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Stockholders' Equity (Tables)
 12 Months Ended
Dec. 31, 2021
Reconciliation of Outstanding and Exercisable Stock Options Options Outstanding Options Exercisable Number Weighted average Number outstanding remaining contractual Weighted average vested Weighted average Exercise price(in 000s) life (Years) exercise price (in 000s) exercise price $0.00 - 4.64 3,676 5.37 $ 2.91 3,508 $ 2.91 $4.64 - 9.27 5,480 5.88 $ 6.64 4,010 $ 6.68 $9.27 - 13.91 702 6.69 $ 9.81 427 $ 9.94 $13.91 - 18.55 35 8.79 $ 14.34 14 $ 14.34 $ 18.55 - 23.19 180 9.38 $ 21.86 25 $ 20.90 $23.19 - 27.82 320 9.50 $ 24.22 — $ — $27.82 - 32.46 472 9.43 $ 28.77 52 $ 27.90 $ 32.46 - 37.10 1,380 9.00 $ 36.18 — $ — $41.73 - 46.37 218 9.13 $ 46.37 45 $ 46.37 12,463 6.47 $ 11.22 8,081 $ 5.63
Summary of Time-Based RSUs Activity Weighted average Number grant date of shares fair valueRSUs outstanding at December 31, 2020 5,919 $ 5.25RSUs granted 3,744 35.33RSUs released (1,798) 5.13RSUs forfeited (473) 16.68Unvested RSUs outstanding at December 31, 2021 7,392 $ 19.78
Summary of Performance-Based RSUs Activity Weighted average Number grant date of shares fair valuePSUs outstanding at December 31, 2020 94 $$                    2.63PSUs granted — —PSUs released — —PSUs forfeited (94) 2.63Unvested PSUs outstanding at December 31, 2021 — $ —
Schedule of Stock-Based Compensation Expense Years Ended December 31, 2021 2020 2019Cost of revenue$ 6,126 $ 2,236 $ 1,857Research and development 20,275 7,061 7,699Sales, general and administrative 35,403 8,236 6,845Merger-related expenses - stock-settled 6,349 — —Merger-related expenses - milestone 5,202 — —Stock-based compensation 73,355 17,533 16,401Merger-related expenses - cash-settled 7,373 — —Total stock-based compensation expense$ 80,728 $ 17,533 $ 16,401
Schedule of Fair Value of Employee Stock Options Years Ended December 31, 2021 2020 2019Expected term in years 2.1 - 4.6 5.0 years —  Expected volatility 67% - 80% 70.7% —  Risk-free interest rate 0.05% – 1.10% 0.3% —  Dividend yield —   —   —  Weighted average grant date fair value per share $                         15.53 $               7.20 —  
Schedule of Fair Value of Employee Stock Purchase Plan Years Ended December 31, 2021 2020 2019Expected term in years 0.5 - 2.0 0.5 - 2.0 —  Expected volatility 67% - 68% 57% - 71% —  Risk-free interest rate 0.1% - 0.2% 0.1%-1.0% —  Dividend yield — —   —  Weighted average grant date fair value per share $                  25.07 $                    1.87 —  
Time-based stock options [Member]  
Summary of Stock Option Activity Stock Options Outstanding Weighted Number average of shares Exercise price exercise priceOutstanding at December 31, 2020 14,638 $ 1.16 – 20.90 $ 5.53Granted 2,489 23.06 – 46.37 33.78Assumed Omniome options 339 2.05 – 4.90 4.43Exercised (4,766) 1.16 – 15.98 5.31Canceled (541) 2.54 – 46.37 5.25Outstanding at December 31, 2021 12,159 $1.16 – 46.37 $ 11.38
Performance-based stock options [Member]  
Summary of Stock Option Activity Stock Options Outstanding Weighted Number average of shares Exercise price exercise priceOutstanding at December 31, 2020 — $ — $ —Granted — — —Assumed Omniome options 304 4.71 - 4.90 4.71Exercised — — —Canceled — — —Outstanding at December 31, 2021 304 $4.71 - 4.90 $ 4.71