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Commitments and Contingencies (Narrative) (Details)		3 Months Ended		9 Months Ended
	Jun. 22, 2020 item	Sep. 30, 2021 USD ($)	Sep. 30, 2020 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2020 USD ($)	Sep. 20, 2021 USD ($)	Dec. 31, 2020 USD ($)	Oct. 31, 2015 USD ($)
Commitments and Contingencies [Line Items]
Long-term restricted cash		$ 4,560,000		$ 4,560,000			$ 3,500,000
Weighted average remaining lease term		6 years		6 years
Weighted average discount rate		6.80%		6.80%
Rent payments		$ 1,800,000		$ 5,500,000
Operating lease cost		1,600,000	$ 1,600,000	4,700,000	$ 4,700,000
Additional liability associated with indemnification obligations		0		0
Operating Lease, Right-of-Use Asset		45,862,000		45,862,000			$ 29,951,000
Operating Lease, Liability		57,082,000		57,082,000
Omniome, Inc [Member]
Commitments and Contingencies [Line Items]
Long-term restricted cash		1,600,000		1,600,000
Operating Lease, Right-of-Use Asset						$ 18,100,000
Operating Lease, Liability						$ 18,100,000
PacBio IPR Petitions [Member]
Commitments and Contingencies [Line Items]
Number of petitions | item	2
O’Brien Lease Agreement [Member]
Commitments and Contingencies [Line Items]
Long-term restricted cash		$ 3,000,000.0		$ 3,000,000.0				$ 4,500,000

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Amount of single lease cost, calculated by allocation of remaining cost of lease over remaining lease term. Includes, but is not limited to, single lease cost, after impairment of right-of-use asset, calculated by amortization of remaining right-of-use asset and accretion of lease liability.

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