitions (Narrative) (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 3 Months Ended | 9 Months Ended
--- | --- | --- | --- | ---
Sep. 20, 2021 | Jul. 20, 2021 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Business Acquisition [Line Items] |  |  |  |  |  |
Fair value of contingent consideration |  |  | $ 168,574 |  | $ 168,574 |
Proceeds From Issuance Of Common Stock |  |  |  |  | 30,121 | $ 14,174
Issuance of common stock in Private Placement, net of issuance costs |  |  | 294,845 |  | 294,845 |
Acquisition-related costs |  |  | 30,726 |  | 30,726 |
Stock-based compensation expense |  |  | 35,820 | $ 4,992 | 61,790 | $ 12,258
Income tax benefit from reduction in deferred tax assets valuation allowance |  |  |  |  | 94,800 |
Goodwill |  |  | 411,533 |  | 411,533 |
Omniome stock awards related to acquisition [Member] |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |
Total cash paid | $ 7,400 |  |  |  |  |
Fair value of share consideration | 6,300 |  |  |  |  |
Fair value of contingent consideration | $ 5,200 |  |  |  |  |
Issuance of common stock | 226,811 |  |  |  |  |
Consideration | $ 18,900 |  |  |  |  |
Circulomics, Inc [Member] |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |
Total cash paid |  | $ 29,500 |  |  |  |
Allocation of purchase price to intangible assets |  | 11,360 |  |  |  |
Goodwill |  | $ 19,309 |  |  |  |
Finite-Lived Intangible Assets, Gross |  |  | $ 11,360 |  | 11,360 |
Omniome, Inc [Member] |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |
Total cash paid | 315,703 |  |  |  |  |
Fair value of share consideration | 249,435 |  |  |  |  |
Fair value of contingent consideration | $ 168,574 |  |  |  |  |
Issuance of common stock | 8,911,580 |  |  |  |  |
Consideration | $ 714,789 |  |  |  |  |
Price Per Share | $ 26.75 |  |  |  |  |
Issuance of common stock in Private Placement, net of issuance costs shares | 11,214,953 |  |  |  |  |
Proceeds From Issuance Of Common Stock | $ 294,800 |  |  |  |  |
Estimated issuance costs | 5,200 |  |  |  |  |
Acquisition-related costs | 11,600 |  |  |  | 11,600 |
Stock-based compensation expense | 18,900 |  |  |  |  |
Income tax benefit from reduction in deferred tax assets valuation allowance | 92,200 |  |  |  |  |
Pro forma adjustment related to acquiree's acquisition-related costs | 16,700 |  |  |  |  |
Since the date of acquisition, revenues |  |  |  |  | 0 |
Since the date of acquisition, net loss |  |  |  |  | $ 1,600 |
Goodwill | 392,224 |  |  |  |  |
Achievement of milestone [Member] | Omniome stock awards related to acquisition [Member] |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |
Stock options issued by PacBio in replacement of Omniome’s unvested options | 4,100 |  |  |  |  |
Achievement of milestone [Member] | Omniome, Inc [Member] |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |
Total cash paid | 100,000 |  |  |  |  |
Fair value of share consideration | 100,000 |  |  |  |  |
Fair value of contingent consideration | 200,000 |  |  |  |  |
In Process Research and Development, Intangible [Member] | Omniome, Inc [Member] |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |
Allocation of purchase price to intangible assets | 400,000 |  |  |  |  |
Finite-Lived Intangible Assets, Gross | $ 400,000 |  |  |  |  |

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