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Business Acquisitions (Narrative) (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 20, 2021
Jul. 20, 2021
Sep. 30, 2021
Sep. 30, 2021
Dec. 31, 2021
Sep. 30, 2022
Business Acquisition [Line Items]            
Fair value of contingent consideration         $ 169,717 $ 167,496
Issuance of common stock in Private Placement, net of issuance costs     $ 294,845 $ 294,845    
Acquisition-related costs     30,726 30,726    
Goodwill         409,974 409,974
Finite-Lived Intangible Assets, Gross         11,360 11,360
Income Tax Expense (Benefit)     (94,824) (94,824)    
Circulomics, Inc [Member]            
Business Acquisition [Line Items]            
Total cash paid   $ 29,500        
Goodwill   19,309        
Finite-Lived Intangible Assets, Gross   $ 11,400        
Omniome, Inc [Member]            
Business Acquisition [Line Items]            
Total cash paid $ 315,703          
Fair value of share consideration 249,435          
Fair value of contingent consideration 168,574          
Contingent Consideration Incurred during period $ 168,600          
Issuance of common stock 8,911,580          
Consideration $ 714,789          
Acquisition-related costs 11,600   11,600 11,600    
Stock-based compensation expense 18,900          
Income tax benefit from reduction in deferred tax assets valuation allowance 92,200          
Pro forma adjustment related to acquiree's acquisition-related costs 16,700          
Since the date of acquisition, revenues     $ 0 0    
Since the date of acquisition, net loss       $ 1,600    
Goodwill 390,665          
Omniome, Inc [Member] | Effect of Change Higher/(Lower) [Member]            
Business Acquisition [Line Items]            
Goodwill         (1,600)  
Deferred Tax Liabilities, Deferred Expense         (400)  
Income Tax Expense (Benefit)         (1,200)  
Omniome, Inc [Member] | Omniome stock awards related to acquisition [Member]            
Business Acquisition [Line Items]            
Total cash paid 7,400          
Fair value of share consideration 6,300          
Contingent Consideration Incurred during period $ 5,200          
Issuance of common stock 226,811          
Consideration $ 18,900          
Achievement of milestone [Member] | Omniome, Inc [Member]            
Business Acquisition [Line Items]            
Total cash paid 100,000          
Fair value of share consideration 100,000          
Fair value of contingent consideration 200,000          
Stock options issued by PacBio in replacement of Omniome’s unvested options $ 4,100          
Percentage of outstanding shares of common to be issued in merger 19.90%          
Issuance of common stock in Private Placement, net of issuance costs shares 11,500,000          
Developed Technology [Member]            
Business Acquisition [Line Items]            
Finite-Lived Intangible Assets, Gross         $ 11,000 $ 11,000