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Income Taxes (Reconciliation of Deferred Tax Assets and Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 378,035 | $ 233,225
Research and development credits | 60,672 | 49,179
Accruals and reserves | 10,822 | 6,337
Stock-based compensation | 12,838 | 9,717
ASC842 Operating lease liability | (13,105) | (9,870)
Total deferred tax assets | 475,472 | 308,328
Less: Valuation allowance | (366,940) | (300,505)
Total deferred tax assets: | 108,532 | 7,823
Intangibles | (97,345) |
Fixed assets | (1,523) | (786)
ASC842 Operating Lease right-of-use assets | (10,502) | (7,037)
Total deferred tax liabilities | (109,370) | (7,823)
Net deferred tax liabilities | $ (838) |

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