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v3.22.1

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Cash flows from operating activities |  |
Net loss | $ (81,499) | $ (87,435)
Adjustments to reconcile net loss to net cash used in operating activities |  |
Loss from Continuation Advances |  | 52,000
Depreciation | 2,268 | 1,606
Amortization of intangible asets | 228 |
Amortization of right-of-use assets | 1,696 | 790
Amortization of debt discount and financing costs | 159 | 74
Stock-based compensation | 22,703 | 10,165
Amortization from investment premium | 758 | 565
Change in the estimated fair value of contingent consideration | (1,063) |
Loss on disposition of equipment | 100 |
Changes in assets and liabilities |  |
Accounts receivable | (3,611) | 3,931
Inventory | (6,275) | (2,556)
Prepaid expenses and other assets | (1,185) | (675)
Accounts payable | 6,373 | 153
Accrued expenses | (17,234) | (2,680)
Deferred revenue | 1,949 | 5,004
Operating lease liabilities | (1,884) | (1,066)
Other liabilities | (2,512) | (2,980)
Net cash used in operating activities | (79,029) | (23,104)
Cash flows from investing activities |  |
Purchase of property and equipment | (3,638) | (401)
Purchase of investments | (76,369) | (64,426)
Sales of investments |  | 4,597
Maturities of investments | 122,060 | 68,400
Net cash provided by investing activities | 42,053 | 8,170
Cash flows from financing activities |  |
Continuation Advances |  | (52,000)
Proceeds from issuance of Convertible Senior Notes, net of issuance costs |  | 895,624
Proceeds from issuance of common stock from equity plans | 5,592 | 22,343
Notes payable principal payoff | (377) |
Other |  | (246)
Net cash provided by financing activities | 5,215 | 865,721
Net increase in cash and cash equivalents and restricted cash | (31,761) | 850,787
Cash and cash equivalents and restricted cash at beginning of period | 465,817 | 85,947
Cash and cash equivalents and restricted cash at end of period | 434,056 | 936,734
Cash and cash equivalents at end of period | 428,574 | 932,398
Restricted cash at end of period | $ 5,482 | $ 4,336

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