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Balance Sheet Components (Narrative) (Details)
 1 Months Ended 12 Months Ended
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Oct. 31, 2015
USD ($)
Balance Sheet Components [Line Items]            
Percentage of fee to prepay debt   4        
Short-term restricted cash   $ 500,000 $ 836,000      
Depreciation   7,199,000 6,428,000 $ 7,265,000 $ 7,300,000  
Long-term restricted cash   4,592,000 3,500,000      
May 1 annual decrease to long-term restricted cash   500,000        
Amortization of intangible assets   400,000 0 $ 0    
Deferred revenue, current   10,977,000 8,722,000      
Deferred revenue, non-current   $ 25,049,000 1,568,000      
Revenue recognized     8,600,000      
Deferred service revenue, noncurrent, recognition period   5 years        
Prepaid expenses and other current assets   $ 7,394,000 4,870,000      
Notes Payable   3,900,000        
Notes payable, current   1,600,000        
Long Term Notes Payable   2,300,000        
Interest Expense   200,000        
Estimated fair value of the liability   0 0      
Omniome, Inc [Member]            
Balance Sheet Components [Line Items]            
Long-term restricted cash $ 1,600,000          
Short term debt acquired 1,300,000          
Long-term debt acquired $ 3,000,000.0          
Debt Instrument, Term 43 months          
Debt Instrument Interest Rate Stated Percentage 17.00%          
Omniome, Inc [Member] | In-process research and development indefinite lived [Member]            
Balance Sheet Components [Line Items]            
Indefinite-lived Intangible Assets (Excluding Goodwill) $ 400,000,000          
Customer Deposit [Member]            
Balance Sheet Components [Line Items]            
Short-term restricted cash     500,000      
Security Deposit [Member]            
Balance Sheet Components [Line Items]            
Short-term restricted cash   500,000 300,000      
Security Deposit [Member] | Omniome, Inc [Member]            
Balance Sheet Components [Line Items]            
Short-term restricted cash $ 200,000          
O’Brien Lease Agreement [Member]            
Balance Sheet Components [Line Items]            
Long-term restricted cash   3,000,000.0 $ 3,500,000     $ 4,500,000
Service [Member]            
Balance Sheet Components [Line Items]            
Deferred revenue   36,000,000.0        
Deferred revenue, current   11,000,000.0        
Deferred revenue, non-current   25,000,000.0        
Prepaid expenses and other current assets   700,000        
Service contract [Member]            
Balance Sheet Components [Line Items]            
Deferred revenue, non-current   1,500,000        
Invitae Corporation [Member]            
Balance Sheet Components [Line Items]            
Deferred revenue, non-current   $ 23,500,000