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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Income Taxes [Abstract] |
Reconciliation of Federal Income Tax Rate |
|  | Years ended December 31,
|  | 2022 |  |  | 2021 |  |  | 2020 |
Statutory tax rate |  | 21.0 | % |  | 21.0 | % |  | 21.0 | %
State tax rate, net of federal benefit |  | 4.4 |  |  | 5.5 |  |  | (8.3) |
Change in valuation allowance |  | (25.1) |  |  | (4.9) |  |  | 6.3 |
Tax credits |  | 2.2 |  |  | 2.5 |  |  | (3.6) |
Share-based compensation |  | (2.2) |  |  | 10.9 |  |  | (15.2) |
Merger Expenses |  | - |  |  | (0.9) |  |  | - |
Other |  | (0.4) |  |  | (0.1) |  |  | (0.2) |
Total |  | (0.1) | % |  | 34.0 | % |  | 0.0 | %
Reconciliation of Deferred Tax Assets and Liabilities |
|  | December 31,
|  | 2022 |  | 2021
Deferred tax assets: |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 400,629 |  | $ | 378,035
Research and development credits |  |  | 71,526 |  |  | 60,672
Capitalized research and experimental expenses |  |  | 34,863 |  |  | —
Accruals and reserves |  |  | 18,417 |  |  | 10,822
Share-based compensation |  |  | 17,117 |  |  | 12,838
Operating lease liability |  |  | 11,537 |  |  | 13,105
Total deferred tax assets |  |  | 554,089 |  |  | 475,472
Less: Valuation allowance |  |  | (445,574) |  |  | (366,940)
Total deferred tax assets: |  |  | 108,515 |  |  | 108,532
Intangibles |  |  | (98,931) |  |  | (97,345)
Fixed assets |  |  | (1,262) |  |  | (1,523)
Operating lease right-of-use assets |  |  | (9,157) |  |  | (10,502)
Total deferred tax liabilities |  |  | (109,350) |  |  | (109,370)
Net deferred tax assets |  | $ | (835) |  | $ | (838)
Reconciliation of Unrecognized Tax Benefit Accounts |
Balance as of December 31, 2019 |  | $ | 21,979
Decrease in balance related to tax positions taken in prior year |  |  | (17,255)
Increase in balance related to tax positions taken during current year |  |  | 1,230
Balance as of December 31, 2020 |  |  | 5,954
Increase in balance related to tax positions taken in prior year |  |  | 189
Increase in balance related to tax positions taken during current year |  |  | 2,192
Balance as of December 31, 2021 |  |  | 8,335
Decrease in balance related to tax positions taken in prior year |  |  | (10)
Increase in balance related to tax positions taken during current year |  |  | 2,085
Balance as of December 31, 2022 |  | $ | 10,410

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