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Business Acquisitions (Narrative) (Details) - USD ($) |  |  | 12 Months Ended
--- | --- | --- | ---
Sep. 20, 2021 | Jul. 20, 2021 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Business Acquisition [Line Items] |  |  |  |  |
Issuance of common stock in Private Placement, net of issuance costs |  |  |  | $ 294,845,000 |
Acquisition-related costs |  |  |  | 31,129,000 |
Stock-based compensation expense |  |  | $ 78,613,000 | 80,728,000 | $ 17,533,000
Goodwill |  |  | 409,974,000 | 409,974,000 |
Finite-Lived Intangible Assets, Gross |  | $ 11,400,000 | 11,539,000 |  |
Income Tax Expense (Benefit) |  |  |  | (93,649,000) |
Circulomics, Inc [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Total cash paid |  | 29,500,000 |  |  |
Goodwill |  | $ 19,309,000 |  |  |
Omniome, Inc [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Total cash paid | $ 315,703,000 |  |  |  |
Fair value of share consideration | 249,435,000 |  |  |  |
Fair value of contingent consideration | 168,574,000 |  |  |  |
Contingent Consideration Incurred during period | $ 168,600,000 |  |  |  |
Issuance of common stock | 8,911,580 |  |  |  |
Consideration | $ 714,789,000 |  |  |  |
Acquisition-related costs | 12,000,000.0 |  |  | 12,000,000.0 |
Stock-based compensation expense | 18,900,000 |  |  |  |
Income tax benefit from reduction in deferred tax assets valuation allowance | 91,000,000.0 |  |  |  |
Pro forma adjustment related to acquiree's acquisition-related costs | 16,700,000 |  |  |  |
Since the date of acquisition, revenues |  |  |  | 0 |
Since the date of acquisition, net loss |  |  |  | 15,600,000 |
Goodwill | 390,665,000 |  | 410,000,000.0 |  |
Omniome, Inc [Member] | Effect of Change Higher/(Lower) [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Goodwill |  |  |  | (1,600,000) |
Deferred Tax Liabilities, Deferred Expense |  |  |  | (400,000) |
Income Tax Expense (Benefit) |  |  |  | $ (1,200,000) |
Omniome, Inc [Member] | Omniome stock awards related to acquisition [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Total cash paid | 7,400,000 |  |  |  |
Fair value of share consideration | 6,300,000 |  |  |  |
Contingent Consideration Incurred during period | $ 5,200,000 |  |  |  |
Issuance of common stock | 226,811 |  |  |  |
Consideration | $ 18,900,000 |  |  |  |
Achievement of milestone [Member] | Omniome, Inc [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Total cash paid | 100,000,000 |  |  |  |
Fair value of share consideration | 100,000,000 |  |  |  |
Fair value of contingent consideration | 200,000,000 |  |  |  |
Stock options issued by PacBio in replacement of Omniome’s unvested options | $ 4,100,000 |  |  |  |
Percentage of outstanding shares of common to be issued in merger | 19.90% |  |  |  |
Issuance of common stock in Private Placement, net of issuance costs | $ 11,500,000 |  |  |  |
Developed Technology [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Finite-Lived Intangible Assets, Gross |  |  | $ 11,179,000 |  |

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