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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Cash flows from operating activities    
Net loss $ (157,848) $ (152,893)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation 5,584 4,591
Amortization of intangible assets 466 456
Amortization of right-of-use assets 3,330 3,412
Amortization of debt discount and financing costs 324 319
Share-based compensation expense 35,843 41,722
Accretion of discount and amortization of premium on marketable securities, net (6,113) 1,143
Change in the estimated fair value of contingent consideration 14,231 (6,501)
Loss on extinguishment of debt 2,033 0
Inventory provision 4,295 1,789
Loss on disposition of equipment 45 77
Changes in assets and liabilities    
Accounts receivable, net (5,248) (2,817)
Inventory (19,703) (14,955)
Prepaid expenses and other assets (6,085) (340)
Accounts payable 4,262 1,331
Accrued expenses (5,956) (11,357)
Deferred revenue (2,317) (2,115)
Operating lease liabilities (4,114) (3,833)
Other liabilities 539 379
Net cash used in operating activities (136,432) (139,592)
Cash flows from investing activities    
Purchase of property and equipment (5,989) (7,657)
Purchases of investments (476,879) (241,086)
Sales of investments 595 0
Maturities of investments 311,129 230,515
Net cash used in investing activities (171,144) (18,228)
Cash flows from financing activities    
Proceeds from issuance of common stock under equity offerings, net of issuance costs 189,200 0
Proceeds from issuance of common stock from equity plans 9,821 6,440
Payment of debt issuance costs (6,836) 0
Notes payable principal payoff (911) (770)
Net cash provided by financing activities 191,274 5,670
Net decrease in cash, cash equivalents, and restricted cash (116,302) (152,150)
Cash, cash equivalents, and restricted cash at beginning of period 328,311 465,817
Cash, cash equivalents, and restricted cash at end of period 212,009 313,667
Cash and cash equivalents at end of period 209,287 310,445
Restricted cash at end of period 2,722 3,222
Cash, cash equivalents, and restricted cash at end of period $ 212,009 $ 313,667