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Financial Instruments (Tables) | 6 Months Ended
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Jun. 30, 2022
Financial Instruments [Abstract] |
Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis |
| June 30, 2022 |  | December 31, 2021
(in thousands) | Level 1 |  | Level 2 |  | Level 3 |  | Total |  | Level 1 |  | Level 2 |  | Level 3 |  | Total
Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  | 102,612 |  |  | 207,833 |  |  | — |  |  | 310,445 |  |  | 327,315 |  |  | 133,410 |  |  | — |  |  | 460,725
Investments: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commercial paper |  | — |  |  | 120,495 |  |  | — |  |  | 120,495 |  |  | — |  |  | 187,632 |  |  | — |  |  | 187,632
Corporate debt securities |  | — |  |  | 46,810 |  |  | — |  |  | 46,810 |  |  | — |  |  | 8,968 |  |  | — |  |  | 8,968
U.S. government & agency securities |  | — |  |  | 421,401 |  |  | — |  |  | 421,401 |  |  | — |  |  | 387,075 |  |  | — |  |  | 387,075
Total investments |  | — |  |  | 588,706 |  |  | — |  |  | 588,706 |  |  | — |  |  | 583,675 |  |  | — |  |  | 583,675
Short-term restricted cash |  | 300 |  |  | — |  |  | — |  |  | 300 |  |  | 500 |  |  | — |  |  | — |  |  | 500
Long-term restricted cash |  | 2,922 |  |  | — |  |  | — |  |  | 2,922 |  |  | 4,592 |  |  | — |  |  | — |  |  | 4,592
Total assets measured at fair value | $ | 105,834 |  | $ | 796,539 |  | $ | — |  | $ | 902,373 |  | $ | 332,407 |  | $ | 717,085 |  | $ | — |  | $ | 1,049,492
Liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration | $ | — |  | $ | — |  | $ | 163,216 |  | $ | 163,216 |  | $ | — |  | $ | — |  | $ | 169,717 |  | $ | 169,717
Total liabilities measured at fair value | $ | — |  | $ | — |  | $ | 163,216 |  | $ | 163,216 |  | $ | — |  | $ | — |  | $ | 169,717 |  | $ | 169,717
Changes in the estimated fair value of contingent consideration liabilities [Table Text Block] |
(in thousands) |  | Level 3
Beginning balance as of December 31, 2021 | $ | 169,717
Change in estimated fair value |  | (6,501)
Ending balance as of June 30, 2022 | $ | 163,216
Summary of Cash, Cash Equivalents and Investments |
| As of June 30, 2022
|  |  | Gross |  | Gross |  |
| Amortized |  | unrealized |  | unrealized |  | Fair
(in thousands) | Cost |  | gains |  | losses |  | Value
Cash and cash equivalents |  | 310,508 |  |  | 8 |  |  | (71) |  |  | 310,445
Investments: |  |  |  |  |  |  |  |  |  |  |
Commercial paper |  | 120,899 |  |  | — |  |  | (404) |  |  | 120,495
Corporate debt securities |  | 47,083 |  |  | — |  |  | (273) |  |  | 46,810
U.S. government & agency securities |  | 426,118 |  |  | 70 |  |  | (4,787) |  |  | 421,401
Total investments |  | 594,100 |  |  | 70 |  |  | (5,464) |  |  | 588,706
Total cash, cash equivalents and investments | $ | 904,608 |  | $ | 78 |  | $ | (5,535) |  | $ | 899,151
Short-term restricted cash | $ | 300 |  | $ | — |  | $ | — |  | $ | 300
Long-term restricted cash | $ | 2,922 |  | $ | — |  | $ | — |  | $ | 2,922
| As of December 31, 2021
|  |  | Gross |  | Gross |  |
| Amortized |  | unrealized |  | unrealized |  | Fair
(in thousands) | Cost |  | gains |  | losses |  | Value
Cash and cash equivalents |  | 460,731 |  |  | — |  |  | (5) |  |  | 460,725
Investments: |  |  |  |  |  |  |  |  |  |  |
Commercial paper |  | 187,705 |  |  | — |  |  | (73) |  |  | 187,632
Corporate debt securities |  | 8,964 |  |  | 9 |  |  | (5) |  |  | 8,968
U.S. government & agency securities |  | 388,088 |  |  | 1 |  |  | (1,014) |  |  | 387,075
Total investments |  | 584,757 |  |  | 10 |  |  | (1,092) |  |  | 583,675
Total cash, cash equivalents and investments | $ | 1,045,488 |  | $ | 10 |  | $ | (1,097) |  | $ | 1,044,400
Short-term restricted cash | $ | 500 |  | $ | — |  | $ | — |  | $ | 500
Long-term restricted cash | $ | 4,592 |  | $ | — |  | $ | — |  | $ | 4,592
Summary of Contractual Maturities of Cash Equivalents and Available-for-Sale Investments |
(in thousands) | Fair Value
Due in one year or less | $ | 687,193
Due after one year through five years |  | 109,346
Total investments | $ | 796,539

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