<SEC-DOCUMENT>0001299130-24-000113-index.html : 20240509
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<ACCEPTANCE-DATETIME>20240509163312
ACCESSION NUMBER:		0001299130-24-000113
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20240509
DATE AS OF CHANGE:		20240509
EFFECTIVENESS DATE:		20240509

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-279269
		FILM NUMBER:		24931307

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729
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<TYPE>S-3ASR
<SEQUENCE>1
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<DESCRIPTION>S-3ASR
<TEXT>
Document 1 - file: pacb-20240509xformsx3.htm

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<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>2
<FILENAME>pacb-20240509xex107.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 2 - file: pacb-20240509xex107.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>pacb-51_opinionxmayx2024.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 3 - file: pacb-51_opinionxmayx2024.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>pacb-20240509xex231xformsx3.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 4 - file: pacb-20240509xex231xformsx3.htm

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<SEQUENCE>5
<FILENAME>image1a.jpg
<TEXT>
Document 5 - file: image1a.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>imagea.jpg
<TEXT>
Document 6 - file: imagea.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>pacb-51_opinionxmayx2024001.jpg
<TEXT>
Document 7 - file: pacb-51_opinionxmayx2024001.jpg

</DOCUMENT>
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