<SEC-DOCUMENT>0001299130-21-000115-index.html : 20210419
<SEC-HEADER>0001299130-21-000115.hdr.sgml : 20210419
<ACCEPTANCE-DATETIME>20210416180828
ACCESSION NUMBER:		0001299130-21-000115
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20210419
DATE AS OF CHANGE:		20210416
EFFECTIVENESS DATE:		20210419

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-255324
		FILM NUMBER:		21832589

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>pacb-20210416xs3.htm
<TEXT>
Document 1 - file: pacb-20210416xs3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>pacb-20210416xs3g001.jpg
<TEXT>
Document 2 - file: pacb-20210416xs3g001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>pacb-20210416xex5_1.htm
<TEXT>
Document 3 - file: pacb-20210416xex5_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>pacb-20210416xex23_1.htm
<TEXT>
Document 4 - file: pacb-20210416xex23_1.htm

</DOCUMENT>
</SEC-DOCUMENT>