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Financial Instruments (Tables)

9 Months Ended

Sep. 30, 2022

Financial Instruments [Abstract]

Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis

	September 30, 2022												December 31, 2021
	Level 1			Level 2			Level 3			Total			Level 1			Level 2			Level 3			Total
Assets
Cash and cash equivalents	$	63,154		$	241,279		$	—		$	304,433		$	327,315		$	133,410		$	—		$	460,725
Investments:
Commercial paper		—			57,408			—			57,408			—			187,632			—			187,632
Corporate debt securities		—			49,478			—			49,478			—			8,968			—			8,968
U.S. government & agency securities		—			423,021			—			423,021			—			387,075			—			387,075
Total investments		—			529,907			—			529,907			—			583,675			—			583,675
Short-term restricted cash		300			—			—			300			500			—			—			500
Long-term restricted cash		2,922			—			—			2,922			4,592			—			—			4,592
Total assets measured at fair value	$	66,376		$	771,186		$	—		$	837,562		$	332,407		$	717,085		$	—		$	1,049,492
Liabilities
Contingent consideration	$	—		$	—		$	167,496		$	167,496		$	—		$	—		$	169,717		$	169,717
Total liabilities measured at fair value	$	—		$	—		$	167,496		$	167,496		$	—		$	—		$	169,717		$	169,717

Changes in the estimated fair value of contingent consideration liabilities

		Level 3
Beginning balance as of December 31, 2021	$	169,717
Change in estimated fair value		(2,221)
Ending balance as of September 30, 2022	$	167,496

Summary of Cash, Cash Equivalents and Investments

	As of September 30, 2022
				Gross			Gross
	Amortized			unrealized			unrealized			Fair
	Cost			gains			losses			Value
Cash and cash equivalents		304,480			—			(47)			304,433
Investments:
Commercial paper		57,713			—			(305)			57,408
Corporate debt securities		50,098			2			(622)			49,478
U.S. government & agency securities		428,309			—			(5,288)			423,021
Total investments		536,120			2			(6,215)			529,907
Total cash, cash equivalents and investments	$	840,600		$	2		$	(6,262)		$	834,340
Short-term restricted cash	$	300		$	—		$	—		$	300
Long-term restricted cash	$	2,922		$	—		$	—		$	2,922
	As of December 31, 2021
				Gross			Gross
	Amortized			unrealized			unrealized			Fair
	Cost			gains			losses			Value
Cash and cash equivalents		460,731			—			(5)			460,725
Investments:
Commercial paper		187,705			—			(73)			187,632
Corporate debt securities		8,964			9			(5)			8,968
U.S. government & agency securities		388,088			1			(1,014)			387,075
Total investments		584,757			10			(1,092)			583,675
Total cash, cash equivalents and investments	$	1,045,488		$	10		$	(1,097)		$	1,044,400
Short-term restricted cash	$	500		$	—		$	—		$	500
Long-term restricted cash	$	4,592		$	—		$	—		$	4,592

Summary of Contractual Maturities of Cash Equivalents and Available-for-Sale Investments

	Fair Value
Due in one year or less	$	670,316
Due after one year through five years		100,870
Total investments	$	771,186

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