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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Taxes [Abstract]

Reconciliation of Federal Income Tax Rate

		Years ended December 31,
		2022			2021			2020
Statutory tax rate		21.0	%		21.0	%		21.0	%
State tax rate, net of federal benefit		4.4			5.5			(8.3)
Change in valuation allowance		(25.1)			(4.9)			6.3
Tax credits		2.2			2.5			(3.6)
Share-based compensation		(2.2)			10.9			(15.2)
Merger Expenses		-			(0.9)			-
Other		(0.4)			(0.1)			(0.2)
Total		(0.1)	%		34.0	%		0.0	%

Reconciliation of Deferred Tax Assets and Liabilities

		December 31,
		2022			2021
Deferred tax assets:
Net operating loss carryforwards		$	400,629		$	378,035
Research and development credits			71,526			60,672
Capitalized research and experimental expenses			34,863			—
Accruals and reserves			18,417			10,822
Share-based compensation			17,117			12,838
Operating lease liability			11,537			13,105
Total deferred tax assets			554,089			475,472
Less: Valuation allowance			(445,574)			(366,940)
Total deferred tax assets:			108,515			108,532
Intangibles			(98,931)			(97,345)
Fixed assets			(1,262)			(1,523)
Operating lease right-of-use assets			(9,157)			(10,502)
Total deferred tax liabilities			(109,350)			(109,370)
Net deferred tax assets		$	(835)		$	(838)

Reconciliation of Unrecognized Tax Benefit Accounts

Balance as of December 31, 2019		$	21,979
Decrease in balance related to tax positions taken in prior year			(17,255)
Increase in balance related to tax positions taken during current year			1,230
Balance as of December 31, 2020			5,954
Increase in balance related to tax positions taken in prior year			189
Increase in balance related to tax positions taken during current year			2,192
Balance as of December 31, 2021			8,335
Decrease in balance related to tax positions taken in prior year			(10)
Increase in balance related to tax positions taken during current year			2,085
Balance as of December 31, 2022		$	10,410

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of the change in unrecognized tax benefits.

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