<SEC-DOCUMENT>0000947871-25-000682.txt : 20250724
<SEC-HEADER>0000947871-25-000682.hdr.sgml : 20250724
<ACCEPTANCE-DATETIME>20250724135430
ACCESSION NUMBER:		0000947871-25-000682
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250724
DATE AS OF CHANGE:		20250724

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
		CENTRAL INDEX KEY:			0001299130
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				161590339
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-85738
		FILM NUMBER:		251146208

	BUSINESS ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-521-8000

	MAIL ADDRESS:	
		STREET 1:		1305 O'BRIEN DRIVE
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
		DATE OF NAME CHANGE:	20050829

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NANOFLUIDICS INC
		DATE OF NAME CHANGE:	20040729

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE)
		CENTRAL INDEX KEY:			0001649592
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			I0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		47, RUE DU FAUBOURG SAINT HONORE
		CITY:			PARIS
		STATE:			I0
		ZIP:			75407
		BUSINESS PHONE:		33140172525

	MAIL ADDRESS:	
		STREET 1:		47, RUE DU FAUBOURG SAINT HONORE
		CITY:			PARIS
		STATE:			I0
		ZIP:			75407
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0000947871-24-000906</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE) -->
          <cik>0001649592</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001299130</issuerCik>
        <issuerName>Pacific Biosciences of California, Inc.</issuerName>
        <issuerCusip>69404D108</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>1305 O'Brien Drive</com:street1>
          <com:city>Menlo Park</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94025</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE)</reportingPersonName>
      <citizenshipOrOrganization>I0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>12081800.00</sharedVotingPower>
        <soleDispositivePower>1284400.00</soleDispositivePower>
        <sharedDispositivePower>12081800.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>13366200.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.5</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>EDMOND DE ROTHSCHILD ASSET MANAGEMENT (LUXEMBOURG)</reportingPersonName>
      <citizenshipOrOrganization>N4</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>12081800.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>12081800.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>12081800.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.0</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>EDMOND DE ROTHSCHILD FUND</reportingPersonName>
      <citizenshipOrOrganization>N4</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>12081800.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>12081800.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>12081800.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>4.0</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Pacific Biosciences of California, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>1305 O'Brien Drive, Menlo Park, California 94025</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This Schedule 13G is being filed on behalf of each of the following persons (each, a "Reporting Person") :
1. EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE) ("EDRAM France")

2. EDMOND DE ROTHSCHILD ASSET MANAGEMENT (LUXEMBOURG) ("EDRAM Luxembourg")

3. Edmond de Rothschild Fund ("EdR Fund")</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address of EDRAM France is 47, RUE DU FAUBOURG SAINT HONORE PARIS, France 75008.

The address of EDRAM Luxembourg is 4, RUE ROBERT STUMPER, Luxembourg L-2557.

The address of EdR Fund is 4, Rue Robert Stumper, Luxembourg L-2557.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>EDRAM France is a French entity
EDRAM Luxembourg is a Luxembourg entity
EdR Fund is a societe d'investissement a capital variable (SICAV) Luxembourg formed under the laws of Luxembourg.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>FI</typeOfPersonFiling>
        <otherTypeOfPersonFiling>investment manager</otherTypeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Ownership as of June 30, 2025 is incorporated by reference to items (5) - (9) and (11) of the cover page of each Reporting Person. Both EDRAM France and EDRAM Luxembourg, management companies, may be deemed to have beneficial ownership of the securities which are the subject of this filing through the investment and/or voting discretion it exercises over its portfolios managed.</amountBeneficiallyOwned>
        <classPercent>See the response(s) to Item 11 on the attached cover page(s).</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>See the response(s) to Item 5 on the attached cover page(s).</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>See the response(s) to Item 6 on the attached cover page(s).</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>See the response(s) to Item 7 on the attached cover page(s).</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>See the response(s) to Item 8 on the attached cover page(s).</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

By signing below I certify that, to the best of my knowledge and belief, the foreign regulatory scheme applicable to an investment manager is substantially comparable to the regulatory scheme applicable to the functionally equivalent U.S. institution(s). I also undertake to furnish to the Commission staff, upon request, information that would otherwise be disclosed in a Schedule 13D.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE)</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Benjamin Melman</signature>
        <title>Benjamin Melman / Global Chief Investment Officer</title>
        <date>07/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>EDMOND DE ROTHSCHILD ASSET MANAGEMENT (LUXEMBOURG)</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Marc Fohr</signature>
        <title>Marc Fohr / COMEX Member</title>
        <date>07/24/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Emmanuel Vergeynst</signature>
        <title>Emmanuel Vergeynst / COMEX Member</title>
        <date>07/24/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>EDMOND DE ROTHSCHILD FUND</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Flavien Duval</signature>
        <title>Flavien Duval / Member of the Board</title>
        <date>07/24/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Herve Touchais</signature>
        <title>Herve Touchais / Member of the Board</title>
        <date>07/24/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
