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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities    
Net loss $ (81,499) $ (87,435)
Adjustments to reconcile net loss to net cash used in operating activities    
Loss from Continuation Advances   52,000
Depreciation 2,268 1,606
Amortization of intangible asets 228  
Amortization of right-of-use assets 1,696 790
Amortization of debt discount and financing costs 159 74
Stock-based compensation 22,703 10,165
Amortization from investment premium 758 565
Change in the estimated fair value of contingent consideration (1,063)  
Loss on disposition of equipment 100  
Changes in assets and liabilities    
Accounts receivable (3,611) 3,931
Inventory (6,275) (2,556)
Prepaid expenses and other assets (1,185) (675)
Accounts payable 6,373 153
Accrued expenses (17,234) (2,680)
Deferred revenue 1,949 5,004
Operating lease liabilities (1,884) (1,066)
Other liabilities (2,512) (2,980)
Net cash used in operating activities (79,029) (23,104)
Cash flows from investing activities    
Purchase of property and equipment (3,638) (401)
Purchase of investments (76,369) (64,426)
Sales of investments   4,597
Maturities of investments 122,060 68,400
Net cash provided by investing activities 42,053 8,170
Cash flows from financing activities    
Continuation Advances   (52,000)
Proceeds from issuance of Convertible Senior Notes, net of issuance costs   895,624
Proceeds from issuance of common stock from equity plans 5,592 22,343
Notes payable principal payoff (377)  
Other   (246)
Net cash provided by financing activities 5,215 865,721
Net increase in cash and cash equivalents and restricted cash (31,761) 850,787
Cash and cash equivalents and restricted cash at beginning of period 465,817 85,947
Cash and cash equivalents and restricted cash at end of period 434,056 936,734
Cash and cash equivalents at end of period 428,574 932,398
Restricted cash at end of period $ 5,482 $ 4,336