Financial Instruments (Tables)	12 Months Ended
Dec. 31, 2021
Financial Instruments [Abstract]
Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis	December 31, 2021 December 31, 2020 (in thousands)Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Assets Cash and cash equivalents: Cash and money market funds $ 327,315 $ — $ — $ 327,315 $ 43,040 $ — $ — $ 43,040 Commercial paper — 133,185 — 133,185 — 32,537 — 32,537 U.S. government & agency securities — 225 — 225 — 170 — 170 U.S. Treasury security — — — — — 5,864 — 5,864 Total cash and cash equivalents 327,315 133,410 — 460,725 43,040 38,571 — 81,611 Investments: Commercial paper — 187,632 — 187,632 — 112,644 — 112,644 Corporate debt securities — 8,968 — 8,968 — 17,456 — 17,456 U.S. government & agency securities — 387,075 — 387,075 — 107,103 — 107,103 Total investments — 583,675 — 583,675 — 237,203 — 237,203 Short-term restricted cash: Cash 500 — — 500 836 — — 836 Long-term restricted cash: Cash 4,592 — — 4,592 3,500 — — 3,500 Total assets measured at fair value $ 332,407 $ 717,085 $ — $ 1,049,492 $ 47,376 $ 275,774 $ — $ 323,150 Liabilities Continuation advances $ — $ — $ — $ — $ — $ — $ — $ — Contingent consideration — — 169,717 169,717 — — — — Total liabilities measured at fair value $ — $ — $ 169,717 $ 169,717 $ — $ — $ — $ —
Changes in the estimated fair value of contingent consideration liabilities [Table Text Block]	(in thousands)Level 3Beginning balance as of January 1, 2021 -Acquisition of Omniome 168,574Change in estimated fair value 1,143Ending balance as of December 31, 2021 169,717
Summary of Cash, Cash Equivalents and Investments	As of December 31, 2021 Gross Gross Amortized unrealized unrealized Fair(in thousands) Cost gains losses Value Cash and cash equivalents: Cash and money market funds$ 327,316 $ — $ — $ 327,316Commercial paper 133,190 — (5) 133,185U.S. government & agency securities 225 — — 224Total cash and cash equivalents 460,731 — (5) 460,725Investments: Commercial paper 187,705 — (73) 187,632Corporate debt securities 8,964 9 (5) 8,968U.S. government & agency securities 388,088 1 (1,014) 387,075Total investments 584,757 10 (1,092) 583,675Total cash, cash equivalents and investments $ 1,045,488 $ 10 $ (1,097) $ 1,044,400Short-term restricted cash: Cash $ 500 $ — $ — $ 500Long-term restricted cash: Cash $ 4,592 $ — $ — $ 4,592 As of December 31, 2020 Gross Gross Amortized unrealized unrealized Fair(in thousands) Cost gains losses Value Cash and cash equivalents: Cash and money market funds$ 43,040 $ — $ — $ 43,040Commercial paper 32,538 — (1) 32,537U.S. government & agency securities 170 — — 170U.S. Treasury security 5,864 — — 5,864Total cash and cash equivalents 81,612 — (1) 81,611Investments: Commercial paper 112,648 4 (8) 112,644Corporate debt securities 17,360 96 — 17,456U.S. government & agency securities 107,109 6 (12) 107,103Total investments 237,117 106 (20) 237,203Total cash, cash equivalents and investments $ 318,729 $ 106 $ (21) $ 318,814Short-term restricted cash: Cash $ 836 $ — $ — $ 836Long-term restricted cash: Cash $ 3,500 $ — $ — $ 3,500
Summary of Contractual Maturities of Cash Equivalents and Available-for-Sale Investments	(in thousands)Fair ValueDue in one year or less $ 595,063Due after one year through 5 years 122,022Total investments $ 717,085

Financial Instruments (Tables)

12 Months Ended

Dec. 31, 2021

Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis

December 31, 2021 December 31, 2020 (in thousands)Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Assets Cash and cash equivalents: Cash and money market funds $ 327,315 $ — $ — $ 327,315 $ 43,040 $ — $ — $ 43,040 Commercial paper — 133,185 — 133,185 — 32,537 — 32,537 U.S. government & agency securities — 225 — 225 — 170 — 170 U.S. Treasury security — — — — — 5,864 — 5,864 Total cash and cash equivalents 327,315 133,410 — 460,725 43,040 38,571 — 81,611 Investments: Commercial paper — 187,632 — 187,632 — 112,644 — 112,644 Corporate debt securities — 8,968 — 8,968 — 17,456 — 17,456 U.S. government & agency securities — 387,075 — 387,075 — 107,103 — 107,103 Total investments — 583,675 — 583,675 — 237,203 — 237,203 Short-term restricted cash: Cash 500 — — 500 836 — — 836 Long-term restricted cash: Cash 4,592 — — 4,592 3,500 — — 3,500 Total assets measured at fair value $ 332,407 $ 717,085 $ — $ 1,049,492 $ 47,376 $ 275,774 $ — $ 323,150 Liabilities Continuation advances $ — $ — $ — $ — $ — $ — $ — $ — Contingent consideration — — 169,717 169,717 — — — — Total liabilities measured at fair value $ — $ — $ 169,717 $ 169,717 $ — $ — $ — $ —

Changes in the estimated fair value of contingent consideration liabilities [Table Text Block]

(in thousands)Level 3Beginning balance as of January 1, 2021 -Acquisition of Omniome 168,574Change in estimated fair value 1,143Ending balance as of December 31, 2021 169,717

Summary of Cash, Cash Equivalents and Investments

As of December 31, 2021 Gross Gross Amortized unrealized unrealized Fair(in thousands) Cost gains losses Value Cash and cash equivalents: Cash and money market funds$ 327,316 $ — $ — $ 327,316Commercial paper 133,190 — (5) 133,185U.S. government & agency securities 225 — — 224Total cash and cash equivalents 460,731 — (5) 460,725Investments: Commercial paper 187,705 — (73) 187,632Corporate debt securities 8,964 9 (5) 8,968U.S. government & agency securities 388,088 1 (1,014) 387,075Total investments 584,757 10 (1,092) 583,675Total cash, cash equivalents and investments $ 1,045,488 $ 10 $ (1,097) $ 1,044,400Short-term restricted cash: Cash $ 500 $ — $ — $ 500Long-term restricted cash: Cash $ 4,592 $ — $ — $ 4,592 As of December 31, 2020 Gross Gross Amortized unrealized unrealized Fair(in thousands) Cost gains losses Value Cash and cash equivalents: Cash and money market funds$ 43,040 $ — $ — $ 43,040Commercial paper 32,538 — (1) 32,537U.S. government & agency securities 170 — — 170U.S. Treasury security 5,864 — — 5,864Total cash and cash equivalents 81,612 — (1) 81,611Investments: Commercial paper 112,648 4 (8) 112,644Corporate debt securities 17,360 96 — 17,456U.S. government & agency securities 107,109 6 (12) 107,103Total investments 237,117 106 (20) 237,203Total cash, cash equivalents and investments $ 318,729 $ 106 $ (21) $ 318,814Short-term restricted cash: Cash $ 836 $ — $ — $ 836Long-term restricted cash: Cash $ 3,500 $ — $ — $ 3,500

Summary of Contractual Maturities of Cash Equivalents and Available-for-Sale Investments

(in thousands)Fair ValueDue in one year or less $ 595,063Due after one year through 5 years 122,022Total investments $ 717,085

- Definition

Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.

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