    <SEC-DOCUMENT>0001104659-23-045019-index.html : 20230413
    <SEC-HEADER>0001104659-23-045019.hdr.sgml : 20230413
    <ACCEPTANCE-DATETIME>20230413160722
    ACCESSION NUMBER:		0001104659-23-045019
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230413
    DATE AS OF CHANGE:		20230413
    EFFECTIVENESS DATE:		20230413

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    		CENTRAL INDEX KEY:			0001299130
    		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
    		IRS NUMBER:				161590339
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-34899
    		FILM NUMBER:		23818445

    	BUSINESS ADDRESS:
    		STREET 1:		1305 O'BRIEN DRIVE
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025
    		BUSINESS PHONE:		650-521-8000

    	MAIL ADDRESS:
    		STREET 1:		1305 O'BRIEN DRIVE
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
    		DATE OF NAME CHANGE:	20050829

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	NANOFLUIDICS INC
    		DATE OF NAME CHANGE:	20040729
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>tm2312110d1_ars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: tm2312110d1_ars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>