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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities |  |  |
Net loss | $ (309,851) | $ (306,735) | $ (314,248)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Depreciation | 13,774 | 11,463 | 9,480
Amortization of intangible assets | 27,412 | 8,261 | 913
Amortization of right-of-use assets | 12,165 | 6,810 | 6,925
Share-based compensation expense | 71,036 | 72,118 | 78,613
Impairment charges | 184,500 | 0 | 0
Merger-related compensation expense | 0 | 3,395 | 0
Loss on extinguishment of debt | 0 | 2,033 | 0
Gain on debt restructuring | (154,407) | 0 | 0
Accretion of discount and amortization of premium on marketable securities, net | (13,044) | (12,840) | (244)
Change in the estimated fair value of contingent consideration | (850) | 15,060 | 2,377
Inventory provision | 4,618 | 10,584 | 6,027
Deferred income taxes | (205) | (11,424) | 0
Other | (628) | 1,059 | 918
Changes in assets and liabilities |  |  |
Accounts receivable, net | 9,091 | (17,829) | 5,455
Inventory, net | (8,320) | (13,841) | (33,906)
Prepaid expenses and other assets | 2,228 | (8,984) | (12,324)
Accounts payable | 1,405 | 206 | 1,025
Accrued expenses | (26,342) | 13,103 | (3,651)
Deferred revenue | (2,108) | (10,420) | (3,734)
Operating lease liabilities | (11,920) | (8,759) | (7,724)
Contingent consideration liability | 0 | (14,882) | 0
Other liabilities | (4,612) | 2,449 | 887
Net cash used in operating activities | (206,058) | (259,173) | (263,211)
Cash flows from investing activities |  |  |
Purchase of property and equipment | (6,188) | (8,843) | (16,750)
Purchase of intangible assets | 0 | 0 | (179)
Cash paid for purchases of acquired entities, net of cash acquired | 0 | (102) | 0
Purchase of investments | (498,635) | (756,567) | (442,788)
Sales of investments | 34,856 | 595 | 0
Maturities of investments | 593,971 | 769,521 | 575,800
Net cash provided by investing activities | 124,004 | 4,604 | 116,083
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock under equity offerings, net of issuance costs | 0 | 189,200 | 0
Proceeds from issuance of common stock from equity plans | 7,703 | 15,319 | 11,230
Payment of debt issuance costs | 0 | (7,375) | 0
Payment of contingent consideration | 0 | (86,411) | 0
Payments made in conjunction with convertible notes exchange | 50,200 | 0 | 0
Notes payable principal payoff | (490) | (1,842) | (1,608)
Net cash (used in) provided by financing activities | (42,987) | 108,891 | 9,622
Net decrease in cash, cash equivalents, and restricted cash | (125,041) | (145,678) | (137,506)
Cash, cash equivalents, and restricted cash at beginning of period | 182,633 | 328,311 | 465,817
Cash, cash equivalents, and restricted cash at end of period | 57,592 | 182,633 | 328,311
Cash and cash equivalents at end of period | 55,370 | 179,911 | 325,089
Restricted cash at end of period | 2,222 | 2,722 | 3,222
Cash, cash equivalents, and restricted cash at end of period | 57,592 | 182,633 | 328,311
Supplemental disclosure of cash flow information |  |  |
Interest paid | 14,805 | 15,687 | 14,049
Supplemental disclosure of non-cash investing and financing activities |  |  |
Convertible notes exchange | 0 | 441,000 | 0
Note Exchange |  |  |
Supplemental disclosure of non-cash investing and financing activities |  |  |
Issuance of common stock | 36,199 | 0 | 0
Liquidity Bonus Event |  |  |
Supplemental disclosure of non-cash investing and financing activities |  |  |
Issuance of common stock | 0 | 2,111 | 0
Milestone Achievement |  |  |
Supplemental disclosure of non-cash investing and financing activities |  |  |
Issuance of common stock | 0 | 84,761 | 0
Apton And Omniome |  |  |
Supplemental disclosure of non-cash investing and financing activities |  |  |
Inventory transferred to property and equipment | 4,194 | 3,984 | 2,812
Property and equipment transferred to inventory | (2,572) | (7,022) | (715)
Right-of-use asset and liability additions and modifications | 18,253 | 0 | 0
Apton And Omniome | Business Combination |  |  |
Supplemental disclosure of non-cash investing and financing activities |  |  |
Issuance of common stock | $ 0 | $ 76,642 | $ 0

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