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Risks and Liquidity (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Feb. 28, 2022
Risks and Liquidity [Abstract]        
Accumulated deficit $ (772,110)   $ (713,775)  
Cash, cash equivalents and investments $ 360,000      
Shareholders' Equity Disclosure [Abstract]        
Common stock, par value (in dollars per share) $ 0.01   $ 0.01  
Issuance of common stock, net of issuance costs $ 17,222 $ 0    
At-the-Market Offering [Member]        
Shareholders' Equity Disclosure [Abstract]        
Common stock shares issued and sold (in shares) 0.9      
Issuance of common stock, net of issuance costs $ 17,200      
At-the-Market Offering [Member] | Cowen and Company, LLC [Member]        
Shareholders' Equity Disclosure [Abstract]        
Common stock, par value (in dollars per share)       $ 0.01
Common stock shares issued and sold (in shares) 4.2      
Issuance of common stock, net of issuance costs $ 63,800      
At-the-Market Offering [Member] | Cowen and Company, LLC [Member] | Maximum [Member]        
Shareholders' Equity Disclosure [Abstract]        
Aggregate offering price       $ 200,000