<SEC-DOCUMENT>0001299130-21-000115.txt : 20210419
<SEC-HEADER>0001299130-21-000115.hdr.sgml : 20210419
<ACCEPTANCE-DATETIME>20210416180828
ACCESSION NUMBER:		0001299130-21-000115
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20210419
DATE AS OF CHANGE:		20210416
EFFECTIVENESS DATE:		20210419

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-255324
		FILM NUMBER:		21832589

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>pacb-20210416xs3.htm
<TEXT>
<!--HTML document created with Certent Disclosure Management 6.39.3.1-->
<!--Created on: 4/16/2021 4:29:33 PM-->
<html>
	<head>
		<title>
			Form S-3
		</title>
	</head>
	<body><div style="margin-left:36pt;margin-right:36pt;">
		<p style="margin:0pt;line-height:100%;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-weight:bold;">As filed with the Securities and Exchange Commission on </font><font style="display: inline;font-weight:bold;">April 16</font><font style="display: inline;font-weight:bold;">, &nbsp;</font><font style="display: inline;font-weight:bold;">2021</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:right;border-top:1pt none #D9D9D9 ;text-indent:0pt;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-weight:bold;">Registration No. 333-</font><font style="display: inline;font-weight:bold;"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:3pt double #000000 ;border-bottom:1pt none #D9D9D9 ;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 3pt">
			<font style="display: inline;font-size:3pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 14pt">
			<font style="display: inline;font-size:14pt;">UNITED STATES</font><br /><font style="display: inline;font-size:14pt;">SECURITIES AND EXCHANGE COMMISSION</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;">Washington, D.C. 20549</font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 14pt">
			<font style="display: inline;font-weight:bold;font-size:14pt;">FORM S</font><font style="display: inline;font-weight:bold;font-size:14pt;">&#8209;3</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">REGISTRATION STATEMENT</font>
		</p>
		<p style="margin:0pt 0pt 12pt 0.25pt;border-bottom:1pt none #D9D9D9 ;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-style:normal;text-transform:uppercase;">Under</font>
		</p>
		<p style="margin:0pt 0pt 12pt 0.25pt;border-top:1pt none #D9D9D9 ;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-style:normal;text-transform:uppercase;">The Securities Act of 1933</font>
		</p>
		<p style="margin:12pt 0pt 0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 18pt">
			<font style="display: inline;font-weight:bold;font-size:18pt;">Pacific Biosciences of California, Inc.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-bottom:1pt none #D9D9D9 ;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-weight:normal;font-size:9pt;">(Exact name of registrant as specified in its charter)</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 8pt">
			<font style="display: inline;font-weight:normal;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 8pt">
			&nbsp;
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:270.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 9pt">
						<br /><font style="display: inline;">incorporation or organization)</font></p>
				</td>
				<td valign="top" style="width:270.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 9pt">
						<br /><font style="display: inline;">Identification Number)</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:270.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Delaware</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;">(State or other jurisdiction of </font><br /><font style="display: inline;">incorporation or organization)</font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:270.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">16-1590339</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;">(I.R.S. Employer</font><br /><font style="display: inline;">Identification Number)</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:540.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">1305 O&#x2019;Brien Drive</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Menlo Park, California 94025</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">(650) 521-8000</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;">(Address, including zip code, and telephone number, including area code, of registrant&#x2019;s principal executive offices)</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:6pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 6pt">
			<font style="display: inline;font-size:6pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:539.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">&#xFEFF;</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:539.50pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Christian O. Henry</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Chief Executive Officer</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">1305 O&#x2019;Brien Drive</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Menlo Park, California 94025</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">(650) 521-8000</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:6pt 0pt 0pt;line-height:100%;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
			<br /><font style="display: inline;font-style:italic;font-size:6pt;"></font><font style="display: inline;font-weight:bold;font-style:italic;">Copies to:</font>
		</p>
		<p style="margin:0pt;line-height:100%;border-top:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 6pt">
			<font style="display: inline;font-style:italic;font-size:6pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:269.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">&#xFEFF;</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:269.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:269.75pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Donna M. Petkanics, Esq.</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Andrew D. Hoffman, Esq.</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Wilson Sonsini Goodrich &amp; Rosati,</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Professional Corporation</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">650 Page Mill Road</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Palo Alto, CA 94304</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">(650) 493-9300</font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:269.75pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Brett Atkins</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">General Counsel and Corporate Secretary</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Pacific Biosciences of California, Inc.</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">1305 O&#x2019;Brien Drive</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">Menlo Park, California 94025</font></p>
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">(650) 521-8000</font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:539.50pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-weight:bold;">&#xFEFF;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
			<br /><font style="display: inline;font-size:6pt;"></font><br /><font style="display: inline;font-weight:bold;font-size:6pt;"></font><font style="display: inline;font-weight:bold;">From time to time after the effective date of this registration statement.</font><br /><font style="display: inline;font-weight:bold;"></font><font style="display: inline;">(Approximate date of commencement of proposed sale to the public)</font><br /><font style="display: inline;"></font>
		</p>
		<p style="margin:0pt 0pt 6pt;line-height:100%;text-indent:0pt;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: </font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font>
		</p>
		<p style="margin:0pt 0pt 6pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule&nbsp;415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box.</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2612;</font>
		</p>
		<p style="margin:0pt 0pt 6pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">If this Form is filed to register additional securities for an offering pursuant to Rule&nbsp;462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font>
		</p>
		<p style="margin:0pt 0pt 6pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">If this Form is a post-effective amendment filed pursuant to Rule&nbsp;462(c) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font>
		</p>
		<p style="margin:0pt 0pt 6pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule&nbsp;462(e) under the Securities Act, check the following box.</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2612;</font>
		</p>
		<p style="margin:0pt 0pt 6pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule&nbsp;413(b) under the Securities Act, check the following box.</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 9pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;;font-size: 9pt"><font style="display: inline;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#x201C;large accelerated filer,&#x201D; &#x201C;accelerated filer,&#x201D; &#x201C;smaller reporting company&#x201D; and &#x201C;emerging growth company&#x201D; in Rule&nbsp;12b-2 of the Exchange Act.</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-indent:0pt;border-top:1pt none #D9D9D9 ;text-align:left;font-family:Times New Roman;font-size: 6pt">
			<font style="display: inline;font-size:6pt;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:269.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:269.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:269.75pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 35.3pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:3.05pt;"><font style="display: inline;">Large accelerated filer</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font></font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:269.75pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 98.4pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:43pt;"><font style="display: inline;">Accelerated filer </font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font></font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:269.75pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 35.3pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:7.05pt;"><font style="display: inline;">Non-accelerated filer</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2612;</font></font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:269.75pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 98.4pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:9pt;"><font style="display: inline;">Smaller reporting company</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2612;</font></font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:269.75pt;height:12.60pt;padding:0pt 6.5pt">
					<p style="margin:0pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:269.75pt;height:12.60pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 98.4pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:5pt;"><font style="display: inline;">Emerging growth company </font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font></font></p>
				</td>
			</tr>
			<tr>
				<td colspan="2" valign="top" style="border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:539.50pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 0pt 5.5pt;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;"><font style="display: inline;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of Securities Act.</font><font style="display: inline;">&nbsp;</font></font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;"></font><font style="display: inline;font-family:MS Gothic;font-size:10pt;">&#x2610;</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:6pt 0pt 3pt;line-height:100%;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-weight:bold;">CALCULATION OF REGISTRATION FEE</font>
		</p>
		<p style="margin:6pt 0pt 3pt;line-height:100%;text-align:left;border-top:1pt none #D9D9D9 ;text-indent:0pt;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="bottom" style="width:207.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:81.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:88.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:81.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:81.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="border-right:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;width:207.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-size:9pt;">Title of each class of securities to be registered</font></p>
				</td>
				<td valign="bottom" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;width:81.00pt;padding:0pt 5.2pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-size:9pt;">Amount to be registered</font><font style="display: inline;font-size:9pt;font-size:5pt;vertical-align:super;line-height:100%">(1)</font></p>
				</td>
				<td valign="bottom" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;width:88.50pt;padding:0pt 5.2pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-size:9pt;">Proposed maximum offering price per security</font><font style="display: inline;font-size:9pt;font-size:5pt;vertical-align:super;line-height:100%">(2)</font></p>
				</td>
				<td valign="bottom" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;width:81.75pt;padding:0pt 5.2pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-size:9pt;">Proposed maximum aggregate offering price</font><font style="display: inline;font-size:9pt;font-size:5pt;vertical-align:super;line-height:100%">(2)</font></p>
				</td>
				<td valign="bottom" style="border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-top:1pt solid #000000 ;width:81.75pt;padding:0pt 5.2pt;">
					<p style="margin:0pt;line-height:100%;text-align:center;font-weight:bold;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;font-size:9pt;">Amount of registration fee</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt solid #000000 ;border-top:1pt solid #000000 ;border-bottom:2pt double #000000 ;width:207.00pt;height:12.95pt;padding:0pt 5.2pt;">
					<p style="margin:0pt 5.75pt 0pt 4.55pt;line-height:100%;text-indent:0pt;font-family:Times New Roman;font-size: 9pt">
						<font style="display: inline;">Common Stock, par value $0.001 per share</font></p>
				</td>
				<td valign="middle" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-top:1pt solid #000000 ;border-bottom:2pt double #000000 ;width:81.00pt;height:12.95pt;font-family:Times New Roman;font-size:9pt;text-align:right;" nowrap="nowrap">20,689,650&nbsp;
				</td>
				<td valign="bottom" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-top:1pt solid #000000 ;border-bottom:2pt double #000000 ;width:88.50pt;height:12.95pt;font-family:Times New Roman;font-size:9pt;text-align:right;" nowrap="nowrap">$31.035&nbsp;
				</td>
				<td valign="bottom" style="border-right:1pt solid #000000 ;border-left:1pt solid #000000 ;border-top:1pt solid #000000 ;border-bottom:2pt double #000000 ;width:81.75pt;height:12.95pt;font-family:Times New Roman;font-size:9pt;text-align:right;" nowrap="nowrap">$642,103,287.75&nbsp;
				</td>
				<td valign="bottom" style="border-left:1pt solid #000000 ;border-top:1pt solid #000000 ;border-bottom:2pt double #000000 ;width:81.75pt;height:12.95pt;font-family:Times New Roman;font-size:9pt;text-align:right;" nowrap="nowrap">$70,053.47&nbsp;
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt 18pt;border-bottom:1pt none #D9D9D9 ;text-indent:-18pt;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-size:8pt;">(1)</font><font style="display: inline;font-size:8pt;;font-size: 9pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;font-size:8pt;"></font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">Represents the maximum number of shares of</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">&nbsp;</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">common stock, par value </font><font style="display: inline;">$0.001 </font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">per share</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;"> (the &#x201C;Common Stock&#x201D;)</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;"> issuable upon conversion of the</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;"> registrant&#x2019;s</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">&nbsp;</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">1.50% Convertible Senior Notes due 2028 (the &#x201C;Notes&#x201D;)</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">, at a conversion rate corresponding to the initial conversion rate of </font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">22.9885 </font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">shares of </font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">C</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">ommon </font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">S</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">tock per $1,000 principal amount of the Notes</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">. Pursuant to Rule&nbsp;</font><font style="display: inline;font-size:8pt;">416</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">&nbsp;under the&nbsp;</font><font style="display: inline;font-size:8pt;">Securities Act</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;">, the registrant</font><font style="display: inline;color:#000000;font-size:8pt;background-color: #FFFFFF;"> is also registering such indeterminate number of shares of Common Stock as may be issued from time to time upon conversion of the notes as a result of the anti-dilution provisions thereof.</font>
		</p>
		<p style="margin:0pt 0pt 12pt 18pt;border-top:1pt none #D9D9D9 ;text-indent:-18pt;font-family:Times New Roman;font-size: 8pt">
			<font style="display: inline;font-size:8pt;">(2)</font><font style="display: inline;font-size:8pt;;font-size: 8pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;font-size:8pt;"></font><font style="display: inline;font-size:8pt;">Estimated in accordance with Rule 457(c) solely for purposes of calculating the registration fee on the basis of the average of the high and low sale prices of the </font><font style="display: inline;font-size:8pt;">Common Stock</font><font style="display: inline;font-size:8pt;"> of </font><font style="display: inline;font-size:8pt;">the registrant</font><font style="display: inline;font-size:8pt;">&nbsp;</font><font style="display: inline;font-size:8pt;">as reported on The Nasdaq Global Select Market on </font><font style="display: inline;font-size:8pt;">April 12</font><font style="display: inline;font-size:8pt;">, 202</font><font style="display: inline;font-size:8pt;">1</font><font style="display: inline;font-size:8pt;">.</font>
		</p>
		<p style="margin:0pt;border-bottom:3pt double #000000 ;line-height:100%;text-indent:0pt;text-align:left;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 9pt">
			<font style="display: inline;font-weight:bold;font-size:9pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			&nbsp;
		</p></div><div style="margin-left:36pt;margin-right:36pt;">
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;font-weight:bold;text-transform:uppercase;color:#000000;">Prospectus</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;"><img src="pacb-20210416xs3g001.jpg" style="width: 2.229167in; height: 0.78125in" alt="Picture 1"></font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 14pt">
			<font style="display: inline;font-weight:bold;color:#000000;font-size:14pt;">Pacific Biosciences of California, Inc.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">20,689,650 Shares</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;color:#000000;">Common Stock</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			&nbsp;
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">This prospectus relates to the potential sale or disposition from time to time by </font><font style="display: inline;color:#000000;">SB Northstar LP</font><font style="display: inline;"> (the &#x201C;SoftBank&#x201D;) </font><font style="display: inline;">of some or all of the shares of our </font><font style="display: inline;">common stock</font><font style="display: inline;">, par value </font><font style="display: inline;">$0.001 </font><font style="display: inline;">(&#x201C;</font><font style="display: inline;">Common Stock</font><font style="display: inline;">&#x201D;) issuable upon conversion of our </font><font style="display: inline;">1.50% Convertible Senior Notes due 2028</font><font style="display: inline;"> (the &#x201C;Notes&#x201D;)</font><font style="display: inline;">, if any, in any manner described under &#x201C;Plan of Distribution&#x201D; in this prospectus. For purposes of this prospectus, </font><font style="display: inline;">SoftBank</font><font style="display: inline;"> includes its permitted transferees, pledgees, assignees, distributees, donees or successors or others who later hold any of </font><font style="display: inline;">SoftBank&#x2019;s</font><font style="display: inline;"> interests. The Notes were acquired from us in a private placement that closed on </font><font style="display: inline;">February 16, 2021</font><font style="display: inline;"> and is more fully described in the section entitled &#x201C;Prospectus Summary </font><font style="display: inline;">&#x2013;</font><font style="display: inline;">&nbsp;</font><font style="display: inline;">SoftBank</font><font style="display: inline;"> Transaction.&#x201D; We will receive no proceeds from any sale by</font><font style="display: inline;"> SoftBank o</font><font style="display: inline;">f the shares of </font><font style="display: inline;">Common Stock</font><font style="display: inline;"> offered by this prospectus and any prospectus supplement, but in some cases we have agreed to pay certain registration expenses. Please read this prospectus and any applicable prospectus supplement carefully before you invest.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Our </font><font style="display: inline;color:#000000;">common stock</font><font style="display: inline;"> is listed on the Nasdaq Global Select Market (&#x201C;Nasdaq&#x201D;) under the symbol &#x201C;PACB.&#x201D; Each prospectus supplement will indicate whether the securities offered thereby will be listed on any securities exchange. </font><font style="display: inline;">On </font><font style="display: inline;">April </font><font style="display: inline;">15</font><font style="display: inline;">, 202</font><font style="display: inline;">1</font><font style="display: inline;">, the closing sale price of our common stock on </font><font style="display: inline;">Nasdaq</font><font style="display: inline;"> was $</font><font style="display: inline;">32.85</font><font style="display: inline;"> per share.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">Investing in these securities involves risks. Please carefully read the information under the headings &#x201C;Risk Factors&#x201D; beginning on page </font><font style="display: inline;font-weight:bold;">3</font><font style="display: inline;font-weight:bold;"> of this prospectus and &#x201C;Item 1A &#x2013; Risk Factors&#x201D; of our most recent report on Form 10-K or 10-Q that is incorporated by reference in this prospectus before you invest in our securities.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-bottom:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:normal;">The date of this prospectus is</font><font style="display: inline;">&nbsp;</font><font style="display: inline;font-weight:normal;">April 16</font><font style="display: inline;font-weight:normal;">, &nbsp;</font><font style="display: inline;font-weight:normal;">2021</font><font style="display: inline;font-weight:normal;">.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			&nbsp;
		</p></div><div style="margin-left:36pt;margin-right:36pt;">
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;">TABLE OF CONTENTS</font>
		</p>
		<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;text-decoration:underline;">&#xFEFF;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:85.08%;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;width:14.92%;height:1.00pt;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;height:18.45pt;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;height:18.45pt;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;text-decoration:underline;">Page</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#AboutThisProspectus"><font style="display: inline;">ABOUT THIS PROSPECTUS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">ii</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#ProspectusSummary"><font style="display: inline;">PROSPECTUS SUMMARY</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">1</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#TheOffering"><font style="display: inline;">THE OFFERING</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">2</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#RiskFactors"><font style="display: inline;">RISK FACTORS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">3</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#ForwardLookingStmts"><font style="display: inline;">FORWARD-LOOKING STATEMENTS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">4</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#UseofProceeds"><font style="display: inline;">USE OF PROCEEDS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">5</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#DescCapitalStock"><font style="display: inline;">DESCRIPTION OF CAPITAL STOCK</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">5</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#SellingHolders"><font style="display: inline;">SELLING SECURITYHOLDERS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">6</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#PlanofDist"><font style="display: inline;">PLAN OF DISTRIBUTION</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">7</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#LegalMatters"><font style="display: inline;">LEGAL MATTERS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">10</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#Experts"><font style="display: inline;">EXPERTS</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">10</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;width:85.08%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#WhereMoreInfo"><font style="display: inline;">WHERE YOU CAN FIND MORE INFORMATION</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;width:14.92%;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">11</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="border-right:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:85.08%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font><a href="#IncorpRef"><font style="display: inline;">INCORPORATION BY REFERENCE</font></a></p>
				</td>
				<td valign="top" style="border-left:1pt none #D9D9D9 ;border-top:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;width:14.92%;background-color: #CCEEFF;padding:0pt 6.5pt">
					<p style="margin:0pt 54pt 0pt 36pt;text-indent: -36pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">11</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">Neither we nor any selling securityholder or the underwriters, if any, have authorized anyone to provide you with any information or to make any representation other than those contained in or incorporated by reference into this prospectus, any prospectus supplement or in any free writing prospectus that we may file with the Securities and Exchange Commission (the &#x201C;SEC&#x201D;) in connection with this offering. We do not, and any selling securityholder or the underwriters, if any, do not, take any responsibility for, and can provide no assurances as to, the reliability of any information that others may provide you. We are not offering to sell any securities in any jurisdiction where such offer and sale are not permitted. The information contained in or incorporated by reference into this prospectus or any prospectus supplement, free writing prospectus or other offering material is accurate only as of the date of those documents or information, regardless of the time of delivery of the documents or information or the time of any sale of the securities. Neither the delivery of this prospectus or any applicable prospectus supplement nor any distribution of securities pursuant to such documents shall, under any circumstances, create any implication that there has been no change in the information set forth in this prospectus or any applicable prospectus supplement or in our affairs since the date of this prospectus or any applicable prospectus supplement.</font>
		</p>
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		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:259pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:center"><font style="display: inline;"></font></font>
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		</p>
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			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">1</font><font style="font-size:10pt;display: inline;"></font>

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		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

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</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

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</div>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;">ABOUT THIS PR</font><a name="AboutThisProspectus"></a><font style="display: inline;">OSPECTUS</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">This prospectus is part of an &#x201C;automatic shelf&#x201D; registration statement that we filed with the SEC as a &#x201C;well-known seasoned issuer&#x201D; as defined in Rule&nbsp;405&nbsp;of the&nbsp;Securities Act</font><font style="display: inline;color:#000000;"> of 1933</font><font style="display: inline;color:#000000;">, as amended</font><font style="display: inline;color:#000000;">. &nbsp;</font><font style="display: inline;color:#000000;">By using a shelf registration statement, </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> may offer and sell the securities described in this prospectus in one or more offerings or resales.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Information about </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> may change over time. Any changed information given to us by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> will be set forth in a prospectus supplement if and when necessary. Further, in some cases, </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> will also be required to provide a prospectus supplement containing specific information about the terms on which it is offering and selling shares of </font><font style="display: inline;color:#000000;">Common Stock</font><font style="display: inline;color:#000000;">. If a prospectus supplement is provided and the description of the offering in the prospectus supplement varies from the information in this prospectus, you should rely on the information in the prospectus supplement. You should read this prospectus and any prospectus supplement for a specific offering of securities, together with additional information described in the sections entitled &#x201C;Where You Can Find More Information&#x201D; and &#x201C;Information Incorporated by Reference&#x201D; below, before making an investment decision. You should rely only on the information contained in or incorporated by reference into this prospectus, any accompanying prospectus supplement or any free writing prospectus prepared by or on behalf of us to which we have referred you. If there is any inconsistency between this prospectus and the information contained in a prospectus supplement or any free writing prospectus, you should rely on the information in the prospectus supplement or such free writing prospectus prepared by or on behalf of us to which we have referred you.</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">This prospectus (as supplemented and amended) does not constitute an offer to sell or the solicitation of an offer to buy any securities other than the securities described in this prospectus or an offer to sell or the solicitation of an offer to buy any such securities in any circumstances in which such offer or solicitation is unlawful. This document may only be used where it is legal to sell these securities. You should not assume that the information contained in this prospectus (as supplemented and amended) is accurate as of any dates other than their respective dates.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">We urge you to read carefully this prospectus (as supplemented and amended) before deciding whether to purchase any of our securities being offered.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Unless we state otherwise or the context otherwise requires, references to &#x201C;Pacific Biosciences,&#x201D; &#x201C;PacBio,&#x201D; the &#x201C;Company,&#x201D; &#x201C;us,&#x201D; &#x201C;we&#x201D; or &#x201C;our&#x201D; in this prospectus mean Pacific Biosciences of California, Inc.</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">and its consolidated subsidiaries. When we refer to &#x201C;you&#x201D; in this section, we mean all purchasers of the securities being offered by this prospectus and any accompanying prospectus supplement, whether they are the holders or only indirect owners of those securities.</font>
		</p></div><div style="margin-left:50pt;margin-right:50pt;">
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		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">2</font><font style="font-size:10pt;display: inline;"></font>

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		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

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</div>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;">PROSPECT</font><a name="ProspectusSummary"></a><font style="display: inline;">US SUMMARY</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:36pt;border-bottom:1pt none #D9D9D9 ;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:normal;font-style:italic;">This summary highlights selected information that is presented in greater detail elsewhere, or incorporated by reference, in this prospectus. It does not contain all of the information that may be important to you and your investment decision. Before investing in our securities, you should carefully read this entire prospectus, including the matters set forth under the section of this prospectus captioned &#x201C;Risk Factors&#x201D; and the financial statements and related notes and other information that we incorporate by reference herein, including our Annual Report on Form 10-K and our Quarterly Reports on Form 10-Q. Unless the context indicates otherwise, references in this prospectus to &#x201C;Pacific Biosciences,&#x201D; &#x201C;PacBio,&#x201D; &#x201C;we,&#x201D; &#x201C;our&#x201D; and &#x201C;us&#x201D; refer, collectively, to Pacific Biosciences of California, Inc., a Delaware corporation, and its subsidiaries taken as a whole.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Company Overview</font>
		</p>
		<p style="margin:0pt;line-height:normal;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">We design, develop and manufacture sequencing systems to help scientists resolve genetically complex problems. Based on our novel Single Molecule, Real-Time (SMRT&#xAE;) sequencing technology, our products enable: de novo genome assembly to finish genomes in order to more fully identify, annotate and decipher genomic structures; full-length transcript analysis to improve annotations in reference genomes, characterize alternatively spliced isoforms in important gene families, and find novel genes; targeted sequencing to more comprehensively characterize genetic variations; and real-time kinetic information for epigenome characterization. Our technology provides high accuracy, ultra-long reads, uniform coverage and the ability to simultaneously detect epigenetic changes. PacBio&#xAE; sequencing systems, including consumables and software, provide a simple and fast end-to-end workflow for SMRT sequencing. </font>
		</p>
		<p style="margin:0pt;line-height:normal;text-indent:24.5pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">&#xFEFF;</font>
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			<font style="display: inline;color:#000000;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 12pt;font-weight:bold;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Corporate Information</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Pacific Biosciences of California, Inc., formerly Nanofluidics, Inc. was incorporated in the State of Delaware in 2000. Our executive offices are located at 1305 O&#x2019;Brien Drive, Menlo Park, California 94025, and our telephone number is&nbsp;(650) 521-8000.&nbsp;We maintain a website at </font><font style="display: inline;font-style:italic;color:#000000;">www.pacb.com</font><font style="display: inline;color:#000000;"> where general information about us is available. Our website, and the information contained therein, is not a part of this prospectus.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:24.5pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 12pt;font-weight:bold;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">SoftBank Transaction</font>
		</p>
		<p style="margin:6pt 0pt 0pt;background-color: #FFFFFF;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">On </font><font style="display: inline;color:#000000;">February 9, 2021</font><font style="display: inline;color:#000000;">, we entered into an investment agreement (the &#x201C;Investment Agreement&#x201D;) with </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> relating to the issuance and sale to </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> of $</font><font style="display: inline;color:#000000;">900,000,000 in aggregate principal amount of </font><font style="display: inline;color:#000000;">our</font><font style="display: inline;color:#000000;"> 1.50% Convertible Senior Notes due 2028</font><font style="display: inline;color:#000000;">. The transactions contemplated by the Investment Agreement closed on </font><font style="display: inline;color:#000000;">February 16, 2021</font><font style="display: inline;color:#000000;">. In connection with the issuance of the </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes, on </font><font style="display: inline;color:#000000;">February 16, 2021</font><font style="display: inline;color:#000000;">, we entered into an indenture (the &#x201C;Indenture&#x201D;) with U.S. Bank National Association, as trustee. The </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes are convertible at the option of the holder at any time until the scheduled trading day prior to the maturity date, including in connection with a redemption by us. The </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes </font><font style="display: inline;color:#000000;">are</font><font style="display: inline;color:#000000;"> convertible into shares of our common stock based on an initial conversion rate of </font><font style="display: inline;color:#000000;">22.9885 shares of common stock per $1,000 principal amount of the Notes</font><font style="display: inline;color:#000000;"> (which is equal to an initial conversion price of </font><font style="display: inline;color:#000000;">$43.50 per </font><font style="display: inline;color:#000000;">share), </font><font style="display: inline;color:#000000;">in each case subject to customary anti-dilution and other adjustments as a result of certain extraordinary transactions.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:36pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">We sold the </font><font style="display: inline;color:#000000;">Notes</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">in a transaction exempt from the registration requirements of the&nbsp;Securities Act, and expect to rely on an exemption for any issuance of the shares of common stock issuable upon conversion of the </font><font style="display: inline;color:#000000;">Notes</font><font style="display: inline;color:#000000;">.</font>
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		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

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			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">1</font><font style="font-size:10pt;display: inline;"></font>

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			&nbsp;

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			&nbsp;

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</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;color:#000000;"></font>
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		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">THE OFFER</font><a name="TheOffering"></a><font style="display: inline;">ING</font>
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					<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Common stock offered</font><font style="display: inline;"> by the selling </font><font style="display: inline;">securityholders</font></p>
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				<td valign="top" style="width:255.35pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt 6.5pt">
					<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">SoftBank</font><font style="display: inline;"> may offer and sell some or all of the 20,689,650</font><font style="display: inline;">&nbsp;</font><font style="display: inline;">shares of our </font><font style="display: inline;">C</font><font style="display: inline;">ommon </font><font style="display: inline;">S</font><font style="display: inline;">tock that may be issued upon conversion of the </font><font style="display: inline;">N</font><font style="display: inline;">otes in any manner described under &#x201C;Plan of Distribution&#x201D; in this prospectus. Throughout this prospectus, when we refer to the shares of our common stock being registered on behalf of </font><font style="display: inline;">SoftBank</font><font style="display: inline;">, we are referring to the shares of Common Stock that may be issued upon conversion of the </font><font style="display: inline;">N</font><font style="display: inline;">otes.</font></p>
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					<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Use of proceeds</font></p>
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						<font style="display: inline;">SoftBank </font><font style="display: inline;">will receive all of the proceeds from the sale under this prospectus of the notes and the shares of Common Stock issuable upon conversion of the </font><font style="display: inline;">N</font><font style="display: inline;">otes, if any. We will not receive any proceeds from these sales.</font></p>
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					<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Listing</font></p>
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					<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Our Common Stock is listed on </font><font style="display: inline;">t</font><font style="display: inline;">he Nasdaq Global Select Market under the symbol </font><font style="display: inline;">&#x201C;</font><font style="display: inline;">PACB</font><font style="display: inline;">.&#x201D;</font></p>
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			<font style="display: inline;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 12pt;text-indent:36pt;text-align:left;border-top:1pt solid #000000 ;border-left:1pt solid #000000 ;border-bottom:1pt solid #000000 ;border-right:1pt solid #000000 ;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			&nbsp;
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			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">2</font><font style="font-size:10pt;display: inline;"></font>

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			&nbsp;

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		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;color:#000000;">&#xFEFF;</font>
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		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">RISK FAC</font><a name="RiskFactors"></a><font style="display: inline;">TORS</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">An investment in our securities involves a high degree of risk. The prospectus supplement applicable to each offering of our securities will contain a discussion of the risks applicable to an investment in our securities. Prior to making a decision about investing in our securities, you should carefully consider the specific factors discussed under the section in the applicable prospectus supplement captioned &#x201C;Risk Factors,&#x201D; together with all of the other information contained or incorporated by reference in the prospectus supplement or appearing or incorporated by reference in this prospectus. You should also consider the risks, uncertainties and assumptions discussed under &#x201C;Part&nbsp;I&#x2014;Item&nbsp;1A&#x2014;Risk Factors&#x201D; of our most recent Annual Report on Form&nbsp;10-K and in &#x201C;Part&nbsp;II&#x2014;Item&nbsp;1A&#x2014;Risk Factors&#x201D; in our most recent Quarterly Report on Form&nbsp;10-Q filed subsequent to such Form 10-K that are incorporated herein by reference, as may be amended, supplemented or superseded from time to time by other reports we file with the SEC in the future. The risks and uncertainties we have described are not the only ones we face. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our operations.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">3</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">FORWARD-LOOKI</font><a name="ForwardLookingStmts"></a><font style="display: inline;">NG STATEMENTS</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">This prospectus, each prospectus supplement and the information incorporated by reference in this prospectus and each prospectus supplement contain certain statements that constitute &#x201C;forward-looking statements&#x201D; within the meaning of Section&nbsp;27A of the Securities Act of 1933, as amended, or the Securities Act, and Section&nbsp;21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. The words &#x201C;believe,&#x201D; &#x201C;may,&#x201D; &#x201C;will,&#x201D; &#x201C;estimate,&#x201D; &#x201C;continue,&#x201D; &#x201C;anticipate,&#x201D; &#x201C;intend,&#x201D; &#x201C;expect,&#x201D; &#x201C;could,&#x201D; &#x201C;would,&#x201D; &#x201C;project,&#x201D; &#x201C;plan,&#x201D; &#x201C;potentially,&#x201D; &#x201C;likely,&#x201D; and similar expressions and variations thereof are intended to identify forward-looking statements, but are not the exclusive means of identifying such statements. Those statements appear in this prospectus, any accompanying prospectus supplement and the documents incorporated herein and therein by reference, particularly in the sections captioned &#x201C;Risk Factors&#x201D; and &#x201C;Management&#x2019;s Discussion and Analysis of Financial Condition and Results of Operations&#x201D; and include statements regarding the intent, belief or current expectations of our management that are subject to known and unknown risks, uncertainties and assumptions. You are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, and that actual results may differ materially from those projected in the forward-looking statements as a result of various factors.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified, you should not rely upon forward-looking statements as predictions of future events. The events and circumstances reflected in the forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Except as required by applicable law, including the securities laws of the United States and the rules and regulations of the SEC, we do not plan to publicly update or revise any forward-looking statements contained herein after we distribute this prospectus, whether as a result of any new information, future events or otherwise.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">In addition, statements that &#x201C;we believe&#x201D; and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this prospectus, and although we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted a thorough inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain and investors are cautioned not to unduly rely upon these statements.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">This prospectus and the documents incorporated by reference in this prospectus may contain market data that we obtain from industry sources. These sources do not guarantee the accuracy or completeness of the information. Although we believe that our industry sources are reliable, we do not independently verify the information. The market data may include projections that are based on a number of other projections. While we believe these assumptions to be reasonable and sound as of the date of this prospectus, actual results may differ from the projections.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">4</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">USE OF PR</font><a name="UseofProceeds"></a><font style="display: inline;">OCEEDS</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:18pt;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;font-size:10pt;">SoftBank will receive all of the proceeds from the sale of the shares of common stock issuable upon conversion of the notes, if any. We will not receive any proceeds from these sales.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:18pt;border-top:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 12pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">DESCRIPTION OF </font><a name="DescCapitalStock"></a><font style="display: inline;">CAPITAL STOCK</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">The description of our capital stock is incorporated by reference to Exhibit&nbsp;4</font><font style="display: inline;">.2</font><font style="display: inline;"> to our Annual Report on Form&nbsp;10</font><font style="display: inline;">&#8209;K for the fiscal year ended </font><font style="display: inline;">December 31</font><font style="display: inline;color:#000000;">, 20</font><font style="display: inline;color:#000000;">20</font><font style="display: inline;">, filed with the SEC on </font><font style="display: inline;">February 26</font><font style="display: inline;color:#000000;">, 20</font><font style="display: inline;color:#000000;">21</font><font style="display: inline;color:#000000;">.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">5</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;font-weight:bold;color:#000000;"></font>
		</p>
		<p style="margin:0pt;background-color: #FFFFFF;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;color:#000000;">SELLING SECURI</font><a name="SellingHolders"></a><font style="display: inline;font-weight:bold;color:#000000;">TYHOLDERS</font>
		</p>
		<p style="margin:6pt 0pt 0pt;background-color: #FFFFFF;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">On </font><font style="display: inline;color:#000000;">February 16, 2021</font><font style="display: inline;color:#000000;">, we issued $</font><font style="display: inline;color:#000000;">900,000,000</font><font style="display: inline;color:#000000;"> aggregate principal amount of the </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes to </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">, pursuant to the </font><font style="display: inline;color:#000000;">Investment Agreement</font><font style="display: inline;color:#000000;">. The </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes were initially convertible into an aggregate of </font><font style="display: inline;color:#000000;">20,689,650 </font><font style="display: inline;color:#000000;">shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">and were issued in transactions exempt from the registration requirements of the&nbsp;Securities Act. With certain exceptions, </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> is subject to certain transfer restrictions pursuant to the </font><font style="display: inline;color:#000000;">Investment Agreement </font><font style="display: inline;color:#000000;">that contractually prohibit the transfer or any sale of the shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">issuable upon conversion of the </font><font style="display: inline;color:#000000;">No</font><font style="display: inline;color:#000000;">tes by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">to a&nbsp;non-affiliated&nbsp;third-party until the earliest of (i) March 12, 2022 and (ii) a </font><font style="display: inline;color:#000000;">C</font><font style="display: inline;color:#000000;">hange in </font><font style="display: inline;color:#000000;">C</font><font style="display: inline;color:#000000;">ontrol (as defined in the </font><font style="display: inline;color:#000000;">Investment Agreement</font><font style="display: inline;color:#000000;">) of us.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">For purposes of this prospectus, </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">includes its permitted transferees, pledgees, assignees, distributees, donees or successors or others who later hold any of </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">interests. Our registration of the shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">issuable upon conversion of the </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes does not necessarily mean that </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">will sell all or any of such shares of </font><font style="display: inline;color:#000000;">Common Stock</font><font style="display: inline;color:#000000;">. The following table sets forth certain information as of </font><font style="display: inline;color:#000000;">March </font><font style="display: inline;color:#000000;">31,</font><font style="display: inline;color:#000000;"> 2021</font><font style="display: inline;color:#000000;"> concerning the shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">that may be offered from time to time by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> with this prospectus. The information is based on information provided by or on behalf of </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">. In the table below, the number of shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">that may be offered pursuant to this prospectus is calculated based on the conversion rate, as of the date of this prospectus, of </font><font style="display: inline;color:#000000;">22.9885</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">per $1,000 aggregate principal amount of notes. The number of shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">issuable upon conversion of the </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes is subject to adjustment under certain circumstances described in the </font><font style="display: inline;color:#000000;">I</font><font style="display: inline;color:#000000;">ndenture governing the </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes. Accordingly, the number of shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">issuable upon conversion of the </font><font style="display: inline;color:#000000;">N</font><font style="display: inline;color:#000000;">otes and the number of shares of </font><font style="display: inline;color:#000000;">Common Stock </font><font style="display: inline;color:#000000;">beneficially owned and offered by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">pursuant to this prospectus may increase or decrease from that set forth in the table below. Information about </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">may change over time. Any changed or new information given to us by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">will be set forth in supplements to this prospectus or amendments to the registration statement of which this prospectus is a part, if and when necessary.</font>
		</p>
		<p style="margin:0pt;background-color: #FFFFFF;text-indent:0pt;font-family:Times New Roman;font-size: 12pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" align="center" style="border-collapse:collapse;background-color: #FFFFFF;margin-left:0pt;">
			<tr>
				<td valign="bottom" style="width:52.98%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:00.72%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
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				<td valign="bottom" style="width:01.66%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:09.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:00.52%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:00.52%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:10.24%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:01.80%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:12.60%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:00.20%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:09.76%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:5.75pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:5.75pt;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:52.98%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;text-indent:0pt;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">Name</font></p>
				</td>
				<td valign="bottom" style="width:00.72%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:10.66%;border-bottom:1pt solid #000000 ;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">Number of</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Shares of</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Common</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Stock</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Beneficially</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Owned and</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Offered</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Hereby&nbsp;</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">(1)</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">(2)</font></p>
				</td>
				<td valign="bottom" style="width:00.52%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:10.76%;border-bottom:1pt solid #000000 ;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">Percentage</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">of</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Shares of</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Common</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Stock</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Beneficially</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Owned and</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Offered</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Hereby&nbsp;</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">(</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">3</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">)</font></p>
				</td>
				<td valign="bottom" style="width:01.80%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:12.60%;border-bottom:1pt solid #000000 ;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">Shares</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Beneficially</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Owned</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">After the</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Offering</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">(</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">4</font><font style="display: inline;font-weight:bold;font-size:7pt;font-size:4pt;vertical-align:super;line-height:100%">)</font></p>
				</td>
				<td valign="top" style="width:00.20%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:09.76%;border-bottom:1pt solid #000000 ;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">Percentage</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">of</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Shares of</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Common</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Stock</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Beneficially</font><br /><font style="display: inline;font-weight:bold;font-size:8pt;">Owned </font><font style="display: inline;font-weight:bold;font-size:8pt;">After the Offering</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:52.98%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0pt 12pt;text-indent: -12pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;color:#000000;">SB Northstar LP</font></p>
				</td>
				<td valign="bottom" style="width:00.72%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:01.66%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:09.00%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">30,550,739</font></p>
				</td>
				<td valign="bottom" style="width:00.52%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:00.52%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&nbsp;</font></p>
				</td>
				<td valign="bottom" style="width:10.24%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">13.9</font><font style="display: inline;">%</font></p>
				</td>
				<td valign="bottom" style="width:01.80%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:12.60%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">9,861,089</font></p>
				</td>
				<td valign="bottom" style="width:00.20%;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:09.76%;border-top:1pt solid #000000 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">4.5</font><font style="display: inline;">%</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;background-color: #FFFFFF;text-indent:0pt;font-family:Times New Roman;font-size: 6pt">
			<font style="display: inline;">&nbsp;</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;background-color: #FFFFFF;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:04.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:490.75pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #FFFFFF;height:1.00pt;padding:0pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:04.00%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">(1)</font></p>
				</td>
				<td valign="top" style="width:490.75pt;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Assumes for each $1,000 in principal amount of the </font><font style="display: inline;">N</font><font style="display: inline;">otes a conversion rate, as of the date of this prospectus, of </font><font style="display: inline;color:#000000;">22.9885</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;">shares of Common Stock upon conversion and full physical settlement. This conversion rate is subject to adjustment, however, as described in this prospectus under &#x201C;Description of Notes&#x2014;Conversion Rights&#x2014;Adjustment to Conversion Rate.&#x201D; As a result, the number of shares of Common Stock issuable upon conversion of the </font><font style="display: inline;">N</font><font style="display: inline;">otes may increase or decrease in the future.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:04.00%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">(2)</font></p>
				</td>
				<td valign="top" style="width:490.75pt;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Consists of 20,689,650 shares issuable upon conversion of the Notes and 9,861,089 shares as of March 31, 2021, in each case beneficially owned by SB Northstar LP, which is an indirect subsidiary of SoftBank Group Corporation. The principal business address of SB Northstar LP is 190 Elgin Avenue, George Town, Grand Cayman KY1-9008, Cayman Islands. The principal business address of SoftBank Group Corporation is 1-9-1, Higashi-Shimbashi Minato-ku, Tokyo 105-7303 Japan.</font><font style="display: inline;">&nbsp;</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:04.00%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">(</font><font style="display: inline;">3</font><font style="display: inline;">)</font></p>
				</td>
				<td valign="top" style="width:490.75pt;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">The percentage reflects the </font><font style="display: inline;">198,339,724</font><font style="display: inline;">&nbsp;</font><font style="display: inline;">shares of Common Stock outstanding as of </font><font style="display: inline;">March 31,</font><font style="display: inline;"> 2021</font><font style="display: inline;"> and gives effect to the total number of shares of Common Stock beneficially owned and offered hereby by </font><font style="display: inline;">SoftBank</font><font style="display: inline;">, assuming full physical settlement.</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:04.00%;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">(</font><font style="display: inline;">4</font><font style="display: inline;">)</font></p>
				</td>
				<td valign="top" style="width:490.75pt;background-color: #FFFFFF;padding:0pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">The table assumes that </font><font style="display: inline;">SoftBank</font><font style="display: inline;"> sells all of its shares offered pursuant to this prospectus. We are unable to determine the number of shares that will actually be sold pursuant to this prospectus.</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:12pt 0pt 0pt;background-color: #FFFFFF;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Except for the transactions referred to herein and in documents filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the&nbsp;Exchange Act&nbsp;(including the investment agreement and documents related to director positions with the Company), </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> does not have, and within the last three years has not had, any position, office or other material relationship (legal or otherwise) with us or any of our subsidiaries other than as a holder of our securities.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">6</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">PLAN OF DIST</font><a name="PlanofDist"></a><font style="display: inline;">RIBUTION</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;">, including its pledgees, donees, transferees, distributees, beneficiaries or other successors in interest, may from time to time offer some or all of the shares of </font><font style="display: inline;">Common Stock</font><font style="display: inline;"> (collectively, &#x201C;Securities&#x201D;) covered by this prospectus. To the extent required, this prospectus may be amended and supplemented from time to time to describe a specific plan of distribution.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;"> will not pay any of the costs, expenses and fees incurred in connection with the registration and sale of the Securities covered by this prospectus, but it will pay any and all underwriting discounts, selling commissions and stock transfer taxes, if any, attributable to sales of the Securities. We will not receive any proceeds from the sale of the shares of </font><font style="display: inline;">Common Stock</font><font style="display: inline;"> covered hereby.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;"> may sell the Securities covered by this prospectus, as it may be amended and supplemented, from time to time, and may also decide not to sell all or any of the Securities that it is allowed to sell under this prospectus. </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;"> will act independently of us in making decisions regarding the timing, manner and size of each sale. These dispositions may be at fixed prices, at market prices prevailing at the time of sale, at prices related to such prevailing market prices, at varying prices determined at the time of sale, or at privately negotiated prices. Sales may be made by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;"> in one or more types of transactions, which may include:</font>
		</p>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">purchases by underwriters, dealers and agents who may receive compensation in the form of underwriting discounts, concessions or commissions from </font><font style="display: inline;color:#000000;">SoftBank </font><font style="display: inline;color:#000000;">and/or the purchasers of the Securities for whom they may act as agent;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">one or more block transactions, including transactions in which the broker or dealer so engaged will attempt to sell the Securities as agent but may position and resell a portion of the block as principal to facilitate the transaction, or in crosses, in which the same broker acts as an agent on both sides of the trade;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">ordinary brokerage transactions or transactions in which a broker solicits purchases;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">purchases by a broker-dealer or market maker, as principal, and resale by the broker-dealer for its account;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">the pledge of Securities for any loan or obligation, including pledges to brokers or dealers who may from time to time effect distributions of shares of our Common Stock and, in the case of any collateral call or default on such loan or obligation, pledges or sales of shares of our Common Stock by such pledgees or secured parties;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">short sales or transactions to cover short sales relating to the Securities;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">one or more exchanges or over the counter market transactions;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">through distribution by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> or its successor in interest to its members, general or limited partners or shareholders (or their respective members, general or limited partners or shareholders);</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">privately negotiated transactions;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">the writing of options, whether the options are listed on an options exchange or otherwise;</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">distributions to creditors and equity holders of </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">; and</font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;border-top:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt;">
			<font style="display: inline;color:#000000;">any combination of the foregoing, or any other available means allowable under applicable law.</font></p></td></tr></table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">may also resell all or a portion of its Securities in open market transactions in reliance upon Rule 144 under the Securities Act provided it meets the criteria and conforms to the requirements of Rule 144 and all applicable laws and regulations.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;">may enter into sale, forward sale and derivative transactions with third parties, or may sell securities not covered by this prospectus, including the notes, to third parties in privately negotiated transactions. </font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">In connection with those sale, forward sale or derivative transactions, the third parties (or underwriters on their behalf) may sell shares of our Common Stock, including in short sale transactions and by issuing securities that are not covered by this prospectus but are exchangeable for or represent beneficial interests in our Common Stock. The third parties also may use shares received under those sale, forward sale or derivative arrangements or shares pledged by </font><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;color:#000000;"> or borrowed from </font>
		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">7</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;font-family:Times New Roman;font-size: 10pt"><font style="display: inline;color:#000000;">SoftBank</font><font style="display: inline;"> or others to settle such third-party sales or to close out any related open borrowings of our Common Stock. The third parties or underwriters selling shares of our Common Stock on their behalf may deliver this prospectus in connection with any such transactions. Any third party in such sale transactions will be an underwriter and will be identified in a supplement or a post-effective amendment to the registration statement of which this prospectus is a part as may be required.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">In addition, SoftBank may engage in hedging transactions with broker-dealers in connection with distributions of Securities or otherwise. In those transactions, broker-dealers may engage in short sales of securities in the course of hedging the positions they assume with SoftBank. SoftBank may also sell securities short and redeliver securities to close out such short positions. SoftBank may also enter into option or other transactions with broker-dealers which require the delivery of securities to the broker-dealer. The broker-dealer may then resell or otherwise transfer such securities pursuant to this prospectus. SoftBank also may loan or pledge shares, and the borrower or pledgee may sell or otherwise transfer the Securities so loaned or pledged pursuant to this prospectus. Such borrower or pledgee also may transfer those Securities to investors in our securities or SoftBank&#x2019;s securities or in connection with the offering of other securities not covered by this prospectus.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">To the extent necessary, the specific terms of the offering of the Securities, including the specific Securities to be sold, the name of SoftBank, the respective purchase prices and public offering prices, the names of any underwriter, broker-dealer or agent, if any, and any applicable compensation in the form of discounts, concessions or commissions paid to underwriters or agents or paid or allowed to dealers will be set forth in a supplement to this prospectus or a post-effective amendment to this registration statement of which this prospectus forms a part. SoftBank may, or may authorize underwriters, dealers and agents to, solicit offers from specified institutions to purchase Securities from SoftBank at the public offering price listed in the applicable prospectus supplement. These sales may be made under &#x201C;delayed delivery contracts&#x201D; or other purchase contracts that provide for payment and delivery on a specified future date. If necessary, any such contracts will be described in, and be subject to the conditions set forth in, a supplement to this prospectus or a post-effective amendment to this registration statement of which this prospectus forms a part.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Broker-dealers or agents may receive compensation in the form of commissions, discounts or concessions from SoftBank. Broker-dealers or agents may also receive compensation from the purchasers of Securities for whom they act as agents or to whom they sell as principals, or both. Compensation to a particular broker-dealer might be in excess of customary commissions and will be in amounts to be negotiated in connection with transactions involving securities. In effecting sales, broker-dealers engaged by SoftBank may arrange for other broker-dealers to participate in the resales.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">In connection with sales of Securities covered hereby, SoftBank and any underwriter, broker-dealer or agent and any other participating broker-dealer that executes sales for SoftBank may be deemed to be an &#x201C;underwriter&#x201D; within the meaning of the Securities Act. Accordingly, any profits realized by SoftBank and any compensation earned by such underwriter, broker-dealer or agent may be deemed to be underwriting discounts and commissions. Selling securityholders who are an &#x201C;underwriters&#x201D; under the Securities Act must deliver this prospectus in the manner required by the Securities Act. This prospectus delivery requirement may be satisfied through the facilities of the Nasdaq Stock Market in accordance with Rule 153 under the Securities Act or satisfied in accordance with Rule 174 under the Securities Act.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">We and SoftBank have agreed to indemnify each other against certain liabilities, including liabilities under the Securities Act. In addition, we or SoftBank may agree to indemnify any underwriters, broker-dealers and agents against or contribute to any payments the underwriters, broker-dealers or agents may be required to make with respect to, civil liabilities, including liabilities under the Securities Act. Underwriters, broker-dealers and agents and their affiliates are permitted to be customers of, engage in transactions with, or perform services for us and our affiliates or SoftBank or their affiliates in the ordinary course of business.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">SoftBank will be subject to the applicable provisions of Regulation M of the Exchange Act and the rules and regulations thereunder, which provisions may limit the timing of purchases and sales of any of the Securities by SoftBank. Regulation M may also restrict the ability of any person engaged in the distribution of the Securities to engage in market-making activities with respect to the Securities. These restrictions may affect the marketability of such Securities.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">In order to comply with applicable securities laws of some states or countries, the Securities may only be sold in those jurisdictions through registered or licensed brokers or dealers and in compliance with applicable laws and regulations. In addition, in certain states or countries the Securities may not be sold unless they have been registered or qualified for sale in the applicable state or country or an exemption from the registration or qualification requirements is available. In addition, any Securities of a selling securityholder covered by this prospectus that qualify for sale pursuant to Rule 144 under the Securities Act may be sold in open market transactions under Rule 144 rather than pursuant to this prospectus.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">In connection with an offering of Securities under this prospectus, the underwriters may purchase and sell securities in the open market. These transactions may include short sales, stabilizing transactions and purchases to cover positions created by short sales. Short sales involve the sale by the underwriters of a greater number of securities than they are required to purchase </font>
		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">8</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;font-family:Times New Roman;font-size: 10pt"><font style="display: inline;">in an offering. Stabilizing transactions consist of certain bids or purchases made for the purpose of preventing or retarding a decline in the market price of the securities while an offering is in progress.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">The underwriters also may impose a penalty bid. This occurs when a particular underwriter repays to the underwriters a portion of the underwriting discount received by it because the underwriters have repurchased securities sold by or for the account of that underwriter in stabilizing or short-covering transactions.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">These activities by the underwriters may stabilize, maintain or otherwise affect the market price of the Securities offered under this prospectus. As a result, the price of the Securities may be higher than the price that otherwise might exist in the open market. If these activities are commenced, they may be discontinued by the underwriters at any time. These transactions may be effected on the Nasdaq Stock Market or another securities exchange or automated quotation system, or in the over-the-counter market or otherwise.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">9</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">LEGAL </font><a name="LegalMatters"></a><font style="display: inline;">MATTERS</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">The validity of the securities offered hereby will be passed upon for us by Wilson Sonsini Goodrich&nbsp;&amp; Rosati, Professional Corporation, Palo Alto, California. Additional legal matters may be passed on for us, or any underwriters, dealers or agents by counsel we will name in the applicable prospectus supplement.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">EXPE</font><a name="Experts"></a><font style="display: inline;">RTS</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">The financial statements incorporated in this Prospectus by reference to the Annual Report on Form 10-K for the year ended December 31, 2020 have been so incorporated in reliance on the report of Ernst &amp; Young LLP, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">10</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">WHERE YOU CAN F</font><a name="WhereMoreInfo"></a><font style="display: inline;">IND MORE INFORMATION</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">We file annual, quarterly and current reports, proxy statements and other information with the SEC. Our SEC filings are available to the public over the Internet at the SEC&#x2019;s website at </font><font style="display: inline;font-style:italic;">www.sec.gov</font><font style="display: inline;">. Copies of certain information filed by us with the SEC are also available on our website at </font><font style="display: inline;font-style:italic;">https://www.pacb.com/</font><font style="display: inline;">. Information accessible on or through our website is not a part of this prospectus.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">This prospectus and any prospectus supplement is part of a registration statement that we filed with the SEC and do not contain all of the information in the registration statement. You should review the information and exhibits in the registration statement for further information on us and our consolidated subsidiaries and the securities that we are offering. Forms of any documents establishing the terms of the offered securities are filed as exhibits to the registration statement of which this prospectus forms a part or under cover of a Current Report on Form 8-K and incorporated in this prospectus by reference. Statements in this prospectus or any prospectus supplement about these documents are summaries and each statement is qualified in all respects by reference to the document to which it refers. You should read the actual documents for a more complete description of the relevant matters.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">INCORPORATIO</font><a name="IncorpRef"></a><font style="display: inline;">N BY REFERENCE</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">The SEC allows us to incorporate by reference much of the information that we file with the SEC, which means that we can disclose important information to you by referring you to those publicly available documents. The information that we incorporate by reference in this prospectus is considered to be part of this prospectus. Because we are incorporating by reference future filings with the SEC, this prospectus is continually updated and those future filings may modify or supersede some of the information included or incorporated by reference in this prospectus. This means that you must look at all of the SEC filings that we incorporate by reference to determine if any of the statements in this prospectus or in any document previously incorporated by reference have been modified or superseded. This prospectus incorporates by reference the documents listed below and any future filings we make with the SEC under Sections&nbsp;13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than those documents or the portions of those documents furnished pursuant to Items 2.02 or 7.01 of any Current Report on Form&nbsp;8-K and, except as may be noted in any such Form&nbsp;8-K, exhibits filed on such form that are related to such information), until the offering of the securities under the registration statement of which this prospectus forms a part is terminated or completed:</font>
		</p>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;color:#000000;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
			<font style="display: inline;color:#000000;">our Annual Report on Form 10-K for the year ended December 31, 2020; </font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;color:#000000;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
			<font style="display: inline;color:#000000;">the portions of our Definitive Proxy Statement on Schedule&nbsp;14A (other than information furnished rather than filed) that are incorporated by reference into our Annual Report on Form&nbsp;10</font><font style="display: inline;color:#000000;">&#8209;K</font><font style="display: inline;color:#000000;"> for the fiscal year ended December 31, 2019</font><font style="display: inline;color:#000000;">, filed with the SEC on April 28, 2020; </font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;color:#000000;border-top:1pt none #D9D9D9;border-bottom:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
			<font style="display: inline;color:#000000;">our Current Reports on Form 8-K filed on January 8, 2021</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;background-color: #FFFFFF;">(other than information furnished rather than filed)</font><font style="display: inline;color:#000000;">, January 13, 2021</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;background-color: #FFFFFF;">(other than information furnished rather than filed)</font><font style="display: inline;color:#000000;">, February 9, 2021, February 10, 2021</font><font style="display: inline;color:#000000;">&nbsp;</font><font style="display: inline;color:#000000;background-color: #FFFFFF;">(other than information furnished rather than filed)</font><font style="display: inline;color:#000000;"> and February 17, 2021; and </font></p></td></tr></table></div>
		<div style="width:100%"><table style="width:100%; table-layout: fixed;" cellpadding="0" cellspacing="0"><tr><td style="width:36pt;"><p style="width:36pt;font-size:0pt;"></p></td><td valign="top" align="left" style="width: 18.00pt;">
			<p style="border-top:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
				<font style="margin:0pt 0pt 12pt;font-family:Symbol;color:#000000;border-top:1pt none #D9D9D9;font-size:10pt;;"> &#xB7;</font>
			</p>
		</td><td style="width:0pt;"><p style="width:0pt;width:0pt;font-size:0pt;"></p></td><td align="left" valign="top">
			<p style="border-top:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt;margin:0pt 0pt 12pt;">
			<font style="display: inline;color:#000000;">The description of our </font><font style="display: inline;color:#000000;">common stock</font><font style="display: inline;color:#000000;"> contained in the Registration Statement on Form 8-A relating thereto, filed on October 6, 2010, including any amendment or report filed for the purpose of updating such description.</font></p></td></tr></table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">You may request a copy of these filings, at no cost, by writing or telephoning us at the following address:</font>
		</p>
		<p style="margin:0pt;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Pacific Biosciences of California, Inc.</font>
		</p>
		<p style="margin:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">1305 O&#x2019;Brien Drive</font>
		</p>
		<p style="margin:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Menlo Park, California 94025</font>
		</p>
		<p style="margin:0pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">Attn: Investor Relations</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">(650) 521-8000</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			&nbsp;
		</p></div><div style="margin-left:50pt;margin-right:50pt;">
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="font-size:10pt;display: inline;"></font><font style="font-size:10pt;display: inline;">11</font><font style="font-size:10pt;display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;color:#000000;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;"><img src="pacb-20210416xs3g001.jpg" style="width: 2.989583in; height: 1.04775in" alt="Picture 3"></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;color:#000000;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;color:#000000;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			&nbsp;
		</p></div><div style="margin-left:72pt;margin-right:54pt;">
		<p style="margin:0pt 0pt 12pt;border-bottom:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;border-bottom:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;">PART II</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">INFORMATION NOT REQUIRED IN PROSPECTUS</font>
		</p>
		<p style="margin:0pt 0pt 12pt 45pt;text-indent: -45pt;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Item 14.</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 21pt 0pt 0pt;"></font><font style="display: inline;">Other Expenses of Issuance and Distribution </font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">The following table sets forth estimated expenses in connection with the issuance and distribution of the securities being registered:</font>
		</p>
		<p style="margin:0pt;border-bottom:1pt none #D9D9D9 ;line-height:65%;text-indent:0pt;text-decoration:underline;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;border-top:1pt none #D9D9D9 ;line-height:65%;text-indent:0pt;text-decoration:underline;font-family:Times New Roman;font-size: 1pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:106pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;font-size:1pt;"></font></font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="middle" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="middle" style="width:25.45pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:132.60pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #auto;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">&#xFEFF;</font></p>
				</td>
				<td colspan="2" valign="bottom" style="width:158.05pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #auto;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 8pt">
						<font style="display: inline;font-weight:bold;font-size:8pt;">Amount to be Paid</font></p>
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">SEC registration fee</font></p>
				</td>
				<td valign="middle" style="width:25.45pt;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">$</font></p>
				</td>
				<td valign="bottom" style="width:132.60pt;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap">70,053&nbsp;
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Accounting fees and expenses </font></p>
				</td>
				<td valign="middle" style="width:25.45pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:132.60pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap">7,500&nbsp;
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Legal fees and expenses</font></p>
				</td>
				<td valign="middle" style="width:25.45pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:132.60pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap">15,000&nbsp;
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Miscellaneous expenses&nbsp; </font></p>
				</td>
				<td valign="bottom" style="width:25.45pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:132.60pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap">1,000&nbsp;
				</td>
			</tr>
			<tr>
				<td valign="middle" style="width:327.95pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt 18pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Total</font></p>
				</td>
				<td valign="middle" style="width:25.45pt;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
					<p style="margin:0pt 0pt 0.05pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">$</font></p>
				</td>
				<td valign="bottom" style="width:132.60pt;border-top:1pt solid #000000 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;;font-family:Times New Roman;font-size:10pt;text-align:right;" nowrap="nowrap">93,553&nbsp;
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt;border-bottom:1pt none #D9D9D9 ;line-height:65%;text-indent:0pt;text-decoration:underline;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;border-top:1pt none #D9D9D9 ;line-height:65%;text-indent:0pt;text-decoration:underline;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:106pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font></font>
		</p>
		<p style="margin:0pt 0pt 12pt 18pt;text-indent:-18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">*</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;"></font><font style="display: inline;">Estimate</font><font style="display: inline;">.</font>
		</p>
		<p style="margin:0pt 0pt 12pt 45pt;text-indent: -45pt;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Item 15.</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 21pt 0pt 0pt;"></font><font style="display: inline;">Indemnification of Directors and Officers</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Section 145 of the General Corporation Law of the State of Delaware empowers a corporation to indemnify its directors and officers and to purchase insurance with respect to liability arising out of their capacity or status as directors and officers, provided that the person acted in good faith and in a manner the person reasonably believed to be in our best interests, and, with respect to any criminal action, had no reasonable cause to believe the person&#x2019;s actions were unlawful. The General Corporation Law of the State of Delaware further provides that the indemnification permitted thereunder shall not be deemed exclusive of any other rights to which the directors and officers may be entitled under the corporation&#x2019;s bylaws, any agreement, a vote of stockholders or otherwise. Our certificate of incorporation provides for the indemnification of our directors and officers to the fullest extent permitted under the General Corporation Law of the State of Delaware. In addition, our bylaws require us to fully indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by reason of the fact that such person is or was our director or officer, or is or was serving at our request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorney&#x2019;s fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, to the fullest extent permitted by applicable law.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Section 102(b)(7) of the General Corporation Law of the State of Delaware permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except (1) for any breach of the director&#x2019;s duty of loyalty to the corporation or its stockholders, (2) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (3) for payments of unlawful dividends or unlawful stock repurchases or redemptions or (4) for any transaction from which the director derived an improper personal benefit. Our certificate of incorporation provides that our directors shall not be personally liable to the registrant or its stockholders for monetary damages for breach of fiduciary duty as a director and that if the General Corporation Law of the State of Delaware is amended to authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of our directors shall be eliminated or limited to the fullest extent permitted by the General Corporation Law of the State of Delaware, as so amended.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Section 174 of the General Corporation Law of the State of Delaware provides, among other things, that a director who willfully or negligently approves of an unlawful payment of dividends or an unlawful stock purchase or redemption may be held liable for such actions. A director who was either absent when the unlawful actions were approved, or dissented at the time, may avoid liability by causing his or her dissent to such actions to be entered in the books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director receives notice of the unlawful acts</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">II-</font><font style="display: inline;"></font><font style="display: inline;">1</font><font style="display: inline;"></font>

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;">Our policy is to enter into separate indemnification agreements with each of our directors and officers that provide the maximum indemnity allowed to directors and executive officers by Section 145 of the General Corporation Law of the State of Delaware and also to provide for certain additional procedural protections. We also maintain directors and officers insurance to insure such persons against certain liabilities.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">These indemnification provisions and the indemnification agreements entered into between us and our officers and directors may be sufficiently broad to permit indemnification of </font><font style="display: inline;">our</font><font style="display: inline;"> officers and directors for liabilities (including reimbursement of expenses incurred) arising under the Securities Act.</font>
		</p>
		<p style="margin:0pt 0pt 12pt 45pt;text-indent: -45pt;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Item 16.</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 21pt 0pt 0pt;"></font><font style="display: inline;">Exhibits</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
			<tr>
				<td valign="bottom" style="width:64.45pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:246.05pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:40.50pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:45.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="bottom" style="width:90.00pt;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:64.45pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font></p>
				</td>
				<td valign="bottom" style="width:246.05pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td colspan="3" valign="bottom" style="width:175.50pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Incorporation by Reference</font></p>
				</td>
			</tr>
			<tr>
				<td valign="bottom" style="width:64.45pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Exhibit No.</font></p>
				</td>
				<td valign="bottom" style="width:246.05pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Exhibit Description</font></p>
				</td>
				<td valign="bottom" style="width:40.50pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Form</font></p>
				</td>
				<td valign="bottom" style="width:45.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Exhibit No. </font></p>
				</td>
				<td valign="bottom" style="width:90.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Date</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">1.1*</font></p>
				</td>
				<td valign="top" style="width:246.05pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Form of Underwriting Agreement</font></p>
				</td>
				<td valign="top" style="width:40.50pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">--</font></p>
				</td>
				<td valign="top" style="width:45.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">--</font></p>
				</td>
				<td valign="top" style="width:90.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">--</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">3.1</font></p>
				</td>
				<td valign="top" style="width:246.05pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312511075269/dex31.htm" style="-sec-extract:exhibit"><font style="display: inline;">Amended and Restated Certificate of Incorporation</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">10-K</font></p>
				</td>
				<td valign="top" style="width:45.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">3.1</font></p>
				</td>
				<td valign="top" style="width:90.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">March 23, 2011</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">3.2</font></p>
				</td>
				<td valign="top" style="width:246.05pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312518318421/d647083dex31.htm" style="-sec-extract:exhibit"><font style="display: inline;">Second Amended and Restated Bylaws</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">8-K</font></p>
				</td>
				<td valign="top" style="width:45.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">3.1</font></p>
				</td>
				<td valign="top" style="width:90.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">November 5, 2018</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">4.1</font></p>
				</td>
				<td valign="top" style="width:246.05pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000129913021000049/pacb-20210216xex4_1.htm" style="-sec-extract:exhibit"><font style="display: inline;">Indenture, dated February 16, 2021, between Pacific Biosciences of California, Inc. and U.S. Bank National Association, as Trustee</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">8-K</font></p>
				</td>
				<td valign="top" style="width:45.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">4.1</font></p>
				</td>
				<td valign="top" style="width:90.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">February 17, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">5.1</font></p>
				</td>
				<td valign="top" style="width:246.05pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="pacb-20210416xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;">Opinion of Wilson Sonsini Goodrich&nbsp;&amp; Rosati Professional Corporation</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:45.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:90.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Filed herewith</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">10.1</font></p>
				</td>
				<td valign="top" style="width:246.05pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="http://www.sec.gov/Archives/edgar/data/1299130/000119312521035435/d121704dex101.htm" style="-sec-extract:exhibit"><font style="display: inline;">Investment Agreement, dated as of February 9, 2021, between Pacific Biosciences of California, Inc. and SB Northstar LP</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">8-K</font></p>
				</td>
				<td valign="top" style="width:45.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">10.1</font></p>
				</td>
				<td valign="top" style="width:90.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">February 10, 2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">23.1</font></p>
				</td>
				<td valign="top" style="width:246.05pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="pacb-20210416xex23_1.htm" style="-sec-extract:exhibit"><font style="display: inline;">Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:45.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:90.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Filed herewith</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">23.2</font></p>
				</td>
				<td valign="top" style="width:246.05pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="pacb-20210416xex5_1.htm" style="-sec-extract:exhibit"><font style="display: inline;">Consent of Wilson Sonsini Goodrich&nbsp;&amp; Rosati, Professional Corporation (included in the opinion filed as Exhibit&nbsp;5.1 to this Registration Statement)</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:45.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:90.00pt;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Filed herewith</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:64.45pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">24.1</font></p>
				</td>
				<td valign="top" style="width:246.05pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<a href="#PowerofAttorney"><font style="display: inline;">Power of Attorney (included on the signature page to this Registration Statement)</font></a></p>
				</td>
				<td valign="top" style="width:40.50pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:45.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:90.00pt;background-color: #CCEEFF;padding:0pt 6.9pt;">
					<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Filed herewith</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:65%;text-indent:0pt;text-decoration:underline;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:106pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font></font>
		</p>
		<p style="margin:0pt 0pt 12pt 18pt;text-indent:-18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">*</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;">To be filed by amendment or as an exhibit to a document to be incorporated by reference herein in connection with an offering of securities.</font>
		</p>
		<p style="margin:12pt 0pt 12pt 45.35pt;text-indent: -45.35pt;font-weight:bold;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Item 17.</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 21pt 0pt 0pt;"></font><font style="display: inline;">Undertakings</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">(a)</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;">The undersigned registrant hereby undertakes:</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:54pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(1)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">to file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-bottom:1pt none #D9D9D9 ;text-indent:108pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:27pt;"><font style="display: inline;">(i)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:num"><font style="display: inline;">to include any prospectus required by Section&nbsp;10(a)(3) of the Securities Act;</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:108pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(ii)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:num"><font style="display: inline;">to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Securities and Exchange Commission, or the Commission, pursuant to Rule&nbsp;424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the </font>
		</font></p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">II-</font><font style="display: inline;"></font><font style="display: inline;">2</font><font style="display: inline;"></font>

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt"><font style="display: inline;">maximum aggregate offering price set forth in the &#x201C;Calculation of Registration Fee&#x201D; table in the effective registration statement; and</font>
		</p>
		<p style="margin:0pt 0pt 12pt;border-top:1pt none #D9D9D9 ;text-indent:108pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:23pt;"><font style="display: inline;">(iii)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:num"><font style="display: inline;">to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-style:italic;color:#000000;">provided</font><font style="display: inline;color:#000000;">, &nbsp;</font><font style="display: inline;font-style:italic;color:#000000;">however</font><font style="display: inline;color:#000000;">, that paragraphs (1)(i), (1)(ii) and (1)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section&nbsp;13 or Section&nbsp;15(d) of the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule&nbsp;424(b) that is part of the registration statement.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:54pt;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(2)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">that, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-style:italic;">bona fide </font><font style="display: inline;">offering thereof.</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:54pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(3)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:54pt;border-top:1pt none #D9D9D9 ;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(4)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">that, for the purpose of determining liability under the Securities Act to any purchaser:</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:27pt;"><font style="display: inline;">(i)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">each prospectus filed by the registrant pursuant to Rule&nbsp;424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(ii)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">each prospectus required to be filed pursuant to Rule&nbsp;424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule&nbsp;430B relating to an offering made pursuant to Rule&nbsp;415(a)(1)(i), (vii)&nbsp;or (x) for the purpose of providing the information required by Section&nbsp;10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule&nbsp;430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-style:italic;">bona fide </font><font style="display: inline;">offering thereof. </font><font style="display: inline;font-style:italic;">Provided, however</font><font style="display: inline;">, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date.</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:54pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(5)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">that, for the purpose of determining liability of a registrant under the Securities Act to any purchaser in the initial distribution of the securities, the undersigned registrant undertakes that in a primary offering of securities of such undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:27pt;"><font style="display: inline;">(i)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule&nbsp;424;</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(ii)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">II-</font><font style="display: inline;"></font><font style="display: inline;">3</font><font style="display: inline;"></font>

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;;font-size: 10pt"><font style="text-indent:0pt;margin-left:0pt; padding-right:23pt;"><font style="display: inline;">(iii)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">the portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:90pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:23pt;"><font style="display: inline;">(iv)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:54pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:25pt;"><font style="display: inline;">(6)</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">that, for purposes of determining any liability under the Securities Act, each filing of the registrant&#x2019;s annual report pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan&#x2019;s annual report pursuant to Section&nbsp;15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial </font><font style="display: inline;font-style:italic;">bona fide</font><font style="display: inline;"> offering thereof.</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">(b)</font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;"></font><font style="display: inline;color:#000000;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">II-</font><font style="display: inline;"></font><font style="display: inline;">4</font><font style="display: inline;"></font>

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:0pt 0pt 12pt;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;;font-size: 10pt"><font style="display: inline;color:#000000;"></font><font style="display: inline;">SIGNATURES</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form&nbsp;S</font><font style="display: inline;">&#8209;3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on </font><font style="display: inline;">April 16, </font><font style="display: inline;">2021</font><font style="display: inline;">.</font>
		</p>
		<p style="margin:0pt 0pt 12pt 252pt;line-height:97.08%;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;font-weight:bold;text-transform:uppercase;">Pacific Biosciences of California, Inc.</font>
		</p>
		<p style="margin:0pt 0pt 0pt 252pt;line-height:97.08%;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:9.60000000000002pt;"><font style="display: inline;">By:</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:206.8pt;text-align:left"><font style="display: inline;"></font><font style="display: inline;font-style:italic;text-decoration:underline;">/s/</font><font style="display: inline;text-decoration:underline;"> Eric E. Schaefer</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;text-decoration:underline;"></font></font>
		</p>
		<p style="margin:0pt 0pt 0pt 252pt;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">Eric E. Schaefer</font></font>
		</p>
		<p style="margin:0pt 0pt 12pt 252pt;border-top:1pt none #D9D9D9 ;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;">Vice President and Chief Accounting Officer</font></font>
		</p>
		<p style="margin:24pt 0pt 12pt;font-weight:bold;text-indent:0pt;text-align:center;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">POWER OF AT</font><a name="PowerofAttorney"></a><font style="display: inline;">TORNEY</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints </font><font style="display: inline;color:#000000;">Christian O. Henry, Susan G. Kim, Brett Atkins and Eric E. Schaefer,</font><font style="display: inline;">&nbsp;</font><font style="display: inline;">and each of them, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments to this registration statement, including post-effective amendments, and registration statements filed pursuant to Rule&nbsp;462 under the Securities Act, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith and about the premises, as fully for all intents and purposes as they, he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent or any of them, or their, his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated:</font>
		</p>
		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:38.60%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size: 1pt">
						<font style="display: inline;font-size:1pt;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:42.54%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
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				<td valign="top" style="width:18.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;border-right:1pt none #D9D9D9 ;height:1.00pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;height:1.00pt;overflow:hidden;font-size:0pt;">
						&nbsp;</p>
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					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Signature</font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Title</font></p>
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					<p style="margin:0pt 0pt 3pt;border-bottom:1pt solid #000000 ;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;font-weight:bold;">Date</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
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					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;height:23.05pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:56.8pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:75.5pt;text-align:center"><font style="display: inline;">/s/</font><font style="display: inline;"> Christian O. Henry</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font></font></p>
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Christian O. Henry</font></p>
				</td>
				<td valign="top" style="width:42.54%;height:23.05pt;padding:0pt 6.5pt;">
					<p style="margin:0pt;line-height:normal;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;color:#000000;">Director, Chief Executive Officer</font></p>
					<p style="margin:0pt;line-height:normal;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;color:#000000;">and President</font><br /><font style="display: inline;">(Principal Executive Officer)</font></p>
				</td>
				<td valign="top" style="width:18.86%;height:23.05pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;height:23.05pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:56.8pt;"></font><font style="text-indent:0pt;margin-left:0pt; padding-right:75.5pt;text-align:center"><font style="display: inline;">/s/</font><font style="display: inline;"> Susan G. Kim</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font></font></p>
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Susan G. Kim</font></p>
				</td>
				<td valign="top" style="width:42.54%;height:23.05pt;padding:0pt 6.5pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Chief Financial Officer </font><br /><font style="display: inline;">(Principal Financial Officer)</font></p>
				</td>
				<td valign="top" style="width:18.86%;height:23.05pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;height:9.00pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;text-decoration:underline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:42.54%;height:9.00pt;padding:0pt 6.5pt;">
					<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.86%;height:9.00pt;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;overflow: hidden;font-size:0pt;">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:61.65pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.65pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ Eric E. Schaefer</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">Eric E. Schaefer</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Vice President and Chief Accounting Officer</font><br /><font style="display: inline;">(Principal Accounting Officer)</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:61.8pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:13.5pt;text-align:center"><font style="display: inline;">/s/ John F. Milligan</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">John F. Milligan</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Chairman of the Board of Directors</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">&#xFEFF;</font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						&nbsp;</p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.05pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ David Botstein</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">David Botstein</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.05pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ William W. Ericson</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">William W. Ericson</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr></table>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">II-</font><font style="display: inline;"></font><font style="display: inline;">5</font><font style="display: inline;"></font>

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-align:right;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<table cellpadding="0" cellspacing="0" style="border-collapse:collapse;margin-left:0pt;">
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.05pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ Michael Hunkapiller</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">Michael Hunkapiller</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ Randall S. Livingston</font></font><font style="display: inline;;font-size: 10pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">Randall S. Livingston</font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.05pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ Marshall L. Mohr</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">Marshall L. Mohr</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.05pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ Kathy Ordo&#xF1;ez</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">Kathy Ordo&#xF1;ez</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
			<tr>
				<td valign="top" style="width:38.60%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;border-bottom:1pt solid #000000 ;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="text-indent:0pt;margin-left:0pt; padding-right:62.25pt;"><font style="display: inline;">&nbsp;</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:83.05pt;text-align:center"><font style="display: inline;font-size:5pt;vertical-align:super;line-height:100%"></font><font style="display: inline;">/s/ Lucy Shapiro</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;"></font><br /><font style="display: inline;"></font><font style="display: inline;">Lucy Shapiro</font></font></p>
				</td>
				<td valign="top" style="width:42.54%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">Director</font></p>
				</td>
				<td valign="top" style="width:18.86%;padding:0pt 6.5pt;">
					<p style="margin:0pt 0pt 12pt;text-align:center;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
						<font style="display: inline;">April 16, </font><font style="display: inline;">2021</font></p>
				</td>
			</tr>
		</table></div>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 12pt;text-indent:18pt;font-family:Times New Roman;font-size: 10pt">
			<font style="display: inline;">&#xFEFF;</font>
		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:0pt;text-align:center;text-indent:0pt;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">II-</font><font style="display: inline;"></font><font style="display: inline;">6</font><font style="display: inline;"></font>

		</p>

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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>pacb-20210416xex5_1.htm
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		<title>
			Exhibit 5.1
		</title>
	</head>
	<body><div style="margin-left:72pt;margin-right:54pt;"><div style="width:100%">

		<p style="margin:12pt 0pt;text-indent:0pt;text-align:right;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">

			<font style="display: inline;font-weight:bold;font-size:11pt;">Exhibit 5.1</font>

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		<div style="width:100%"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width:490.50pt;margin-left:0pt;">

			<tr>

				<td valign="top" style="width:247.50pt;height:72.00pt;padding:0pt 6.9pt;">

					<p style="margin:6pt 0pt 0pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;overflow: hidden;font-size:0pt;">

						<font style="text-indent:0pt;margin-left:0pt; padding-right:133pt;"><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;"></font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;"></font></font></p>

				</td>

				<td valign="top" style="width:243.00pt;height:72.00pt;padding:0pt 6.9pt;">

					<p style="margin:6pt 3.6pt 0pt 97.05pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 8pt">

						<font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;">Wilson Sonsini Goodrich &amp; Rosati</font><br /><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;">Professional Corporation</font></p>

					<p style="margin:4pt 5.5pt 0pt 97.05pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 8pt">

						<font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;">650 Page Mill Road</font><br /><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;">Palo Alto, California 94304-1050</font></p>

					<p style="margin:4pt 3.6pt 0pt 87pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 8pt">

						<font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o</font><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;">: 650.493.9300</font><br /><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;"></font><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;f</font><font style="display: inline;font-family:Georgia;color:#003D4C;font-size:8pt;">: 650.493.6811</font></p>

				</td>

			</tr>

		</table></div>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:12pt 0pt 0pt 36pt;text-indent:36pt;text-align:center;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">April 16, 2021</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">Pacific Biosciences of California, Inc.</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">1305 O&#x2019;Brien Drive</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">Menlo Park, California 94025</font>
		</p>
		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 72pt;text-indent:0pt;text-align:left;font-weight:bold;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">Re:</font><font style="display: inline;font-size:11pt;;font-size: 11pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;font-size:11pt;">Registration Statement on Form S-3</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;color:#000000;font-size:11pt;">Ladies and Gentlemen:</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:45pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;color:#000000;font-size:11pt;">This opinion is furnished to you in connection with the Registration Statement on Form S</font><font style="display: inline;color:#000000;font-size:11pt;">&#8209;3 (the &#x201C;</font><font style="display: inline;font-weight:bold;color:#000000;font-size:11pt;">Registration Statement</font><font style="display: inline;color:#000000;font-size:11pt;">&#x201D;), to be filed on or about </font><font style="display: inline;color:#000000;font-size:11pt;">April 16, 2021</font><font style="display: inline;color:#000000;font-size:11pt;"> by Pacific Biosciences of California, Inc. (the &#x201C;</font><font style="display: inline;font-weight:bold;color:#000000;font-size:11pt;">Company</font><font style="display: inline;color:#000000;font-size:11pt;">&#x201D;) with the Securities and Exchange Commission in connection with the registration for resale under the Securities Act of 1933, as amended (the &#x201C;</font><font style="display: inline;font-weight:bold;color:#000000;font-size:11pt;">Securities Act</font><font style="display: inline;color:#000000;font-size:11pt;">&#x201D;), of up to </font><font style="display: inline;color:#000000;font-size:11pt;">20,689,650</font><font style="display: inline;color:#000000;font-size:11pt;">&nbsp;</font><font style="display: inline;color:#000000;font-size:11pt;">shares of the Company&#x2019;s common stock, </font><font style="display: inline;color:#000000;font-size:11pt;">$0.001 </font><font style="display: inline;color:#000000;font-size:11pt;">par value per share (the &#x201C;</font><font style="display: inline;font-weight:bold;color:#000000;font-size:11pt;">Shares</font><font style="display: inline;color:#000000;font-size:11pt;">&#x201D;)</font><font style="display: inline;color:#000000;font-size:11pt;">&nbsp;</font><font style="display: inline;color:#000000;font-size:11pt;">issuable upon conversion of the Company&#x2019;s 1.5% Convertible Senior Notes due 2028 (the &#x201C;</font><font style="display: inline;font-weight:bold;color:#000000;font-size:11pt;">Notes</font><font style="display: inline;color:#000000;font-size:11pt;">&#x201D;)</font><font style="display: inline;color:#000000;font-size:11pt;"> in accordance with the Indenture, dated as of February 16, 2021 between the Company and U.S. Bank National Association, as trustee (&#x201C;the </font><font style="display: inline;font-weight:bold;color:#000000;font-size:11pt;">Indenture</font><font style="display: inline;color:#000000;font-size:11pt;">&#x201D;)</font><font style="display: inline;color:#000000;font-size:11pt;">.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:45pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;color:#000000;font-size:11pt;">We are acting as counsel for the Company in connection with the registration for resale under the Securities Act of the Shares. In such capacity, we have examined originals or copies, certified or otherwise identified to our satisfaction, of such documents, corporate records, certificates of public officials and other instruments as we have deemed necessary for the purposes of rendering this opinion. In our examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity with the originals of all documents submitted to us as copies, the authenticity of the originals of such documents and the legal competence of all signatories to such documents.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:45pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;color:#000000;font-size:11pt;">We express no opinion herein as to the laws of any state or jurisdiction other than the General Corporation Law of the State of Delaware (including the statutory provisions and all applicable judicial decisions interpreting those laws) and the federal laws of the United States of America.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:47.05pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">We express no opinion as to (i) the effect of any bankruptcy, insolvency, reorganization, arrangement, fraudulent conveyance, moratorium or other similar laws relating to or affecting the rights of creditors generally, (ii) rights to indemnification and contribution which may be limited by applicable law or equitable principles, or (iii) the effect of general principles of equity, including, without limitation, concepts of materiality, reasonableness, good faith and fair dealing, the effect of judicial discretion and the possible unavailability of specific performance, injunctive relief or other equitable relief, and the limitations on rights of acceleration, whether considered in a proceeding in equity or at law. </font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:45pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;color:#000000;font-size:11pt;">On the basis of the foregoing, we are of the opinion that </font><font style="display: inline;color:#000000;font-size:11pt;">when </font><font style="display: inline;color:#000000;font-size:11pt;">the conversion right has been duly exercised in accordance with the terms of the Notes and the Indenture</font><font style="display: inline;color:#000000;font-size:11pt;">,</font><font style="display: inline;color:#000000;font-size:11pt;"> and the Shares have been issued and delivered upon such exercise in accordance with the terms of the Notes and the Indenture, the Shares</font><font style="display: inline;color:#000000;font-size:11pt;"> will be</font><font style="display: inline;color:#000000;font-size:11pt;">&nbsp;</font><font style="display: inline;color:#000000;font-size:11pt;">validly issued, fully paid and nonassessable.</font>
		</p>
		<p style="margin:12pt 0pt 0pt;text-indent:45pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">

		</p>
		<p><font size="1"> </font></p><div style="width:100%">

		<p style="margin:3pt -27.35pt;line-height:135%;text-indent:0pt;text-align:center;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 7pt">

			<font style="display: inline;font-family:Buenos Aires;text-transform:uppercase;color:#003D4C;font-size:7pt;">austin&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;beijing&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;boston&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;brussels&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;hong kong&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;london&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;los angeles&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;new york&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;palo alto</font><br /><font style="display: inline;font-family:Buenos Aires;text-transform:uppercase;color:#003D4C;font-size:7pt;">san diego&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;san francisco&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;seattle&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;shanghai&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;washington, dc&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;wilmington, de</font>

		</p>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p><div style="width:100%">

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;"></font>

		</p>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">Pacific Biosciences of California, Inc.</font>

		</p>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">Registration Statement on Form S-3</font>

		</p>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			<font style="display: inline;">April </font><font style="display: inline;">16</font><font style="display: inline;">, 2021</font>

		</p>

		<p style="margin:0pt;text-indent:0pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 10pt">

			&nbsp;

		</p>

</div>
		<p style="margin:12pt 0pt 0pt;text-indent:45pt;text-align:justify;text-justify:inter-ideograph;font-family:Times New Roman;;font-size: 11pt"><font style="display: inline;color:#000000;font-size:11pt;">We consent to the use of this opinion as an exhibit to the Registration Statement, and we consent to the reference of our name under the caption &#x201C;Legal Matters&#x201D; in the prospectus forming part of the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Securities and Exchange Commission thereunder.</font>
		</p>
		<p style="margin:0pt 0pt 0pt 234pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt 0pt 0pt 234pt;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;"></font><font style="display: inline;font-size:11pt;"></font><font style="display: inline;font-size:11pt;"></font><font style="display: inline;font-size:11pt;">Sincerely,</font><font style="display: inline;font-size:11pt;"></font>
		</p>
		<p style="margin:0pt 0pt 0pt 234pt;border-bottom:1pt none #D9D9D9 ;text-indent:0pt;text-align:left;text-justify:inter-ideograph;font-family:Times New Roman;font-size: 11pt">
			<font style="display: inline;font-size:11pt;">&#xFEFF;</font>
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			<font style="display: inline;font-size:11pt;">/s/ Wilson Sonsini Goodrich &amp; Rosati</font>
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			<font style="display: inline;font-size:11pt;">WILSON SONSINI GOODRICH &amp; ROSATI</font>
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			<font style="display: inline;font-size:11pt;">Professional Corporation</font>
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			<font style="font-size: 12pt;font-family:Times New Roman;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display: inline;">-</font><font style="font-family:Times New Roman;font-size:12pt;display: inline;"></font><font style="font-family:Times New Roman;font-size:12pt;display: inline;">2</font><font style="font-family:Times New Roman;font-size:12pt;display: inline;"></font><font style="font-family:Times New Roman;font-size:12pt;display: inline;">- &nbsp;</font>

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<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>pacb-20210416xex23_1.htm
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			Exhibit 23.1
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			<font style="display: inline;font-family:EYInterstate Light;font-weight:bold;color:#000000;font-size:10pt;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</font>
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			<a name="_Hlk64445370"></a><font style="color:#008000;display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">We consent to the reference to our firm under the caption "Experts" in the Registration Statement (Form S-3) and related Prospectus of Pacific Biosciences of California, Inc. for the registration of 20,689,650 shares of its </font><font style="color:#008000;display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">c</font><font style="color:#008000;display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">ommon </font><font style="color:#008000;display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">s</font><font style="color:#008000;display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">tock and to the incorporation by reference therein of our report dated&nbsp;February 26, 2021, with respect to the consolidated financial statements of Pacific Biosciences of California, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission</font><font style="color:#008000;display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">.</font>
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			<font style="display: inline;font-family:EYInterstate Light;font-size:10pt;">/s/ Ernst &amp; Young LLP</font>
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			<font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">Redwood City, California</font>
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			<font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">April 16</font><font style="display: inline;font-family:EYInterstate Light;color:#000000;font-size:10pt;">, 2021</font>
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