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Income Taxes (Reconciliation of Deferred Tax Assets and Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 400,629 | $ 378,035
Research and development credits | 71,526 | 60,672
Capitalized research and experimental expenses | 34,863 |
Accruals and reserves | 18,417 | 10,822
Stock-based compensation | 17,117 | 12,838
ASC842 Operating lease liability | 11,537 | 13,105
Total deferred tax assets | 554,089 | 475,472
Less: Valuation allowance | (445,574) | (366,940)
Total deferred tax assets: | 108,515 | 108,532
Intangibles | (98,931) | (97,345)
Fixed assets | (1,262) | (1,523)
ASC 842 Operating Lease right-of-use assets | (9,157) | (10,502)
Total deferred tax liabilities | (109,350) | (109,370)
Net deferred tax liabilities | $ (835) | $ (838)

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