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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2021
Reconciliation of Outstanding and Exercisable Stock Options | Options Outstanding Options Exercisable Number Weighted average Number outstanding remaining contractual Weighted average vested Weighted average Exercise price(in 000s) life (Years) exercise price (in 000s) exercise price $0.00 - 4.64 3,676 5.37 $ 2.91 3,508 $ 2.91 $4.64 - 9.27 5,480 5.88 $ 6.64 4,010 $ 6.68 $9.27 - 13.91 702 6.69 $ 9.81 427 $ 9.94 $13.91 - 18.55 35 8.79 $ 14.34 14 $ 14.34 $ 18.55 - 23.19 180 9.38 $ 21.86 25 $ 20.90 $23.19 - 27.82 320 9.50 $ 24.22 — $ — $27.82 - 32.46 472 9.43 $ 28.77 52 $ 27.90 $ 32.46 - 37.10 1,380 9.00 $ 36.18 — $ — $41.73 - 46.37 218 9.13 $ 46.37 45 $ 46.37 12,463 6.47 $ 11.22 8,081 $ 5.63
Summary of Time-Based RSUs Activity | Weighted average Number grant date of shares fair valueRSUs outstanding at December 31, 2020 5,919 $ 5.25RSUs granted 3,744 35.33RSUs released (1,798) 5.13RSUs forfeited (473) 16.68Unvested RSUs outstanding at December 31, 2021 7,392 $ 19.78
Summary of Performance-Based RSUs Activity | Weighted average Number grant date of shares fair valuePSUs outstanding at December 31, 2020 94 $$ 2.63PSUs granted — —PSUs released — —PSUs forfeited (94) 2.63Unvested PSUs outstanding at December 31, 2021 — $ —
Schedule of Stock-Based Compensation Expense | Years Ended December 31, 2021 2020 2019Cost of revenue$ 6,126 $ 2,236 $ 1,857Research and development 20,275 7,061 7,699Sales, general and administrative 35,403 8,236 6,845Merger-related expenses - stock-settled 6,349 — —Merger-related expenses - milestone 5,202 — —Stock-based compensation 73,355 17,533 16,401Merger-related expenses - cash-settled 7,373 — —Total stock-based compensation expense$ 80,728 $ 17,533 $ 16,401
Schedule of Fair Value of Employee Stock Options | Years Ended December 31, 2021 2020 2019Expected term in years 2.1 - 4.6 5.0 years — Expected volatility 67% - 80% 70.7% — Risk-free interest rate 0.05% – 1.10% 0.3% — Dividend yield — — — Weighted average grant date fair value per share $ 15.53 $ 7.20 —
Schedule of Fair Value of Employee Stock Purchase Plan | Years Ended December 31, 2021 2020 2019Expected term in years 0.5 - 2.0 0.5 - 2.0 — Expected volatility 67% - 68% 57% - 71% — Risk-free interest rate 0.1% - 0.2% 0.1%-1.0% — Dividend yield — — — Weighted average grant date fair value per share $ 25.07 $ 1.87 —
Time-based stock options [Member] |
Summary of Stock Option Activity | Stock Options Outstanding Weighted Number average of shares Exercise price exercise priceOutstanding at December 31, 2020 14,638 $ 1.16 – 20.90 $ 5.53Granted 2,489 23.06 – 46.37 33.78Assumed Omniome options 339 2.05 – 4.90 4.43Exercised (4,766) 1.16 – 15.98 5.31Canceled (541) 2.54 – 46.37 5.25Outstanding at December 31, 2021 12,159 $1.16 – 46.37 $ 11.38
Performance-based stock options [Member] |
Summary of Stock Option Activity | Stock Options Outstanding Weighted Number average of shares Exercise price exercise priceOutstanding at December 31, 2020 — $ — $ —Granted — — —Assumed Omniome options 304 4.71 - 4.90 4.71Exercised — — —Canceled — — —Outstanding at December 31, 2021 304 $4.71 - 4.90 $ 4.71

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