<SEC-DOCUMENT>0001299130-22-000022.txt : 20220217
<SEC-HEADER>0001299130-22-000022.hdr.sgml : 20220217
<ACCEPTANCE-DATETIME>20220217201142
ACCESSION NUMBER:		0001299130-22-000022
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220216
FILED AS OF DATE:		20220217
DATE AS OF CHANGE:		20220217

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ORDONEZ KATHY
		CENTRAL INDEX KEY:			0001222643

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34899
		FILM NUMBER:		22650458

	MAIL ADDRESS:	
		STREET 1:		3 GIRALDA FARMS
		STREET 2:		C/O QUEST DIAGNOSTICS
		CITY:			MADISON
		STATE:			NJ
		ZIP:			07940

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>certent-form4.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-02-16</periodOfReport>

    <issuer>
        <issuerCik>0001299130</issuerCik>
        <issuerName>PACIFIC BIOSCIENCES OF CALIFORNIA, INC.</issuerName>
        <issuerTradingSymbol>PACB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001222643</rptOwnerCik>
            <rptOwnerName>ORDONEZ KATHY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>PACIFIC BIOSCIENCES OF CALIFORNIA, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1305 O'BRIEN DRIVE</rptOwnerStreet2>
            <rptOwnerCity>MENLO PARK</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94025</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-02-16</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>3280</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11.5</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>18595</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units.</footnote>
        <footnote id="F2">This sale price represents the weighted average sale price of the shares sold ranging from $11.50 to $11.505 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Michele Farmer, Attorney-in-fact</signatureName>
        <signatureDate>2022-02-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>poakathyordonez.txt
<DESCRIPTION>POWER OF ATTORNEY
<TEXT>


POWER OF ATTORNEY

The undersigned, as a Section 16 reporting person
of Pacific Biosciences of California, Inc. (the "Company"),
hereby constitutes and appoints Susan Kim, Brett Atkins,
Michele Farmer and Andrew Hoffman, and each of them,
the undersigned's true and lawful attorney-in-fact to:

1. complete and execute Forms 3, 4 and 5 and other
forms and all amendments thereto as such attorney-in-fact
shall in his or her discretion determine to be required or
advisable pursuant to Section 16 of the Securities Exchange
Act of 1934 (as amended) and the rules and regulations promulgated
thereunder, or any successor laws and regulations, as a
consequence of the undersigned's ownership, acquisition
or disposition of securities of the Company; and

2.  do all acts necessary in order to file such forms
with the U.S. Securities and Exchange Commission, any
securities exchange or national association, the
Company and such other person or agency as the
attorney-in-fact shall deem appropriate.

The undersigned hereby ratifies and confirms all
that said attorneys-in-fact and agents shall do
or cause to be done by virtue hereof. The undersigned
acknowledges that the foregoing attorneys-in-fact,
in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company
assuming, any of the undersigned's responsibilities
to comply with Section 16 of the Securities Exchange
Act of 1934 (as amended).

This Power of Attorney shall remain in full force
and effect until the undersigned is no longer required
to file Forms 3, 4 and 5 with respect to the
undersigned's holdings of and transactions in
securities issued by the Company, unless earlier
revoked by the undersigned in a signed writing
delivered to the Company and the
foregoing attorneys-in-fact.

IN WITNESS WHEREOF, the undersigned has caused
this Power of Attorney to be executed as of
February 17, 2022.


Signature: /s/ Kathy Ordonez

Name: Kathy Ordonez
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
