    <SEC-DOCUMENT>0001299130-25-000105-index.html : 20250520
    <SEC-HEADER>0001299130-25-000105.hdr.sgml : 20250520
    <ACCEPTANCE-DATETIME>20250520172651
    ACCESSION NUMBER:		0001299130-25-000105
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		17
    FILED AS OF DATE:		20250520
    DATE AS OF CHANGE:		20250520

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    		CENTRAL INDEX KEY:			0001299130
    		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
    		ORGANIZATION NAME:           	08 Industrial Applications and Services
    		EIN:				161590339
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-34899
    		FILM NUMBER:		25970107

    	BUSINESS ADDRESS:
    		STREET 1:		1305 O'BRIEN DRIVE
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025
    		BUSINESS PHONE:		650-521-8000

    	MAIL ADDRESS:
    		STREET 1:		1305 O'BRIEN DRIVE
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PACIFIC BIOSCIENCES OF CALIFORNIA INC
    		DATE OF NAME CHANGE:	20050829

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	NANOFLUIDICS INC
    		DATE OF NAME CHANGE:	20040729
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>a2025defa14a-additionalmat.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: a2025defa14a-additionalmat.htm

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    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>final2024_annualxsharehold.jpg
    <TEXT>
    Document 2 - file: final2024_annualxsharehold.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>final2024_annualxshareholda.jpg
    <TEXT>
    Document 3 - file: final2024_annualxshareholda.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>final2024_annualxshareholdb.jpg
    <TEXT>
    Document 4 - file: final2024_annualxshareholdb.jpg

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    <SEQUENCE>5
    <FILENAME>final2024_annualxshareholdc.jpg
    <TEXT>
    Document 5 - file: final2024_annualxshareholdc.jpg

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    <SEQUENCE>6
    <FILENAME>final2024_annualxshareholdd.jpg
    <TEXT>
    Document 6 - file: final2024_annualxshareholdd.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>final2024_annualxshareholde.jpg
    <TEXT>
    Document 7 - file: final2024_annualxshareholde.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>final2024_annualxshareholdf.jpg
    <TEXT>
    Document 8 - file: final2024_annualxshareholdf.jpg

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    <SEQUENCE>9
    <FILENAME>final2024_annualxshareholdg.jpg
    <TEXT>
    Document 9 - file: final2024_annualxshareholdg.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>final2024_annualxshareholdh.jpg
    <TEXT>
    Document 10 - file: final2024_annualxshareholdh.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>final2024_annualxshareholdi.jpg
    <TEXT>
    Document 11 - file: final2024_annualxshareholdi.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>final2024_annualxshareholdj.jpg
    <TEXT>
    Document 12 - file: final2024_annualxshareholdj.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>final2024_annualxshareholdk.jpg
    <TEXT>
    Document 13 - file: final2024_annualxshareholdk.jpg

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    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>final2024_annualxshareholdl.jpg
    <TEXT>
    Document 14 - file: final2024_annualxshareholdl.jpg

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    <SEQUENCE>15
    <FILENAME>final2024_annualxshareholdm.jpg
    <TEXT>
    Document 15 - file: final2024_annualxshareholdm.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>final2024_annualxshareholdn.jpg
    <TEXT>
    Document 16 - file: final2024_annualxshareholdn.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>final2024_annualxshareholdo.jpg
    <TEXT>
    Document 17 - file: final2024_annualxshareholdo.jpg

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    </SEC-DOCUMENT>