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Condensed Consolidated Statements of Stockholders’ Equity (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021   220,978      
Beginning balance at Dec. 31, 2021 $ 790,987 $ 221 $ 2,009,945 $ (1,087) $ (1,218,092)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (229,864)       (229,864)
Other comprehensive income (loss) (5,173)     (5,173)  
Issuance of common stock in conjunction with equity plans (in shares)   4,938      
Issuance of common stock in conjunction with equity plans 9,983 $ 5 9,978    
Share-based compensation expense 60,658   60,658    
Ending balance (in shares) at Sep. 30, 2022   225,916      
Ending balance at Sep. 30, 2022 626,591 $ 226 2,080,581 (6,260) (1,447,956)
Beginning balance (in shares) at Jun. 30, 2022   224,756      
Beginning balance at Jun. 30, 2022 681,886 $ 225 2,058,103 (5,457) (1,370,985)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (76,971)       (76,971)
Other comprehensive income (loss) (803)     (803)  
Issuance of common stock in conjunction with equity plans (in shares)   1,160      
Issuance of common stock in conjunction with equity plans 3,543 $ 1 3,542    
Share-based compensation expense 18,936   18,936    
Ending balance (in shares) at Sep. 30, 2022   225,916      
Ending balance at Sep. 30, 2022 $ 626,591 $ 226 2,080,581 (6,260) (1,447,956)
Beginning balance (in shares) at Dec. 31, 2022 226,505 226,505      
Beginning balance at Dec. 31, 2022 $ 562,904 $ 227 2,099,782 (4,765) (1,532,340)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (224,717)       (224,717)
Other comprehensive income (loss) 2,925     2,925  
Shares issuable following milestone achievement 84,761   84,761    
Issuance of common stock in acquisition of Apton (in shares)   6,121      
Issuance of common stock in acquisition of Apton 76,642 $ 6 76,636    
Issuance of common stock in connection with liquidity event bonus plan (in shares)   169      
Issuance of common stock in connection with liquidity event bonus plan 2,111   2,111    
Issuance of common stock from Underwritten Public Equity Offering, net of issuance costs (in shares)   20,125      
Issuance of common stock from Underwritten Public Equity Offering, net of issuance costs 189,200 $ 20 189,180    
Issuance of common stock in conjunction with equity plans (in shares)   5,454      
Issuance of common stock in conjunction with equity plans 14,383 $ 5 14,378    
Share-based compensation expense $ 55,534   55,534    
Ending balance (in shares) at Sep. 30, 2023 258,374 258,374      
Ending balance at Sep. 30, 2023 $ 763,743 $ 258 2,522,382 (1,840) (1,757,057)
Beginning balance (in shares) at Jun. 30, 2023   250,473      
Beginning balance at Jun. 30, 2023 641,999 $ 250 2,334,623 (2,686) (1,690,188)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (66,869)       (66,869)
Other comprehensive income (loss) 846     846  
Shares issuable following milestone achievement 84,761   84,761    
Issuance of common stock in acquisition of Apton (in shares)   6,121      
Issuance of common stock in acquisition of Apton 76,642 $ 6 76,636    
Issuance of common stock in connection with liquidity event bonus plan (in shares)   169      
Issuance of common stock in connection with liquidity event bonus plan 2,111   2,111    
Issuance of common stock in conjunction with equity plans (in shares)   1,611      
Issuance of common stock in conjunction with equity plans 4,562 $ 2 4,560    
Share-based compensation expense $ 19,691   19,691    
Ending balance (in shares) at Sep. 30, 2023 258,374 258,374      
Ending balance at Sep. 30, 2023 $ 763,743 $ 258 $ 2,522,382 $ (1,840) $ (1,757,057)