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Share-Based Awards, Share Option Valuation (Details) - Stock Options [Member] - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
 [1]
Stock Option Activity [Roll Forward]      
Outstanding at beginning of period (in shares) [1] 6,959,347    
Granted (in shares) 1,190,378    
Forfeited (in shares) (38,156)    
Outstanding at end of period (in shares) 8,635,089   6,959,347
Options vested and exercisable at end of period (in shares) 6,357,746    
Weighted Average Exercise Price [Abstract]      
Outstanding at beginning of period (in dollars per share) [1] $ 1.06    
Granted (in dollars per share) 17.53    
forfeited (in dollars per share) 1.37    
Outstanding at end of period (in dollars per share) 3.58   $ 1.06
Options vested and exercisable at end of period (in dollars per share) $ 1.16    
Weighted-Average Remaining Contractual Term [Abstract]      
Outstanding 8 years 2 months 5 days   8 years 2 months 1 day
Granted 9 years 11 months 12 days    
Options vested and exercisable 7 years 1 month 6 days    
Aggregate Intrinsic Value [Abstract]      
Outstanding $ 130,983   $ 27,175
Options vested and exercisable $ 111,852    
Inotek [Member]      
Stock Option Activity [Roll Forward]      
Assumed as part of merger (in shares) 523,520    
Weighted Average Exercise Price [Abstract]      
Assumed as part of merger (in dollars per share) $ 2.31    
Weighted-Average Remaining Contractual Term [Abstract]      
Assumed as part of merger 7 years 6 months 11 days    
Employees and Directors [Member]      
Weighted-Average Assumptions [Abstract]      
Risk-free interest rate 2.57% 2.03%  
Expected term 5 years 9 months 4 days 5 years 10 months 10 days  
Expected volatility 88.60% 94.30%  
Expected dividend yield 0.00% 0.00%  
Exercise price $ 17.52 $ 1.21  
Fair value of common stock $ 17.52 $ 1.21  
Non-Employees [Member]      
Weighted-Average Assumptions [Abstract]      
Risk-free interest rate 2.74%    
Expected term 10 years    
Expected volatility 83.79%    
Expected dividend yield 0.00%    
Exercise price $ 18.75    
Fair value of common stock $ 18.75    
[1] Effected by Exchange Ratio