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Consolidated Statements of Stockholders’ Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2020   192,294,000      
Beginning balance at Dec. 31, 2020 $ 335,491 $ 192 $ 1,372,083 $ 85 $ (1,036,869)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (181,223)       (181,223)
Other comprehensive (loss) income (1,172)     (1,172)  
Issuance of common stock in conjunction with equity plans (in shares)   8,557,000      
Issuance of common stock in conjunction with equity plans 31,806 $ 9 31,797    
Issuance of common stock in Private Placement/Underwritten Public Offering, net of issuance costs (in shares)   11,215,000      
Issuance of common stock in Private Placement/Underwritten Public Offering, net of issuance costs 294,845 $ 11 294,834    
Issuance of common stock in acquisition (in shares)   8,912,000      
Issuance of common stock in acquisition 237,885 $ 9 237,876    
Share-based compensation expense 73,355   73,355    
Ending balance at Dec. 31, 2021 790,987 $ 221 2,009,945 (1,087) (1,218,092)
Ending balance (in shares) at Dec. 31, 2021   220,978,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (314,248)       (314,248)
Other comprehensive (loss) income (3,678)     (3,678)  
Issuance of common stock in conjunction with equity plans (in shares)   5,527,000      
Issuance of common stock in conjunction with equity plans 11,230 $ 6 11,224    
Share-based compensation expense 78,613   78,613    
Ending balance at Dec. 31, 2022 $ 562,904 $ 227 2,099,782 (4,765) (1,532,340)
Ending balance (in shares) at Dec. 31, 2022 226,505,000 226,505,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss $ (306,735)       (306,735)
Other comprehensive (loss) income 4,984     4,984  
Issuance of common stock in conjunction with equity plans (in shares)   5,836,000      
Issuance of common stock in conjunction with equity plans 15,319 $ 6 15,313    
Issuance of common stock in Private Placement/Underwritten Public Offering, net of issuance costs (in shares)   20,125,000      
Issuance of common stock in Private Placement/Underwritten Public Offering, net of issuance costs 189,200 $ 20 189,180    
Issuance of common stock in acquisition (in shares)   6,121,000      
Issuance of common stock in acquisition 76,642 $ 6 76,636    
Share-based compensation expense $ 72,118   72,118    
Issuance of common stock following milestone achievement (in shares) 8,988,391 8,988,000      
Issuance of common stock following milestone achievement $ 84,761 $ 9 84,752    
Issuance of common stock in connection with liquidity event bonus plan (in shares)   169,000      
Issuance of common stock in connection with Apton liquidity event bonus plan 2,111   2,111    
Ending balance at Dec. 31, 2023 $ 701,304 $ 268 $ 2,539,892 $ 219 $ (1,839,075)
Ending balance (in shares) at Dec. 31, 2023 267,744,000 267,744,000