    <SEC-DOCUMENT>0001104659-22-046019-index.html : 20220414
    <SEC-HEADER>0001104659-22-046019.hdr.sgml : 20220414
    <ACCEPTANCE-DATETIME>20220414161219
    ACCESSION NUMBER:		0001104659-22-046019
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		11
    CONFORMED PERIOD OF REPORT:	20220525
    FILED AS OF DATE:		20220414
    DATE AS OF CHANGE:		20220414

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    		CENTRAL INDEX KEY:			0001299130
    		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
    		IRS NUMBER:				161590339
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-34899
    		FILM NUMBER:		22827381

    	BUSINESS ADDRESS:
    		STREET 1:		1305 O'BRIEN DRIVE
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025
    		BUSINESS PHONE:		650-521-8000

    	MAIL ADDRESS:
    		STREET 1:		1305 O'BRIEN DRIVE
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
    		DATE OF NAME CHANGE:	20050829

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	NANOFLUIDICS INC
    		DATE OF NAME CHANGE:	20040729
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>tm2212363-1_def14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: tm2212363-1_def14a.htm

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    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>lg_pacbio-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: lg_pacbio-4c.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>sg_christian-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: sg_christian-4c.jpg

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    <SEQUENCE>4
    <FILENAME>sg_brett-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: sg_brett-bw.jpg

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    <SEQUENCE>5
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tm2212363d1-lc_comparbwlr.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>tm2212363d1-icon_wedo4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: tm2212363d1-icon_wedo4c.jpg

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    <SEQUENCE>7
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: tm2212363d1-icon_weavoid4c.jpg

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    <SEQUENCE>8
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: tm2212363d1-icon_tick4c.jpg

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    <DOCUMENT>
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    <SEQUENCE>9
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: tm2212363d1-icon_wrong4c.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>10
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: tm2212363d1-px_01page4c.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>tm2212363d1-px_02page4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: tm2212363d1-px_02page4c.jpg

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