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Document And Entity Information - USD ($)
 12 Months Ended
Dec. 31, 2022
Jan. 31, 2023
Jun. 30, 2022
Document And Entity Information [Abstract]      
Document Type 10-K    
Document Annual Report true    
Current Fiscal Year End Date --12-31    
Document Period End Date Dec. 31, 2022    
Document Fiscal Year Focus 2022    
Document Transition Report false    
Entity File Number 001-34899    
Entity Registrant Name Pacific Biosciences of California, Inc.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 16-1590339    
Entity Address, Address Line One 1305 O’Brien Drive    
Entity Address, City or Town Menlo Park    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 94025    
City Area Code 650    
Local Phone Number 521-8000    
Title of 12(b) Security Common Stock, par value $0.001 per share    
Trading Symbol PACB    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer Yes    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
ICFR Auditor Attestation Flag true    
Entity Shell Company false    
Entity Public Float     $ 991,868,509
Entity Common Stock Shares Outstanding   247,079,374  
Amendment Flag false    
Entity Central Index Key 0001299130    
Document Fiscal Period Focus FY    
Documents Incorporated by Reference Portions of the registrant’s definitive Proxy Statement relating to its 2023 Annual Meeting of Stockholders are incorporated by reference into Part III of this Annual Report on Form 10-K where indicated. Such Proxy Statement will be filed with the U.S. Securities and Exchange Commission within 120 days after the end of the fiscal year to which this report relates.    
Auditor Name Ernst & Young LLP    
Auditor Location San Mateo, California    
Auditor Firm Id 42