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Condensed Consolidated Statements of Stockholders’ Equity (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2022   226,505      
Beginning balance at Dec. 31, 2022 $ 562,904 $ 227 $ 2,099,782 $ (4,765) $ (1,532,340)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (224,717)       (224,717)
Other comprehensive income 2,925     2,925  
Shares issuable following milestone achievement 84,761   84,761    
Issuance of common stock in acquisition of Apton (in shares)   6,121      
Issuance of common stock in acquisition of Apton 76,642 $ 6 76,636    
Issuance of common stock in connection with liquidity event bonus plan (in shares)   169      
Issuance of common stock in connection with liquidity event bonus plan 2,111   2,111    
Issuance of common stock from Underwritten Public Equity Offering, net of issuance costs (in shares)   20,125      
Issuance of common stock from Underwritten Public Equity Offering, net of issuance costs 189,200 $ 20 189,180    
Issuance of common stock in conjunction with equity plans (in shares)   5,454      
Issuance of common stock in conjunction with equity plans 14,383 $ 5 14,378    
Share-based compensation expense 55,534   55,534    
Ending balance (in shares) at Sep. 30, 2023   258,374      
Ending balance at Sep. 30, 2023 763,743 $ 258 2,522,382 (1,840) (1,757,057)
Beginning balance (in shares) at Dec. 31, 2022   226,505      
Beginning balance at Dec. 31, 2022 $ 562,904 $ 227 2,099,782 (4,765) (1,532,340)
Ending balance (in shares) at Dec. 31, 2023 267,744 267,744      
Ending balance at Dec. 31, 2023 $ 701,304 $ 268 2,539,892 219 (1,839,075)
Beginning balance (in shares) at Jun. 30, 2023   250,473      
Beginning balance at Jun. 30, 2023 641,999 $ 250 2,334,623 (2,686) (1,690,188)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (66,869)       (66,869)
Other comprehensive income 846     846  
Shares issuable following milestone achievement 84,761   84,761    
Issuance of common stock in acquisition of Apton (in shares)   6,121      
Issuance of common stock in acquisition of Apton 76,642 $ 6 76,636    
Issuance of common stock in connection with liquidity event bonus plan (in shares)   169      
Issuance of common stock in connection with liquidity event bonus plan 2,111   2,111    
Issuance of common stock in conjunction with equity plans (in shares)   1,611      
Issuance of common stock in conjunction with equity plans 4,562 $ 2 4,560    
Share-based compensation expense 19,691   19,691    
Ending balance (in shares) at Sep. 30, 2023   258,374      
Ending balance at Sep. 30, 2023 $ 763,743 $ 258 2,522,382 (1,840) (1,757,057)
Beginning balance (in shares) at Dec. 31, 2023 267,744 267,744      
Beginning balance at Dec. 31, 2023 $ 701,304 $ 268 2,539,892 219 (1,839,075)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (312,222)       (312,222)
Other comprehensive income 1,334     1,334  
Issuance of common stock in conjunction with equity plans (in shares)   6,068      
Issuance of common stock in conjunction with equity plans 7,703 $ 6 7,697    
Share-based compensation expense $ 55,003   55,003    
Ending balance (in shares) at Sep. 30, 2024 273,812 273,812      
Ending balance at Sep. 30, 2024 $ 453,122 $ 274 2,602,592 1,553 (2,151,297)
Beginning balance (in shares) at Jun. 30, 2024   272,491      
Beginning balance at Jun. 30, 2024 492,700 $ 272 2,583,523 (523) (2,090,572)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (60,725)       (60,725)
Other comprehensive income 2,076     2,076  
Issuance of common stock in conjunction with equity plans (in shares)   1,321      
Issuance of common stock in conjunction with equity plans 812 $ 2 810    
Share-based compensation expense $ 18,259   18,259    
Ending balance (in shares) at Sep. 30, 2024 273,812 273,812      
Ending balance at Sep. 30, 2024 $ 453,122 $ 274 $ 2,602,592 $ 1,553 $ (2,151,297)