<SEC-DOCUMENT>0000914851-20-000366.txt : 20201123
<SEC-HEADER>0000914851-20-000366.hdr.sgml : 20201123
<ACCEPTANCE-DATETIME>20201123095235
ACCESSION NUMBER:		0000914851-20-000366
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20201119
FILED AS OF DATE:		20201123
DATE AS OF CHANGE:		20201123

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CRONIN DANIEL P
		CENTRAL INDEX KEY:			0001240480

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	811-07920
		FILM NUMBER:		201334587

	BUSINESS ADDRESS:	
		STREET 1:		PFIZER INC
		STREET 2:		235 EAST 42ND ST
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	MAIL ADDRESS:	
		STREET 1:		235 EAST 42ND ST
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			WESTERN ASSET HIGH INCOME OPPORTUNITY FUND INC.
		CENTRAL INDEX KEY:			0000910068
		IRS NUMBER:				133735236
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			0930

	BUSINESS ADDRESS:	
		STREET 1:		620 EIGHTH AVENUE
		STREET 2:		49TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
		BUSINESS PHONE:		888-777-0102

	MAIL ADDRESS:	
		STREET 1:		620 EIGHTH AVENUE
		STREET 2:		49TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HIGH INCOME OPPORTUNITY FUND INC
		DATE OF NAME CHANGE:	19941230

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SMITH BARNEY HIGH INCOME OPPORTUNITY FUND INC
		DATE OF NAME CHANGE:	19930913

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SMITH BARNEY HIGH INCOME FUND INC
		DATE OF NAME CHANGE:	19930802
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wf-form4_160614314198772.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-11-19</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000910068</issuerCik>
        <issuerName>WESTERN ASSET HIGH INCOME OPPORTUNITY FUND INC.</issuerName>
        <issuerTradingSymbol>HIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001240480</rptOwnerCik>
            <rptOwnerName>CRONIN DANIEL P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>620 EIGHTH AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>49TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10018</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-11-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3232</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5.37</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2949</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Includes shares acquired through the Fund's Dividend Reinvestment Plan.</footnote>
        <footnote id="F2">Includes shares acquired from mergers.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ George P. Hoyt by Power of Attorney for Daniel P. Cronin</signatureName>
        <signatureDate>2020-11-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>poaboardnov2020.htm
<DESCRIPTION>POA BOARD CEF NOV 2020
<TEXT>
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<pre>
POWER OF ATTORNEY
KNOW ALL PEOPLE BY THESE PRESENTS, that each person whose signature appears below hereby makes, constitutes and appoints each of Jane E. Trust, Christopher Berarducci, George P. Hoyt and Tara Gormel with full power to act without the other, as his or her agent and attorney-in-fact for the purpose of executing in his or her name, in his or her capacity as a trustee/director of any registered closed-end fund to which Legg Mason Partners Fund Advisor, LLC is an investment adviser, any statement of beneficial ownership on Form 3, 4 or 5 to be filed with the United States Securities and Exchange Commission.

All past acts of an attorney-in-fact in furtherance of the foregoing are hereby ratified and confirmed.

This Power of Attorney may be executed in multiple counterparts, each of which shall be deemed an original, but which taken together shall constitute one instrument.

This Power of Attorney shall be valid from the date hereof until revoked by me.

IN WITNESS WHEREOF, I have executed this instrument as of the 10th day of November, 2020.

/s/ Jane E. Trust
Jane E. Trust Trustee/Director, Chief Executive Officer and President

/s/ Robert D. Agdern
Robert D. Agdern Trustee/Director

/s/ Carol L. Colman
Carol L. Colman Trustee/Director

/s/ Daniel P. Cronin
Daniel P. Cronin Trustee/Director

/s/ Paolo M. Cucchi
Paolo M. Cucchi Trustee/Director

/s/ William R. Hutchinson
William R. Hutchinson Trustee/Director

/s/ Eileen A. Kamerick
Eileen A. Kamerick Trustee/Director

/s/ Nisha Kumar
Nisha Kumar Trustee/Director


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</SEC-DOCUMENT>
