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Business Acquisitions (Narrative) (Details) - USD ($)
 12 Months Ended
Sep. 20, 2021
Jul. 20, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Business Acquisition [Line Items]          
Issuance of common stock in Private Placement, net of issuance costs shares 11,214,953        
Proceeds From Issuance Of Common Stock     $ 31,806,000 $ 46,360,000 $ 8,548,000
Issuance of common stock in Private Placement, net of issuance costs     294,845,000    
Acquisition-related costs     31,129,000    
Stock-based compensation expense     80,728,000 $ 17,533,000 $ 16,401,000
Goodwill     409,974,000    
Finite-Lived Intangible Assets, Gross   $ 11,400,000 11,360,000    
Income Tax Expense (Benefit)     (93,649,000)    
Circulomics, Inc [Member]          
Business Acquisition [Line Items]          
Total cash paid   29,500,000      
Goodwill   19,309,000      
Omniome, Inc [Member]          
Business Acquisition [Line Items]          
Total cash paid $ 315,703,000        
Fair value of share consideration 249,435,000        
Contingent Consideration Incurred during period $ 168,574,000        
Issuance of common stock 8,911,580        
Consideration $ 714,789,000        
Price Per Share $ 26.75        
Proceeds From Issuance Of Common Stock $ 294,800,000        
Estimated issuance costs 5,200,000        
Acquisition-related costs 12,000,000.0   12,000,000.0    
Stock-based compensation expense 18,900,000        
Income tax benefit from reduction in deferred tax assets valuation allowance 91,000,000.0        
Pro forma adjustment related to acquiree's acquisition-related costs 16,700,000        
Since the date of acquisition, revenues     0    
Since the date of acquisition, net loss     15,600,000    
Goodwill 390,665,000        
Omniome, Inc [Member] | Effect of Change Higher/(Lower) [Member]          
Business Acquisition [Line Items]          
Goodwill     (1,600,000)    
Deferred Tax Liabilities, Deferred Expense     (400,000)    
Income Tax Expense (Benefit)     (1,200,000)    
Omniome, Inc [Member] | Omniome stock awards related to acquisition [Member]          
Business Acquisition [Line Items]          
Total cash paid 7,400,000        
Fair value of share consideration 6,300,000        
Contingent Consideration Incurred during period $ 5,200,000        
Issuance of common stock 226,811        
Consideration $ 18,900,000        
Achievement of milestone [Member] | Omniome, Inc [Member]          
Business Acquisition [Line Items]          
Total cash paid 100,000,000        
Fair value of share consideration 100,000,000        
Fair value of contingent consideration 200,000,000        
Stock options issued by PacBio in replacement of Omniome’s unvested options 4,100,000        
In Process Research and Development [Member] | Omniome, Inc [Member]          
Business Acquisition [Line Items]          
Finite-Lived Intangible Assets, Gross $ 400,000,000        
Developed Technology [Member]          
Business Acquisition [Line Items]          
Finite-Lived Intangible Assets, Gross   $ 11,000,000.0 $ 11,000,000