<SEC-DOCUMENT>0001299130-21-000103.txt : 20210301
<SEC-HEADER>0001299130-21-000103.hdr.sgml : 20210301
<ACCEPTANCE-DATETIME>20210226182841
ACCESSION NUMBER:		0001299130-21-000103
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20210301
DATE AS OF CHANGE:		20210226
EFFECTIVENESS DATE:		20210301

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-253669
		FILM NUMBER:		21692457

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>pacb-20210226xs8.htm
<DESCRIPTION>S-8
<TEXT>
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			S-8
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	<body><div style="margin-left:54pt;margin-right:54pt;">
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">As filed with the Securities and Exchange Commission on February </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">26, </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">2021</font>
		</p>
		<p style="margin:0pt;text-align:right;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Registration No. 333- </font>
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		<p style="margin:0pt;border-bottom:1pt none #D9D9D9 ;line-height:normal;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;">&#xFEFF;</font>
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			<font style="display: inline;">&nbsp;</font>
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		<p style="margin:4pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:18pt;">UNITED STATES </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:18pt;">SECURITIES AND EXCHANGE COMMISSION </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;">Washington, D.C. 20549 </font>
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		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
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		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 18pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:18pt;">FORM S-8&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;">REGISTRATION STATEMENT </font><font style="display: inline;font-family:Times New Roman;font-weight:bold;text-transform:uppercase;color:#000000;">Under The Securities Act of 1933 </font>
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		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
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			<font style="display: inline;">&nbsp;</font>
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		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 24pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:24pt;">Pacific Biosciences of California, Inc. </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">(Exact name of registrant as specified in its charter) </font>
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		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
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			<font style="display: inline;">&nbsp;</font>
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						&nbsp;</p>
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					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:8pt;">&#xFEFF;</font></p>
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				<td valign="bottom" style="width:00.18%;padding:0pt;">
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						&nbsp;</p>
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						&nbsp;</p>
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				<td valign="top" style="width:62.38%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Delaware</font></p>
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				<td valign="bottom" style="width:00.18%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
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				<td valign="top" style="width:37.44%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">16-1590339</font></p>
				</td>
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				<td valign="top" style="width:62.38%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(State or other jurisdiction of</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">incorporation or organization)</font></p>
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					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
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				<td valign="top" style="width:37.44%;padding:0pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(I.R.S. Employer</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Identification No.)</font></p>
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		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
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		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">1305 O&#x2019;Brien Drive </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Menlo Park, CA 94025 </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(Address of Principal Executive Offices) (Zip Code) </font>
		</p>
		<p style="margin:0pt 0pt 2pt;border-bottom:1pt solid #000000 ;line-height:normal;text-align:center;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;">&nbsp;&nbsp;</font>
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		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
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		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Pacific Biosciences of California, Inc. 2010 Employee Stock Purchase Plan </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:8pt;"> (Full title of the plan) </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Christian O. Henry</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Chief Executive Officer and President</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">1305 O&#x2019;Brien Drive </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Menlo Park, CA 94025 </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">(Name and address of agent for service) </font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;"> (650) 521-8000</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:8pt;">(Telephone number, including area code, of agent for service) </font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-style:italic;font-size:10pt;">Copies to: </font>
		</p>
		<p style="margin:6pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Donna M. Petkanics </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Andrew D. Hoffman </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Wilson Sonsini Goodrich &amp; Rosati, P.C. </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">650 Page Mill Road </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">Palo Alto, CA 94304 </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">(650) 493-9300</font>
		</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#x201C;large accelerated filer,&#x201D; &#x201C;accelerated filer,&#x201D; </font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#x201C;smaller reporting company&#x201D; and &#x201C;emerging growth company&#x201D; in Rule 12b-2 of the Exchange Act. </font>
		</p>
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					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
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				<td valign="bottom" style="width:01.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
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						&nbsp;</p>
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					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
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					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
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					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
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					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Large accelerated filer</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:292.60pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2610;</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:100.90pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Accelerated filer</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:10.10pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:85.75pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:297.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:105.95pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:15.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:85.75pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Non-accelerated filer</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:292.60pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2612;</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:100.90pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Smaller reporting company</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:10.10pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2612;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:85.75pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:297.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:105.95pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:15.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:85.75pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:292.60pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:100.90pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Emerging growth company</font></p>
				</td>
				<td valign="bottom" style="width:05.05pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:10.10pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Segoe UI Symbol;color:#000000;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. </font><font style="display: inline;font-family:Segoe UI Symbol;font-size:10pt;">&#x2610;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;">&nbsp;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">CALCULATION OF REGISTRATION FEE </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:12.18%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:12.18%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="9" valign="top" style="width:100.00%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;border-top:1pt solid #000000 ;line-height:106.67%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Title of securities</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">to be registered</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Amount</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">to be</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">registered (1)</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Proposed</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">maximum</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">offering price</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">per share</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Proposed</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">maximum</font><br /><font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">aggregate</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">offering price</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:12.18%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Amount of</font></p>
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">registration fee</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:36.08%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:106.67%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Common stock, $0.001 par value per share, to be issued under the 2010 Employee Stock Purchase Plan</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:13.76%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">3,845,871</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> (2)</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:11.84%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">$28.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">14</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> (3)</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:15.96%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:7pt;">&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">$1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">08,222</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">809.94</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:02.54%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:12.18%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:7pt;">&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">$1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">807</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">11</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="9" valign="top" style="width:100.00%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;border-top:1pt solid #000000 ;line-height:106.67%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="9" valign="top" style="width:100.00%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;border-top:1pt solid #000000 ;line-height:106.67%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:05.30%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="top" style="width:94.70%;padding:0pt 6.5pt 0pt 6.5pt;height:1.00pt">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:05.30%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1)</font></p>
				</td>
				<td colspan="2" valign="top" style="width:94.70%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;text-align:justify;text-justify:inter-ideograph;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Rule 416(a) of the Securities Act of 1933, as amended, this Registration Statement shall also cover any additional shares of the Registrant&#x2019;s common stock that become issuable under the 2010 Employee Stock Purchase Plan (&#x201C;2010 ESPP&#x201D;) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of the Registrant&#x2019;s outstanding shares of </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">common stock.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:05.30%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2)</font></p>
				</td>
				<td colspan="2" valign="top" style="width:94.70%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Reflects </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">an automatic annual increase on January 1, 2021 to the number of shares of the Registrant&#x2019;s common stock reserved for issuance under the 2010 ESPP, which annual increase is provided for in the 2010 ESPP</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="width:05.36%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3)</font></p>
				</td>
				<td valign="top" style="width:94.64%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Estimated </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">in accordance with Rule 457(c) and (h) under the Securities Act of 1933, as amended, solely for purposes of calculating the registration fee on the basis of 85% of $</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">33.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">10</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, the average of the high and low prices of Registrant</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2019;</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">s common stock as reported on the NASDAQ Global Select Market on February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">5</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021.&nbsp; </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Pursuant to the 2010 ESPP, which plan is incorporated by reference herein, the purchase price of the shares of common stock will be 85% of the lower of the fair market value of the common stock on the first trading day of the offering period or on the last day of the offering period.</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="width:05.36%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:94.64%;padding:0pt 6.5pt 0pt 6.5pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
		</table></div><hr style="border-bottom-style:solid;width:100%;height:2.25pt; ;color:#a0a0a0" align="center"></hr>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">EXPLANATORY NOTE</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">This Registration Statement is being filed for the purpose of registering an additional </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">3,845,871 </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">shares of common stock that were reserved for issuance under the 2010 ESPP. The Registrant previously filed with the Securities and Exchange Commission (the &#x201C;Commission&#x201D;) registration statements on Form S-8 on October 29, 2010 (SEC File No. 333-170211), March 1, 2012 (SEC File No.</font><font style="display: inline;font-family:Times New Roman;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">333-179810), January 17, 2013 (SEC File No. 333-186065), January 21, 2014 (SEC File No. 333-193437), January 23, 2015 (SEC File No. 333-201678), January 28, 2016 (SEC File No. 333-209157), January 26, 2017 (SEC File No. 333-215746), January 25, 2018 (SEC File No. 333-222696), January 25, 2019 (SEC File No. 333-229368), and January 24, 2020 (SEC File No.</font><font style="display: inline;font-family:Times New Roman;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">333-236061) (the &#x201C;Prior Registration Statements&#x201D;) registering shares of Common Stock issuable under the 2010 ESPP. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General Instruction E of Form S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except for Items 3 and 8, which are being updated by this Registration Statement.</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;;font-size: 10pt"><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">PART I </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">INFORMATION REQUIRED IN THE PROSPECTUS </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The documents containing the information specified in Item 1 and Item 2 of this Registration Statement on Form S-8 (the &#x201C;Registration Statement&#x201D;) will be sent or given to employees, officers, directors or others as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the &#x201C;Securities Act&#x201D;). In accordance with the rules and regulations of the Commission and the instructions to the Registration Statement, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424. </font>
		</p>
		<p style="margin:24pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">PART II </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">INFORMATION REQUIRED IN REGISTRATION STATEMENT</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="top" style="width:09.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 3.</font></p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Incorporation of Documents by Reference. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pacific Biosciences of California, Inc. (the &#x201C;Registrant&#x201D;) hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission: </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1) </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Registrant&#x2019;s Annual Report on Form </font><a href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1299130/000129913021000098/pacb-20201231x10k.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">10-K</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> for its fiscal year ended December 31, 2020, filed with the Commission on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">February 26, </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">2021 pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the &#x201C;Exchange Act&#x201D;); </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2) All other reports filed with the Commission pursuant to Sections 13(a) or 15(d) of the Exchange</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> Act since the end of the fiscal year covered by the Registrant&#x2019;s Annual Report referred to in (1) above; and </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3) The description of the Registrant&#x2019;s Common Stock contained in the Registrant&#x2019;s Registration Statement on </font><a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312510224288/d8a12b.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;color:#0000EE;font-size:10pt;">Form 8-A</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> (File No. 001-34899) filed with the Commission on October 6, 2010, pursuant to Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose of updating such description. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="top" style="width:09.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 4.</font></p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Description of Securities. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable. </font>
		</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="top" style="width:09.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 5.</font></p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Interests of Named Experts and Counsel. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable. </font>
		</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="top" style="width:09.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 6.</font></p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Indemnification of Directors and Officers. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Section 145 of the Delaware General Corporation Law authorizes a corporation&#x2019;s board of directors to grant, and authorizes a court to award, indemnity to officers, directors and other corporate agents. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">As permitted by Section 102(b)(7) of the Delaware General Corporation Law, the Registrant&#x2019;s certificate of incorporation includes provisions that eliminate the personal liability of its directors for monetary damages for breach of their fiduciary duty as directors. To the extent Section 102(b)(7) is interpreted, or the Delaware General Corporation Law is amended, to allow similar protections for officers of a corporation, such provisions of the Registrant&#x2019;s certificate of incorporation shall also extend to those persons. </font>
		</p><hr style="border-bottom-style:solid;width:100%;height:2.25pt; ;color:#a0a0a0" align="center"></hr>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">In addition, as permitted by Section 145 of the Delaware General Corporation Law, the bylaws of the Registrant to be effective upon completion of this offering provide that: </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant shall indemnify its directors and officers for serving the Registrant in those capacities or for serving other business enterprises at the Registrant&#x2019;s request, to the fullest extent permitted by Delaware law. Delaware law provides that a corporation may indemnify such person if such person acted in good faith and in a manner such person reasonably believed to be in or not opposed to the best interests of the Registrant and, with respect to any criminal proceeding, had no reasonable cause to believe such person&#x2019;s conduct was unlawful. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant may, in its discretion, indemnify employees and agents in those circumstances where indemnification is permitted by applicable law. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant is required to advance expenses, as incurred, to its directors and officers in connection with defending a proceeding, except that such director or officer shall undertake to repay such advances if it is ultimately determined that such person is not entitled to indemnification. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant will not be obligated pursuant to the bylaws to indemnify a person with respect to proceedings initiated by that person, except with respect to proceedings authorized by the Registrant&#x2019;s board of directors or brought to enforce a right to indemnification. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The rights conferred in the bylaws are not exclusive, and the Registrant is authorized to enter into indemnification agreements with its directors, officers, employees and agents and to obtain insurance to indemnify such persons. </font></p>
				</td>
			</tr>
		</table></div>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="middle" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
				</td>
				<td valign="top" style="width:04.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#x2022;</font></p>
				</td>
				<td valign="top" style="width:01.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">The Registrant may not retroactively amend the bylaw provisions to reduce its indemnification obligations to directors, officers, employees and agents. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">The Registrant&#x2019;s policy is to enter into separate indemnification agreements with each of its directors and officers that provide the maximum indemnity allowed to directors and executive officers by Section 145 of the Delaware General Corporation Law and also provides for certain additional procedural protections. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">These indemnification provisions and the indemnification agreements entered into between the Registrant and its officers and directors may be sufficiently broad to permit indemnification of the Registrant&#x2019;s officers and directors for liabilities (including reimbursement of expenses incurred) arising under the Securities Act. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0.25pt;">
			<tr>
				<td valign="top" style="width:09.00%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 7.</font></p>
				</td>
				<td valign="top" style="width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Exemption from Registration Claimed. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Not applicable. </font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:540.30pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:72.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:468.30pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:72.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 8.</font></p>
				</td>
				<td valign="top" style="width:468.30pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 7.4pt;line-height:105.83%;text-indent:7.4pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Exhibits. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:31.15pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:453.65pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:1.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Exhibit</font></p>
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Number</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Description</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:8pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312510221497/dex41.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;color:#0000EE;font-size:10pt;">Specimen Common Stock Certificate of Registrant (which is incorporated herein by reference to Exhibit 4.1 to the Registrant&#x2019;s Registration Statement on Form S-1, as amended (Registration No. 333-168858), as declared effective on October 26, 2010 (&#x201C;Registrant&#x2019;s Form S-1&#x201D;)) </font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4.2</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000129913020000008/pacb-20191231xex4_2.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Description of the Registrant&#x2019;s securities registered under Section 12 of the Exchange Act (which is incorporated herein by reference to Exhibit 4.2 to the Registrant&#x2019;s Form 10-K filed on February 28, 2020)</font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:9.65pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:9.65pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:9.65pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">4.3+</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312510189512/dex105.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;color:#0000EE;font-size:10pt;">2010 Employee Stock Purchase Plan and forms of agreement thereunder (which are incorporated herein by reference to Exhibit 10.5 to the Registrant&#x2019;s Form S-1) </font></a></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">5.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="pacb-20210226xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Opinion of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation</font></a><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> &nbsp; </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">23.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="pacb-20210226xex23_1.htm" style="-sec-extract:exhibit"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of Independent Registered Public Accounting Firm&nbsp;&nbsp; </font></a><font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">23.2</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Consent of Wilson Sonsini Goodrich &amp; Rosati, Professional Corporation (contained in Exhibit 5.1 hereto) </font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:31.15pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:473.35pt;padding:0.3pt 0.3pt 0.3pt 0.3pt;height:6.00pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:31.15pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">24.1</font></p>
				</td>
				<td valign="bottom" style="width:19.70pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:453.65pt;background-color: #CCEEFF;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<a href="#POA"><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Power of Attorney (contained on signature page hereto)</font></a><font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td colspan="4" valign="top" style="width:16.36%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 12pt">
						<font style="display: inline;">Specimen Common Stock Certificate of Registrant (which is incorporated herein by reference to the Exhibit 4.1 to the Registrant&#x2019;s Registration Statement on Form S-1, as amended (Registration No. 333-168858), as declared effective on October 26, 2010 (&#x201C;Registrant&#x2019;s Form S-1&#x201D;))</font></p>
				</td>
				<td valign="top" style="width:02.64%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="top" style="width:81.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr></table>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td colspan="2" valign="top" style="border-right:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;border-left:1pt solid #000000 ;width:13.98%;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="top" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;width:81.00%;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt solid #000000 ;border-top:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;width:01.86%;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">+</font></p>
				</td>
				<td colspan="4" valign="top" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-top:1pt solid #000000 ;border-bottom:1pt solid #000000 ;width:auto;padding:0.3pt 0.3pt 0.3pt 0.3pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Indicates management contract or compensatory plan, contract or arrangement. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;color:#000000;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:536.45pt;margin-left:3pt;">
			<tr>
				<td valign="top" style="width:67.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:468.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:67.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Item 9.</font></p>
				</td>
				<td valign="top" style="width:468.95pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:106.67%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">Undertakings. </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:6pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">A. The undersigned Registrant hereby undertakes: </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(i) To include any prospectus required by Section 10(a)(3) of the Securities Act; </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(ii) To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the &#x201C;Calculation of Registration Fee&#x201D; table in the effective registration statement; and </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-style:italic;font-size:10pt;">Provided, however</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement. </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-family:Times New Roman;font-style:italic;font-size:10pt;">bona fide</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> offering thereof. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant&#x2019;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&#x2019;s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-family:Times New Roman;font-style:italic;font-size:10pt;">bona fide</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;"> offering thereof. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 11pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;;font-size: 11pt"><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:11pt;"></font>
		</p>
		<p style="margin:0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">SIGNATURES </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 202</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">1</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="right" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:20.45pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:08.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:198.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:100%;font-family:Arial;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:20.45pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td valign="middle" style="width:198.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="3" valign="top" style="width:226.95pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:10pt;">PACIFIC BIOSCIENCES OF CALIFORNIA, INC.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:20.45pt;height:12.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:206.50pt;height:12.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:20.45pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">By:</font></p>
				</td>
				<td valign="bottom" style="width:08.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="top" style="width:198.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Eric E. Schaefer</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:20.45pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:198.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Eric E. Schaefer</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:20.45pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:198.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Vice President and Chief Accounting Officer </font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:24pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">&#xFEFF;</font>
		</p>
		<p style="margin:24pt 0pt 0pt;text-align:center;line-height:100%;font-family:Arial;font-size: 10pt">
			<a name="POA"></a><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:10pt;">POWER OF ATTORNEY </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints </font><font style="display: inline;font-family:Times New Roman;color:#000000;font-size:10pt;">Christian O. Henry, Susan G. Kim, Brett Atkins and Eric E. Schaefer</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, jointly and severally, as his or her true and lawful attorneys-in-fact and agents with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign the Registration Statement on Form S-8 of Pacific Biosciences of California, Inc. and any or all amendments (including post-effective amendments) thereto, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;font-family:Arial;font-size: 10pt">
			<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated below: </font>
		</p>
		<p style="margin:0pt;line-height:100%;font-family:Arial;font-size: 12pt">
			<font style="display: inline;font-family:Times New Roman;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width:461.80pt;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="bottom" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:160.70pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Signature</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="bottom" style="width:138.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Title</font></p>
				</td>
				<td colspan="3" valign="bottom" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="bottom" style="width:143.25pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 8pt">
						<font style="display: inline;font-family:Times New Roman;font-weight:bold;color:#000000;font-size:8pt;">Date</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="5" valign="middle" style="width:146.50pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="6" valign="middle" style="width:154.60pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">Christian O. Henry</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Christian O. Henry</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director, Chief Executive Officer</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">and President (Principal Executive Officer)</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="5" valign="middle" style="width:146.50pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="6" valign="middle" style="width:154.60pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Susan G. Kim</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Susan G. Kim</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chief Financial Officer </font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">(Principal Financial Officer)</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
				</td>
				<td colspan="5" valign="middle" style="width:146.50pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="6" valign="middle" style="width:154.60pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Eric E. Schaefer</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Eric E. Schaefer</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Vice President and Chief Accounting Officer (Principal Accounting Officer)</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:11.35pt;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;height:46.80pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ John F. Milligan</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">John F. Milligan</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 0.55pt;line-height:105.83%;text-indent: -0.55pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Chairman of the Board of Directors</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ David Botstein</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">David Botstein</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:11.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.25pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr></table>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
		<table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;width:461.80pt;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:160.70pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
				</td>
				<td colspan="5" valign="middle" style="width:146.50pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="6" valign="middle" style="width:154.60pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ William W. Ericson</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">William W. Ericson</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:09.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:08.50pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:09.85pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:143.35pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Michael Hunkapiller</font></p>
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Michael Hunkapiller</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:09.85pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.35pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;overflow: hidden;">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:08.50pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="2" valign="middle" style="width:09.85pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:143.35pt;height:4.75pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Randall S. Livingston</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Randall S. Livingston</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:09.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="middle" style="width:143.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="5" valign="middle" style="width:146.50pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="5" valign="middle" style="width:153.20pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Marshall L. Mohr</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Marshall L. Mohr</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:138.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:09.85pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.35pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:15.65pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Kathy Ordo&#xF1;ez</font></p>
				</td>
				<td colspan="2" rowspan="2" valign="bottom" style="width:08.50pt;height:15.65pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" rowspan="2" valign="middle" style="width:138.00pt;height:15.65pt;padding:0pt 3.6pt;">
					<p style="margin:6pt 0pt 0pt 10.1pt;text-indent: -10.1pt;line-height:100%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td colspan="2" rowspan="2" valign="middle" style="width:09.85pt;height:15.65pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="3" rowspan="2" valign="middle" style="width:143.35pt;height:15.65pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 0.5pt;line-height:105.83%;text-indent: -0.5pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:160.70pt;height:15.65pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Kathy Ordo&#xF1;ez</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="middle" style="width:161.05pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 1pt">
						<font style="display: inline;font-family:Times New Roman;color:#000000;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="3" valign="middle" style="width:143.55pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td colspan="5" valign="middle" style="width:155.25pt;height:6.00pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="middle" style="width:161.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">&#xFEFF;</font></p>
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">/s/ Lucy Shapiro</font></p>
					<p style="margin:0pt 0pt 1pt;line-height:105.83%;text-align:center;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Lucy Shapiro</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:08.50pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="middle" style="width:137.65pt;padding:0pt 3.6pt;">
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt 0pt 0pt 10pt;line-height:105.83%;text-indent: -10pt;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">Director</font></p>
				</td>
				<td valign="middle" style="width:09.05pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="4" valign="middle" style="width:144.15pt;padding:0pt 3.6pt;">
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 12pt">
						&nbsp;</p>
					<p style="margin:0pt;line-height:105.83%;font-family:Arial;font-size: 10pt">
						<font style="display: inline;font-family:Times New Roman;font-size:10pt;">February </font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">26</font><font style="display: inline;font-family:Times New Roman;font-size:10pt;">, 2021</font></p>
				</td>
			</tr>
		</table></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>pacb-20210226xex5_1.htm
<DESCRIPTION>EX-5.1
<TEXT>
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			Exhibit 5.1 WSGR opinion
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			<font style="display: inline;font-size:11pt;">Exhibit 5.1</font>
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			<font style="display: inline;">&#xFEFF;</font>
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			<font style="display: inline;">&#xFEFF;</font>
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		<p style="margin:0pt;text-indent:0pt;text-align:center;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">Wilson Sonsini Goodrich &amp; Rosati</font>
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			<font style="display: inline;font-size:11pt;">Professional Corporation</font>
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			<font style="display: inline;font-size:11pt;">650 Page Mill Road</font>
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			<font style="display: inline;font-size:11pt;">Palo Alto, CA 94304-1050</font>
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		<p style="margin:12pt 0pt 0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
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			<font style="display: inline;">February </font><font style="display: inline;">26</font><font style="display: inline;">, 2021</font>
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			<font style="display: inline;font-size:12pt;">&#xFEFF;</font>
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			<font style="display: inline;color:#000000;">Pacific Biosciences of California, Inc. </font>
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		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">1305 O&#x2019;Brien Drive </font>
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			<font style="display: inline;">Menlo Park, CA 94025 </font>
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			<font style="display: inline;">&nbsp;</font>
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						<font style="display: inline;">&#xFEFF;</font><a name="_Hlk47475878"></a><font style="display: inline;">&nbsp;</font></p>
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					<p style="margin:0pt;line-height:106.67%;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Re:</font></p>
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					<p style="margin:0pt;line-height:106.67%;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Registration Statement on&nbsp;Form&nbsp;S-8</font></p>
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			<font style="display: inline;color:#000000;">Ladies and Gentlemen:</font>
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		<p style="margin:6pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;color:#000000;">We have examined the Registration Statement on Form&nbsp;S-8&nbsp;(the &#x201C;Registration Statement&#x201D;) to be filed by Pacific Biosciences of California, Inc., a Delaware corporation (the &#x201C;Company&#x201D;), with the Securities and Exchange Commission on or about the date hereof, in connection with the registration under </font><font style="display: inline;">the</font><font style="display: inline;color:#000000;"> Securities Act of 1933, as amended</font><font style="display: inline;color:#000000;">, of </font><font style="display: inline;color:#000000;">3,845,871</font><font style="display: inline;font-size:11pt;">&nbsp;</font><font style="display: inline;">shares of the Company&#x2019;s common stock, </font><font style="display: inline;background-color: #FFFFFF;">par value $0.001 per share</font><font style="display: inline;"> (the &#x201C;Shares&#x201D;), reserved for issuance pursuant to the Company&#x2019;s 2010 Employee Stock Purchase Plan (the &#x201C;2010 ESPP&#x201D;). As the Company&#x2019;s legal counsel, we have reviewed the actions proposed to be taken by the Company in connection with the issuance and sale of the Shares to be issued under the 2010 ESPP.</font>
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			<font style="display: inline;color:#000000;">It is our opinion that the Shares, when issued and sold in the manner referred to in the 2010 ESPP and pursuant to the agreements that accompany the 2010 ESPP, will be legally and validly issued, fully paid and nonassessable.</font>
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		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">We consent to the use of this opinion as an exhibit to the Registration Statement, and further consent to the use of our name wherever appearing in the Registration Statement and any amendments thereto.</font>
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		<p style="margin:0pt 0pt 0pt 234pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 0pt 234pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">Very truly yours,</font>
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		<p style="margin:0pt 0pt 0pt 234pt;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 0pt 234pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">/s/ Wilson Sonsini Goodrich &amp; Rosati</font>
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		<p style="margin:0pt 0pt 0pt 234pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 0pt 234pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">WILSON SONSINI GOODRICH &amp; ROSATI</font>
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		<p style="margin:0pt 0pt 0pt 234pt;border-top:1pt none #D9D9D9 ;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">Professional Corporation</font>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>pacb-20210226xex23_1.htm
<DESCRIPTION>EX-23.1
<TEXT>
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			Exhibit 23.1 EY Consent
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			&nbsp;

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			<font style="display: inline;font-weight:bold;color:#000000;font-size:10pt;">Exhibit 23.1</font>
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			<font style="display: inline;font-weight:bold;color:#000000;font-size:10pt;">&#xFEFF;</font>
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		<p style="margin:0pt;line-height:normal;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:EYInterstate Light;font-weight:bold;color:#000000;font-size:10pt;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</font>
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		<p style="margin:0pt;line-height:normal;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:Tahoma;font-weight:bold;color:#000000;font-size:10pt;">&#xFEFF;</font><font style="display: inline;font-family:Tahoma;color:#000000;font-size:10pt;">&#xFEFF;</font>
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		<p style="margin:0pt;line-height:normal;font-family:Times New Roman;font-size: 10pt">
			<a name="_Hlk64445370"></a><font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Pacific Biosciences of California, Inc. 2010 Employee Stock Purchase Plan of our report dated February </font><font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">26</font><font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">, 2021, with respect to the consolidated financial statements of Pacific Biosciences of California, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission.</font>
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		<p style="margin:0pt;line-height:normal;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">&#xFEFF;</font>
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		<p style="margin:0pt;line-height:normal;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:EYInterstate Light;font-size:10pt;">/s/ Ernst &amp; Young LLP</font>
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		<p style="margin:0pt;line-height:normal;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">&#xFEFF;</font>
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		<p style="margin:0pt;line-height:normal;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">Redwood City, California</font>
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		<p style="margin:0pt;line-height:normal;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">February </font><font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">26</font><font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">, 2021</font>
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		<p style="margin:0pt;background-color: #FFFFFF;line-height:100%;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-size:10pt;">&#xFEFF;</font>
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		<p style="margin:0pt;line-height:100%;font-family:Times New Roman;font-size: 12pt">
			<font style="display: inline;">&#xFEFF;</font>
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