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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities      
Net loss $ (306,735) $ (314,248) $ (181,223)
Adjustments to reconcile net loss to net cash used in operating activities      
Loss (gain) from Continuation Advances 0 0 52,000
Depreciation 11,463 9,480 7,199
Amortization of intangible assets 8,261 913 381
Amortization of right-of-use assets 6,810 6,925 4,005
Share-based compensation 72,118 78,613 73,355
Merger-related compensation expense 3,395 0 0
Loss on extinguishment of debt 2,033 0 0
Amortization of premium and accretion of discount on marketable securities, net (12,840) (244) 4,011
Change in fair value of contingent consideration 15,060 2,377 1,143
Inventory provision 10,584 6,027 678
Deferred income taxes (11,424) 0 (93,649)
Other 1,059 918 593
Changes in assets and liabilities      
Accounts receivable, net (17,829) 5,455 (7,166)
Inventory, net (13,841) (33,906) (13,109)
Prepaid expenses and other assets (8,984) (12,324) (1,024)
Accounts payable 206 1,025 6,363
Accrued expenses 13,103 (3,651) 15,320
Deferred revenue (10,420) (3,734) 25,736
Operating lease liabilities (8,759) (7,724) (4,990)
Contingent consideration liability (14,882) 0 0
Other liabilities 2,449 887 (803)
Net cash used in operating activities (259,173) (263,211) (111,180)
Cash flows from investing activities      
Purchase of property and equipment (8,843) (16,750) (5,931)
Purchase of intangible assets 0 (179) 0
Purchase of investments (756,567) (442,788) (988,046)
Sales of investments 595 0 212,734
Maturities of investments 769,521 575,800 422,505
Net cash provided by (used in) in investing activities 4,604 116,083 (678,531)
Cash flows from financing activities      
Continuation Advances 0 0 (52,000)
Proceeds from issuance of Convertible Senior Notes, net of issuance costs 0 0 895,536
Proceeds from issuance of common stock under equity offerings, net of issuance costs 189,200 0 294,845
Proceeds from issuance of common stock from equity plans 15,319 11,230 31,806
Payment of debt issuance costs (7,375) 0 0
Payment of contingent consideration (86,411) 0 0
Notes payable principal payoff (1,842) (1,608) (361)
Other 0 0 (245)
Net cash provided by financing activities 108,891 9,622 1,169,581
Net (decrease) increase in cash, cash equivalents, and restricted cash (145,678) (137,506) 379,870
Cash, cash equivalents, and restricted cash at beginning of period 328,311 465,817 85,947
Cash, cash equivalents, and restricted cash at end of period 182,633 328,311 465,817
Cash and cash equivalents at end of period 179,911 325,089 460,725
Restricted cash at end of period 2,722 3,222 5,092
Supplemental disclosure of cash flow information      
Interest paid 15,687 14,049 6,928
Supplemental disclosure of non-cash investing and financing activities      
Convertible Senior Notes exchange 441,000 0 0
Liquidity Bonus Event      
Supplemental disclosure of non-cash investing and financing activities      
Issuance of common stock 2,111 0 0
Milestone Achievement      
Supplemental disclosure of non-cash investing and financing activities      
Issuance of common stock 84,761 0 0
Circulomics, Inc      
Cash flows from investing activities      
Cash paid for purchase of business acquisition, net of cash acquired (102) 0 (319,793)
Apton And Omniome      
Supplemental disclosure of non-cash investing and financing activities      
Inventory transferred to property and equipment 3,984 2,812 2,586
Property and equipment transferred to inventory (7,022) (715) (383)
Right-of-use asset and liability additions and modifications 0 0 2,576
Apton And Omniome | Business Combination      
Supplemental disclosure of non-cash investing and financing activities      
Issuance of common stock $ 76,642 $ 0 $ 237,885