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CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021   220,978,000      
Beginning balance at Dec. 31, 2021 $ 790,987 $ 221 $ 2,009,945 $ (1,087) $ (1,218,092)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Basic net loss (314,248)       (314,248)
Other comprehensive (loss) income (3,678)     (3,678)  
Issuance of common stock in conjunction with equity plans (in shares)   5,527,000      
Issuance of common stock in conjunction with equity plans 11,230 $ 6 11,224    
Share-based compensation expense 78,613   78,613    
Ending balance at Dec. 31, 2022 562,904 $ 227 2,099,782 (4,765) (1,532,340)
Ending balance (in shares) at Dec. 31, 2022   226,505,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Basic net loss (306,735)       (306,735)
Other comprehensive (loss) income $ 4,984     4,984  
Issuance of common stock following milestone achievement (in shares) 8,988,391 8,988,000      
Issuance of common stock following milestone achievement $ 84,761 $ 9 84,752    
Issuance of common stock in acquisition of Apton (in shares)   6,121,000      
Issuance of common stock in acquisition of Apton 76,642 $ 6 76,636    
Issuance of common stock in connection with Apton liquidity event bonus plan (in shares)   169,000      
Issuance of common stock in connection with Apton liquidity event bonus plan 2,111   2,111    
Issuance of common stock from Underwritten Public Equity Offering, net of issuance costs (in shares)   20,125,000      
Issuance of common stock from Underwritten Public Equity Offering, net of issuance costs 189,200 $ 20 189,180    
Issuance of common stock in conjunction with equity plans (in shares)   5,836,000      
Issuance of common stock in conjunction with equity plans 15,319 $ 6 15,313    
Share-based compensation expense 72,118   72,118    
Ending balance at Dec. 31, 2023 $ 701,304 $ 268 2,539,892 219 (1,839,075)
Ending balance (in shares) at Dec. 31, 2023 267,744,000 267,744,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Basic net loss $ (309,851)       (309,851)
Other comprehensive (loss) income 203     203  
Issuance of common stock in conjunction with equity plans (in shares)   6,222,000      
Issuance of common stock in conjunction with equity plans 7,703 $ 6 7,697    
Issuance of common stock in conjunction with convertible notes exchange (in shares)   20,452,000      
Issuance of common stock in conjunction with convertible notes exchange 36,199 $ 20 36,179    
Share-based compensation expense 71,036   71,036    
Ending balance at Dec. 31, 2024 $ 506,594 $ 294 $ 2,654,804 $ 422 $ (2,148,926)
Ending balance (in shares) at Dec. 31, 2024 294,418,000 294,418,000