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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities    
Net loss $ (88,015) $ (81,499)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation 2,755 2,268
Amortization of intangible assets 234 228
Amortization of right-of-use assets 1,527 1,696
Amortization of debt discount and financing costs 162 159
Share-based compensation expense 17,952 22,703
Accretion of discount and amortization of premium on marketable securities, net (2,155) 758
Change in the estimated fair value of contingent consideration 12,256 (1,063)
Inventory provision 3,521 386
Loss on disposition of equipment 201 100
Changes in assets and liabilities    
Accounts receivable, net (10,803) (3,611)
Inventory, net (13,319) (6,661)
Prepaid expenses and other assets (6,888) (1,185)
Accounts payable 5,068 6,373
Accrued expenses (13,186) (17,234)
Deferred revenue 423 1,949
Operating lease liabilities (1,969) (1,884)
Other liabilities (2,455) (2,512)
Net cash used in operating activities (94,691) (79,029)
Cash flows from investing activities    
Purchase of property and equipment (3,721) (3,638)
Purchase of investments (233,291) (76,369)
Sales of investments 595 0
Maturities of investments 163,864 122,060
Net cash (used in) provided by investing activities (72,553) 42,053
Cash flows from financing activities    
Proceeds from issuance of common stock under equity offerings, net of issuance costs 189,200 0
Proceeds from issuance of common stock from equity plans 7,235 5,592
Notes payable principal payoff (446) (377)
Net cash provided by financing activities 195,989 5,215
Net increase (decrease) in cash, cash equivalents, and restricted cash 28,745 (31,761)
Cash and cash equivalents and restricted cash at beginning of period 328,311 465,817
Cash and cash equivalents and restricted cash at end of period 357,056 434,056
Cash and cash equivalents at end of period 353,834 428,574
Restricted cash at end of period 3,222 5,482
Cash, cash equivalents, and restricted cash at end of period $ 357,056 $ 434,056